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Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts.

Fang R, Qiao S, Liu Y, Meng Q, Chen X, Song B, Hou X, Tian W - Int J Nanomedicine (2015)

Bottom Line: Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation.However, their delivery for sustained release in MI-affected areas has proved to be challenging.Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization.

View Article: PubMed Central - PubMed

Affiliation: Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, People's Republic of China ; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada.

ABSTRACT
Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation. However, their delivery for sustained release in MI-affected areas has proved to be challenging. In the current research, we present a study on the sustained co-delivery of BIO and IGF-1 in a hybrid hydrogel system to simulate endogenous cardiac repair in an MI rat model. Both BIO and IGF-1 were efficiently encapsulated in gelatin nanoparticles, which were later cross-linked with the oxidized alginate to form a novel hybrid hydrogel system. The in vivo results indicated that the hybrid system could enhance the proliferation of cardiomyocytes in situ and could promote revascularization around the MI sites, allowing improved cardiac function. Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization.

No MeSH data available.


Related in: MedlinePlus

Scheme showing the mechanism of BIO release within the hydrogel after injection into the MI area.Abbreviations: BIO, 6-bromoindirubin-3-oxime; IGF-1, insulin-like growth factor 1; MI, myocardial infarction.
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f7-ijn-10-4691: Scheme showing the mechanism of BIO release within the hydrogel after injection into the MI area.Abbreviations: BIO, 6-bromoindirubin-3-oxime; IGF-1, insulin-like growth factor 1; MI, myocardial infarction.

Mentions: In the present study, we investigated the functional and histological/cellular effects of the intramyocardial administration of BIO and IGF-1 in MI rats. We showed that the improved sustained co-delivery of BIO and IGF-1 by a newly developed hybrid hydrogel system holds potential as a novel treatment for MI. Six weeks after delivery, BIO and IGF-1 treatment led to the proliferation of resident cardiac cells and promoted revascularization. Importantly, the repair and regeneration of the damaged myocardial tissues was associated with significant improvements in cardiac function (Figure 7).


Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts.

Fang R, Qiao S, Liu Y, Meng Q, Chen X, Song B, Hou X, Tian W - Int J Nanomedicine (2015)

Scheme showing the mechanism of BIO release within the hydrogel after injection into the MI area.Abbreviations: BIO, 6-bromoindirubin-3-oxime; IGF-1, insulin-like growth factor 1; MI, myocardial infarction.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524466&req=5

f7-ijn-10-4691: Scheme showing the mechanism of BIO release within the hydrogel after injection into the MI area.Abbreviations: BIO, 6-bromoindirubin-3-oxime; IGF-1, insulin-like growth factor 1; MI, myocardial infarction.
Mentions: In the present study, we investigated the functional and histological/cellular effects of the intramyocardial administration of BIO and IGF-1 in MI rats. We showed that the improved sustained co-delivery of BIO and IGF-1 by a newly developed hybrid hydrogel system holds potential as a novel treatment for MI. Six weeks after delivery, BIO and IGF-1 treatment led to the proliferation of resident cardiac cells and promoted revascularization. Importantly, the repair and regeneration of the damaged myocardial tissues was associated with significant improvements in cardiac function (Figure 7).

Bottom Line: Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation.However, their delivery for sustained release in MI-affected areas has proved to be challenging.Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization.

View Article: PubMed Central - PubMed

Affiliation: Bio-X Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin, People's Republic of China ; Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada.

ABSTRACT
Dedifferentiation and proliferation of endogenous cardiomyocytes in situ can effectively improve cardiac repair following myocardial infarction (MI). 6-Bromoindirubin-3-oxime (BIO) and insulin-like growth factor 1 (IGF-1) are two potent factors that promote cardiomyocyte survival and proliferation. However, their delivery for sustained release in MI-affected areas has proved to be challenging. In the current research, we present a study on the sustained co-delivery of BIO and IGF-1 in a hybrid hydrogel system to simulate endogenous cardiac repair in an MI rat model. Both BIO and IGF-1 were efficiently encapsulated in gelatin nanoparticles, which were later cross-linked with the oxidized alginate to form a novel hybrid hydrogel system. The in vivo results indicated that the hybrid system could enhance the proliferation of cardiomyocytes in situ and could promote revascularization around the MI sites, allowing improved cardiac function. Taken together, we concluded that the hybrid hydrogel system can co-deliver BIO and IGF-1 to areas of MI and thus improve cardiac function by promoting the proliferation of cardiomyocytes and revascularization.

No MeSH data available.


Related in: MedlinePlus