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Prospective investigation of change in the prostate-specific antigens after various urologic procedures.

Park SC, Shin YS, Zhang LT, Kim DS, Kim SZ, Park NC, Ahn TY, Kim JJ, Lee SW, So I, Park JK - Clin Interv Aging (2015)

Bottom Line: The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels.There was no significant increase in total and free PSA levels in the serum after DRE and TRUS.The total and free PSA levels were increased significantly from 10 minutes after procedures, except DRE and TRUS, and were increased to maximal level at 60 minutes after procedures.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Wonkwang University School of Medicine and Hospital, Iksan, South Korea.

ABSTRACT

Purpose: Prostate-specific antigen (PSA) is the most important marker in the diagnosis and follow-up of patients with prostate cancer. The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels.

Subjects and methods: A series of 62 patients (8 after digital rectal examination [DRE], 12 after transrectal ultrasonography [TRUS], 11 after rigid cystoscopy, 13 after prostatic massage, 8 after TRUS-guided prostate biopsy, and 10 after transurethral resection of prostate [TURP]) were enrolled in the study. Blood samples were taken from each patient before procedure and at 10, 30, 60, and 120 minutes after procedures.

Results: Prostate massage, rigid cystoscopy, TURP, and TRUS-guided prostate biopsy caused statistically significant rise in total and free PSA levels in the serum. There was no significant increase in total and free PSA levels in the serum after DRE and TRUS. The mean differences were greater for free PSA level in the serum for TURP, TRUS-guided prostate biopsy, prostate massage, and rigid cystoscopy.

Conclusion: Total and free PSA levels in the serum are altered by prostate massage, rigid cystoscopy, TRUS-guided prostate biopsy, and TURP. The PSA rises were related to the stimulation strength of the procedures. The total and free PSA levels were increased significantly from 10 minutes after procedures, except DRE and TRUS, and were increased to maximal level at 60 minutes after procedures.

No MeSH data available.


Related in: MedlinePlus

The changes in total and free PSA levels in the serum before and after procedures.Notes: (A) The median PSA level after DRE, (B) TRUS, (C) prostate massage, (D) rigid cystoscopy, (E) prostate biopsy, and (F) TURP. *P<0.05 by Wilcoxon signed-rank test. **P<0.01 by Wilcoxon signed-rank test.Abbreviations: DRE, digital rectal examination; PSA, prostate-specific antigen; TRUS, transrectal ultrasonography; TURP, transurethral resection of the prostate; TPSA, total prostate-specific antigen; FPSA, free prostate-specific antigen.
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f1-cia-10-1213: The changes in total and free PSA levels in the serum before and after procedures.Notes: (A) The median PSA level after DRE, (B) TRUS, (C) prostate massage, (D) rigid cystoscopy, (E) prostate biopsy, and (F) TURP. *P<0.05 by Wilcoxon signed-rank test. **P<0.01 by Wilcoxon signed-rank test.Abbreviations: DRE, digital rectal examination; PSA, prostate-specific antigen; TRUS, transrectal ultrasonography; TURP, transurethral resection of the prostate; TPSA, total prostate-specific antigen; FPSA, free prostate-specific antigen.

Mentions: After prostate massage, rigid cystoscopy, and TURP, the total and free PSA levels increased significantly from 10 minutes after procedures (P<0.01; Tables 2 and 3, Figure 1). And TRUS-guided prostate biopsy also caused the total and free PSA to rise significantly from 10 minutes after procedure (P<0.05; Tables 2 and 3, Figure 1). The total and free PSA levels increased to a maximal level at 60 minutes after procedures (Tables 2 and 3, Figure 1). Interestingly, the mean changes were greater for free PSA than total PSA rises (P<0.05). This was most apparent following TURP and TRUS-guided prostate biopsy. But there was no statistically significant change in total and free PSA levels in the serum before and after DRE and TRUS.


Prospective investigation of change in the prostate-specific antigens after various urologic procedures.

Park SC, Shin YS, Zhang LT, Kim DS, Kim SZ, Park NC, Ahn TY, Kim JJ, Lee SW, So I, Park JK - Clin Interv Aging (2015)

The changes in total and free PSA levels in the serum before and after procedures.Notes: (A) The median PSA level after DRE, (B) TRUS, (C) prostate massage, (D) rigid cystoscopy, (E) prostate biopsy, and (F) TURP. *P<0.05 by Wilcoxon signed-rank test. **P<0.01 by Wilcoxon signed-rank test.Abbreviations: DRE, digital rectal examination; PSA, prostate-specific antigen; TRUS, transrectal ultrasonography; TURP, transurethral resection of the prostate; TPSA, total prostate-specific antigen; FPSA, free prostate-specific antigen.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524270&req=5

f1-cia-10-1213: The changes in total and free PSA levels in the serum before and after procedures.Notes: (A) The median PSA level after DRE, (B) TRUS, (C) prostate massage, (D) rigid cystoscopy, (E) prostate biopsy, and (F) TURP. *P<0.05 by Wilcoxon signed-rank test. **P<0.01 by Wilcoxon signed-rank test.Abbreviations: DRE, digital rectal examination; PSA, prostate-specific antigen; TRUS, transrectal ultrasonography; TURP, transurethral resection of the prostate; TPSA, total prostate-specific antigen; FPSA, free prostate-specific antigen.
Mentions: After prostate massage, rigid cystoscopy, and TURP, the total and free PSA levels increased significantly from 10 minutes after procedures (P<0.01; Tables 2 and 3, Figure 1). And TRUS-guided prostate biopsy also caused the total and free PSA to rise significantly from 10 minutes after procedure (P<0.05; Tables 2 and 3, Figure 1). The total and free PSA levels increased to a maximal level at 60 minutes after procedures (Tables 2 and 3, Figure 1). Interestingly, the mean changes were greater for free PSA than total PSA rises (P<0.05). This was most apparent following TURP and TRUS-guided prostate biopsy. But there was no statistically significant change in total and free PSA levels in the serum before and after DRE and TRUS.

Bottom Line: The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels.There was no significant increase in total and free PSA levels in the serum after DRE and TRUS.The total and free PSA levels were increased significantly from 10 minutes after procedures, except DRE and TRUS, and were increased to maximal level at 60 minutes after procedures.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Wonkwang University School of Medicine and Hospital, Iksan, South Korea.

ABSTRACT

Purpose: Prostate-specific antigen (PSA) is the most important marker in the diagnosis and follow-up of patients with prostate cancer. The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels.

Subjects and methods: A series of 62 patients (8 after digital rectal examination [DRE], 12 after transrectal ultrasonography [TRUS], 11 after rigid cystoscopy, 13 after prostatic massage, 8 after TRUS-guided prostate biopsy, and 10 after transurethral resection of prostate [TURP]) were enrolled in the study. Blood samples were taken from each patient before procedure and at 10, 30, 60, and 120 minutes after procedures.

Results: Prostate massage, rigid cystoscopy, TURP, and TRUS-guided prostate biopsy caused statistically significant rise in total and free PSA levels in the serum. There was no significant increase in total and free PSA levels in the serum after DRE and TRUS. The mean differences were greater for free PSA level in the serum for TURP, TRUS-guided prostate biopsy, prostate massage, and rigid cystoscopy.

Conclusion: Total and free PSA levels in the serum are altered by prostate massage, rigid cystoscopy, TRUS-guided prostate biopsy, and TURP. The PSA rises were related to the stimulation strength of the procedures. The total and free PSA levels were increased significantly from 10 minutes after procedures, except DRE and TRUS, and were increased to maximal level at 60 minutes after procedures.

No MeSH data available.


Related in: MedlinePlus