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Normal Values of Diffusion Tensor Magnetic Resonance Imaging Parameters in the Cervical Spinal Cord.

Chagawa K, Nishijima S, Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Taguchi T - Asian Spine J (2015)

Bottom Line: ADC was significantly higher in subjects >40 years of age than in those ≤40 years.There was no significant difference in FA values between the two groups.The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.

ABSTRACT

Study design: Prospective study.

Purpose: We evaluated the usefulness of diffusion tensor imaging (DTI) in diagnosing patients with cervical myelopathy by determining the accuracy of normal DTI parameter values.

Overview of literature: DTI can visualize white matter tracts in vivo and quantify anisotropy. DTI is known to be more sensitive than conventional magnetic resonance imaging (MRI) in detecting subtle pathological changes of the spinal cord.

Methods: A total of 31 normal subjects (13 men and 18 women; age, 23-87 years; mean age, 46.0 years) were included in this study. The patients had no symptoms of myelopathy or radiculopathy. A Philips Achieva 3-Tesla MRI with SE-type Single Shot EPI was used to obtain diffusion tensor images. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured as DTI parameters on axial sections of several cervical levels. Subjects were divided into two groups: >40 years (n=16) and ≤40 years (n=15). A paired t-test was used to compare significant differences between the groups. ADC and FA values were most stable on axial sections.

Results: For all subjects, mean ADC and FA values were 1.06±0.09×10(-3) mm(2)/sec and 0.68±0.05, respectively. ADC was significantly higher in subjects >40 years of age than in those ≤40 years. There was no significant difference in FA values between the two groups. The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

Conclusions: It is important to consider age when evaluating cervical myelopathy by DTI.

No MeSH data available.


Related in: MedlinePlus

(A) Apparent diffusion coefficient (ADC) was significantly higher in subjects >40 years of age than in those ≤40 years (p=0.04). (B) ADC was positively correlated with age by using Spearman rank correlation coefficient test (p=0.02). (C) Fractional anisotropy (FA) was not significantly influenced by age (p=0.07). (D) Spearman's rank correlation coefficient test showed that there was a weak negative correlation between the FA and age. However, the correlation was not statistically significant (p=0.14). (E) Pearson's correlation coefficient test showed that there was a weak negative correlation between the ADC and FA. However, the correlation was not statistically significant (p=0.07). (F) There was no significant difference in the ADC between males and females (p=0.24). (G) There was no significant difference in the FA between males and females (p=0.051).
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Figure 4: (A) Apparent diffusion coefficient (ADC) was significantly higher in subjects >40 years of age than in those ≤40 years (p=0.04). (B) ADC was positively correlated with age by using Spearman rank correlation coefficient test (p=0.02). (C) Fractional anisotropy (FA) was not significantly influenced by age (p=0.07). (D) Spearman's rank correlation coefficient test showed that there was a weak negative correlation between the FA and age. However, the correlation was not statistically significant (p=0.14). (E) Pearson's correlation coefficient test showed that there was a weak negative correlation between the ADC and FA. However, the correlation was not statistically significant (p=0.07). (F) There was no significant difference in the ADC between males and females (p=0.24). (G) There was no significant difference in the FA between males and females (p=0.051).

Mentions: Next, we compared normal ADC and FA values according to age. ADC values were significantly higher in the subjects >40 years of age than in those ≤40 years (p=0.04) (Fig. 4A). Spearman rank correlation coefficient test showed that ADC was positively correlated with age (p=0.02) (Fig. 4B).


Normal Values of Diffusion Tensor Magnetic Resonance Imaging Parameters in the Cervical Spinal Cord.

Chagawa K, Nishijima S, Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Taguchi T - Asian Spine J (2015)

(A) Apparent diffusion coefficient (ADC) was significantly higher in subjects >40 years of age than in those ≤40 years (p=0.04). (B) ADC was positively correlated with age by using Spearman rank correlation coefficient test (p=0.02). (C) Fractional anisotropy (FA) was not significantly influenced by age (p=0.07). (D) Spearman's rank correlation coefficient test showed that there was a weak negative correlation between the FA and age. However, the correlation was not statistically significant (p=0.14). (E) Pearson's correlation coefficient test showed that there was a weak negative correlation between the ADC and FA. However, the correlation was not statistically significant (p=0.07). (F) There was no significant difference in the ADC between males and females (p=0.24). (G) There was no significant difference in the FA between males and females (p=0.051).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522443&req=5

Figure 4: (A) Apparent diffusion coefficient (ADC) was significantly higher in subjects >40 years of age than in those ≤40 years (p=0.04). (B) ADC was positively correlated with age by using Spearman rank correlation coefficient test (p=0.02). (C) Fractional anisotropy (FA) was not significantly influenced by age (p=0.07). (D) Spearman's rank correlation coefficient test showed that there was a weak negative correlation between the FA and age. However, the correlation was not statistically significant (p=0.14). (E) Pearson's correlation coefficient test showed that there was a weak negative correlation between the ADC and FA. However, the correlation was not statistically significant (p=0.07). (F) There was no significant difference in the ADC between males and females (p=0.24). (G) There was no significant difference in the FA between males and females (p=0.051).
Mentions: Next, we compared normal ADC and FA values according to age. ADC values were significantly higher in the subjects >40 years of age than in those ≤40 years (p=0.04) (Fig. 4A). Spearman rank correlation coefficient test showed that ADC was positively correlated with age (p=0.02) (Fig. 4B).

Bottom Line: ADC was significantly higher in subjects >40 years of age than in those ≤40 years.There was no significant difference in FA values between the two groups.The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.

ABSTRACT

Study design: Prospective study.

Purpose: We evaluated the usefulness of diffusion tensor imaging (DTI) in diagnosing patients with cervical myelopathy by determining the accuracy of normal DTI parameter values.

Overview of literature: DTI can visualize white matter tracts in vivo and quantify anisotropy. DTI is known to be more sensitive than conventional magnetic resonance imaging (MRI) in detecting subtle pathological changes of the spinal cord.

Methods: A total of 31 normal subjects (13 men and 18 women; age, 23-87 years; mean age, 46.0 years) were included in this study. The patients had no symptoms of myelopathy or radiculopathy. A Philips Achieva 3-Tesla MRI with SE-type Single Shot EPI was used to obtain diffusion tensor images. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured as DTI parameters on axial sections of several cervical levels. Subjects were divided into two groups: >40 years (n=16) and ≤40 years (n=15). A paired t-test was used to compare significant differences between the groups. ADC and FA values were most stable on axial sections.

Results: For all subjects, mean ADC and FA values were 1.06±0.09×10(-3) mm(2)/sec and 0.68±0.05, respectively. ADC was significantly higher in subjects >40 years of age than in those ≤40 years. There was no significant difference in FA values between the two groups. The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

Conclusions: It is important to consider age when evaluating cervical myelopathy by DTI.

No MeSH data available.


Related in: MedlinePlus