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Dynamics of preventive vs post-diagnostic cancer control using low-impact measures.

Akhmetzhanov AR, Hochberg ME - Elife (2015)

Bottom Line: Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs.We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected.Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth.

View Article: PubMed Central - PubMed

Affiliation: Institut des Sciences de l'Evolution de Montpellier, University of Montpellier, Montpellier, France.

ABSTRACT
Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs. We currently lack quantitative theory for how preventive measures and post-diagnostic interventions are predicted to affect risks of a life threatening cancer. Here we evaluate how continuous measures, such as life style changes and traditional treatments, affect both neoplastic growth and the frequency of resistant clones. We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected. Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth. We discuss these results and other important mitigating factors that should be taken into consideration in a comparative understanding of preventive and post-diagnostic interventions.

No MeSH data available.


Related in: MedlinePlus

Maximal tumour heterogeneity in terms of driver subclones occurs at intermediate times after initial lesion.DOI:http://dx.doi.org/10.7554/eLife.06266.027
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fig9: Maximal tumour heterogeneity in terms of driver subclones occurs at intermediate times after initial lesion.DOI:http://dx.doi.org/10.7554/eLife.06266.027

Mentions: The distribution Pi∗(t) for a particular case of N = 6 is shown in Appendix 1—figure 3.10.7554/eLife.06266.027Appendix 1—figure 3.Maximal tumour heterogeneity in terms of driver subclones occurs at intermediate times after initial lesion.


Dynamics of preventive vs post-diagnostic cancer control using low-impact measures.

Akhmetzhanov AR, Hochberg ME - Elife (2015)

Maximal tumour heterogeneity in terms of driver subclones occurs at intermediate times after initial lesion.DOI:http://dx.doi.org/10.7554/eLife.06266.027
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524440&req=5

fig9: Maximal tumour heterogeneity in terms of driver subclones occurs at intermediate times after initial lesion.DOI:http://dx.doi.org/10.7554/eLife.06266.027
Mentions: The distribution Pi∗(t) for a particular case of N = 6 is shown in Appendix 1—figure 3.10.7554/eLife.06266.027Appendix 1—figure 3.Maximal tumour heterogeneity in terms of driver subclones occurs at intermediate times after initial lesion.

Bottom Line: Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs.We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected.Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth.

View Article: PubMed Central - PubMed

Affiliation: Institut des Sciences de l'Evolution de Montpellier, University of Montpellier, Montpellier, France.

ABSTRACT
Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs. We currently lack quantitative theory for how preventive measures and post-diagnostic interventions are predicted to affect risks of a life threatening cancer. Here we evaluate how continuous measures, such as life style changes and traditional treatments, affect both neoplastic growth and the frequency of resistant clones. We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected. Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth. We discuss these results and other important mitigating factors that should be taken into consideration in a comparative understanding of preventive and post-diagnostic interventions.

No MeSH data available.


Related in: MedlinePlus