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Evaluation of a topical treatment for the relief of sensitive skin.

Heinicke IR, Adams DH, Barnes TM, Greive KA - Clin Cosmet Investig Dermatol (2015)

Bottom Line: Further, the formulation was found to be nonstinging, nonirritating, and noncomedogenic.No adverse events were observed.In this study, Rescue Gel has been shown to exhibit properties that make it effective for use on sensitive or irritated facial skin, without exacerbation of the symptoms associated with sensitive skin.

View Article: PubMed Central - PubMed

Affiliation: Ego Pharmaceuticals, Braeside, VIC, Australia.

ABSTRACT

Background: Approximately, 50% of the population claim to have sensitive skin, which has created an important challenge for dermatologists and the cosmetic industry. This study evaluates the properties of QV Face Rescue Gel (Rescue Gel) that contains a combination of moisturizing and anti-irritant ingredients, and which is used to relieve the symptoms of sensitive facial skin.

Methods: The ability of Rescue Gel to induce collagen types I and III in cultured neonatal human foreskin fibroblasts compared to transforming growth factor beta 1, a known potent inducer of collagen types I and III, was measured using immunofluorescence staining. Furthermore, healthy volunteers were recruited to measure the potential for Rescue Gel to reduce erythema induced by solar-simulated ultraviolet radiation on the skin compared to 0.5% hydrocortisone cream (positive control) as well as it's ability to decrease transepidermal water loss compared to baseline levels. In addition, the formulation was tested for its potential to be 1) nonstinging using a facial sting/discomfort assay performed on volunteers who reacted positively to lactic acid, 2) nonirritating as determined by repeat insult patch tests, and 3) noncomedogenic.

Results: Rescue Gel significantly induced collagen types I and III in cultured human foreskin fibroblasts similarly to transforming growth factor beta 1. In volunteers, Rescue Gel was shown to significantly reduce erythema induced by solar-simulated ultraviolet radiation similarly to 0.5% hydrocortisone, and to significantly reduce transepidermal water loss compared to baseline levels. Further, the formulation was found to be nonstinging, nonirritating, and noncomedogenic. No adverse events were observed.

Conclusion: In this study, Rescue Gel has been shown to exhibit properties that make it effective for use on sensitive or irritated facial skin, without exacerbation of the symptoms associated with sensitive skin.

No MeSH data available.


Related in: MedlinePlus

Mean percentage reduction in TEWL measurements for Rescue Gel over time (hours).Notes: The maximum response at each time point is also shown in the figure. *P<0.05 versus t=0.Abbreviations: TEWL, transepidermal water loss; Rescue Gel, QV Face Rescue Gel.
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f4-ccid-8-405: Mean percentage reduction in TEWL measurements for Rescue Gel over time (hours).Notes: The maximum response at each time point is also shown in the figure. *P<0.05 versus t=0.Abbreviations: TEWL, transepidermal water loss; Rescue Gel, QV Face Rescue Gel.

Mentions: All ten volunteers completed the study with no adverse reactions observed. The preapplication mean TEWL value was 4.57±0.63 g/hm2. Figure 4 illustrates the mean percentage decrease in TEWL over time compared to baseline. Two hours post-application, TEWL significantly decreased by approximately 37% (P=0.026 vs t=0), and by 49% at both t=4 hours (P=0.006 vs t=0) and t=7 hours (P=0.002 vs t=0) post-application compared to baseline. These results show that a significant reduction in water loss was observed 2 hours following the topical application of Rescue Gel, which continued to improve for the duration of the study.


Evaluation of a topical treatment for the relief of sensitive skin.

Heinicke IR, Adams DH, Barnes TM, Greive KA - Clin Cosmet Investig Dermatol (2015)

Mean percentage reduction in TEWL measurements for Rescue Gel over time (hours).Notes: The maximum response at each time point is also shown in the figure. *P<0.05 versus t=0.Abbreviations: TEWL, transepidermal water loss; Rescue Gel, QV Face Rescue Gel.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524272&req=5

f4-ccid-8-405: Mean percentage reduction in TEWL measurements for Rescue Gel over time (hours).Notes: The maximum response at each time point is also shown in the figure. *P<0.05 versus t=0.Abbreviations: TEWL, transepidermal water loss; Rescue Gel, QV Face Rescue Gel.
Mentions: All ten volunteers completed the study with no adverse reactions observed. The preapplication mean TEWL value was 4.57±0.63 g/hm2. Figure 4 illustrates the mean percentage decrease in TEWL over time compared to baseline. Two hours post-application, TEWL significantly decreased by approximately 37% (P=0.026 vs t=0), and by 49% at both t=4 hours (P=0.006 vs t=0) and t=7 hours (P=0.002 vs t=0) post-application compared to baseline. These results show that a significant reduction in water loss was observed 2 hours following the topical application of Rescue Gel, which continued to improve for the duration of the study.

Bottom Line: Further, the formulation was found to be nonstinging, nonirritating, and noncomedogenic.No adverse events were observed.In this study, Rescue Gel has been shown to exhibit properties that make it effective for use on sensitive or irritated facial skin, without exacerbation of the symptoms associated with sensitive skin.

View Article: PubMed Central - PubMed

Affiliation: Ego Pharmaceuticals, Braeside, VIC, Australia.

ABSTRACT

Background: Approximately, 50% of the population claim to have sensitive skin, which has created an important challenge for dermatologists and the cosmetic industry. This study evaluates the properties of QV Face Rescue Gel (Rescue Gel) that contains a combination of moisturizing and anti-irritant ingredients, and which is used to relieve the symptoms of sensitive facial skin.

Methods: The ability of Rescue Gel to induce collagen types I and III in cultured neonatal human foreskin fibroblasts compared to transforming growth factor beta 1, a known potent inducer of collagen types I and III, was measured using immunofluorescence staining. Furthermore, healthy volunteers were recruited to measure the potential for Rescue Gel to reduce erythema induced by solar-simulated ultraviolet radiation on the skin compared to 0.5% hydrocortisone cream (positive control) as well as it's ability to decrease transepidermal water loss compared to baseline levels. In addition, the formulation was tested for its potential to be 1) nonstinging using a facial sting/discomfort assay performed on volunteers who reacted positively to lactic acid, 2) nonirritating as determined by repeat insult patch tests, and 3) noncomedogenic.

Results: Rescue Gel significantly induced collagen types I and III in cultured human foreskin fibroblasts similarly to transforming growth factor beta 1. In volunteers, Rescue Gel was shown to significantly reduce erythema induced by solar-simulated ultraviolet radiation similarly to 0.5% hydrocortisone, and to significantly reduce transepidermal water loss compared to baseline levels. Further, the formulation was found to be nonstinging, nonirritating, and noncomedogenic. No adverse events were observed.

Conclusion: In this study, Rescue Gel has been shown to exhibit properties that make it effective for use on sensitive or irritated facial skin, without exacerbation of the symptoms associated with sensitive skin.

No MeSH data available.


Related in: MedlinePlus