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Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam.

Geoghegan JL, Tan le V, Kühnert D, Halpin RA, Lin X, Simenauer A, Akopov A, Das SR, Stockwell TB, Shrivastava S, Ngoc NM, Uyen le TT, Tuyen NT, Thanh TT, Hang VT, Qui PT, Hung NT, Khanh TH, Thinh le Q, Nhan le NT, Van HM, Viet do C, Tuan HM, Viet HL, Hien TT, Chau NV, Thwaites G, Grenfell BT, Stadler T, Wentworth DE, Holmes EC, Van Doorn HR - J. Virol. (2015)

Bottom Line: We show that the Re of subgenogroup C4 decreased during the time frame of sampling, whereas that of B5 increased and remained >1 at the end of 2013, corresponding to a rise in B5 prevalence.HFMD usually causes only mild illness with no long-term consequences.Although major advances have been made in the development of a potential EV-A71 vaccine, there is no current prevention and little is known about the patterns and dynamics of EV-A71 spread.

View Article: PubMed Central - PubMed

Affiliation: Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia jemma.geoghegan@sydney.edu.au tanlv@oucru.org.

No MeSH data available.


Related in: MedlinePlus

MCC tree of 190 whole-genome EV-A71 sequences sampled from 18 provinces in Viet Nam between 2011 and 2013. Branches are color-coded according to location of sampling.
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Figure 2: MCC tree of 190 whole-genome EV-A71 sequences sampled from 18 provinces in Viet Nam between 2011 and 2013. Branches are color-coded according to location of sampling.

Mentions: (A) MCC tree of 1,176 complete VP1 sequences. The phylogeny includes 200 sequences from Viet Nam, as well as 976 randomly selected sequences from GenBank, sampled from 10 discrete locations in Southeast Asia (China, Hong Kong, Japan, South Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand, and Viet Nam) between 1997 and 2013. Branches are color-coded according to the location of sampling. Asterisks indicate the two major subgenogroups from Viet Nam sampled in the present study. (B) Bayesian skyride plots, illustrating the relative genetic diversity of genogroups B (blue) and C (red) through time. A dashed line indicates the mean while shaded areas show the upper and lower 95% HPD values. (C) The temporal distribution of the different subgenogroups circulating in the region (partially adapted from Fig. 2.2 in reference 54). The data are from countries with enhanced surveillance since 1997.


Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam.

Geoghegan JL, Tan le V, Kühnert D, Halpin RA, Lin X, Simenauer A, Akopov A, Das SR, Stockwell TB, Shrivastava S, Ngoc NM, Uyen le TT, Tuyen NT, Thanh TT, Hang VT, Qui PT, Hung NT, Khanh TH, Thinh le Q, Nhan le NT, Van HM, Viet do C, Tuan HM, Viet HL, Hien TT, Chau NV, Thwaites G, Grenfell BT, Stadler T, Wentworth DE, Holmes EC, Van Doorn HR - J. Virol. (2015)

MCC tree of 190 whole-genome EV-A71 sequences sampled from 18 provinces in Viet Nam between 2011 and 2013. Branches are color-coded according to location of sampling.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4524079&req=5

Figure 2: MCC tree of 190 whole-genome EV-A71 sequences sampled from 18 provinces in Viet Nam between 2011 and 2013. Branches are color-coded according to location of sampling.
Mentions: (A) MCC tree of 1,176 complete VP1 sequences. The phylogeny includes 200 sequences from Viet Nam, as well as 976 randomly selected sequences from GenBank, sampled from 10 discrete locations in Southeast Asia (China, Hong Kong, Japan, South Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand, and Viet Nam) between 1997 and 2013. Branches are color-coded according to the location of sampling. Asterisks indicate the two major subgenogroups from Viet Nam sampled in the present study. (B) Bayesian skyride plots, illustrating the relative genetic diversity of genogroups B (blue) and C (red) through time. A dashed line indicates the mean while shaded areas show the upper and lower 95% HPD values. (C) The temporal distribution of the different subgenogroups circulating in the region (partially adapted from Fig. 2.2 in reference 54). The data are from countries with enhanced surveillance since 1997.

Bottom Line: We show that the Re of subgenogroup C4 decreased during the time frame of sampling, whereas that of B5 increased and remained >1 at the end of 2013, corresponding to a rise in B5 prevalence.HFMD usually causes only mild illness with no long-term consequences.Although major advances have been made in the development of a potential EV-A71 vaccine, there is no current prevention and little is known about the patterns and dynamics of EV-A71 spread.

View Article: PubMed Central - PubMed

Affiliation: Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia jemma.geoghegan@sydney.edu.au tanlv@oucru.org.

No MeSH data available.


Related in: MedlinePlus