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Normal Values of Diffusion Tensor Magnetic Resonance Imaging Parameters in the Cervical Spinal Cord.

Chagawa K, Nishijima S, Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Taguchi T - Asian Spine J (2015)

Bottom Line: ADC was significantly higher in subjects >40 years of age than in those ≤40 years.There was no significant difference in FA values between the two groups.The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.

ABSTRACT

Study design: Prospective study.

Purpose: We evaluated the usefulness of diffusion tensor imaging (DTI) in diagnosing patients with cervical myelopathy by determining the accuracy of normal DTI parameter values.

Overview of literature: DTI can visualize white matter tracts in vivo and quantify anisotropy. DTI is known to be more sensitive than conventional magnetic resonance imaging (MRI) in detecting subtle pathological changes of the spinal cord.

Methods: A total of 31 normal subjects (13 men and 18 women; age, 23-87 years; mean age, 46.0 years) were included in this study. The patients had no symptoms of myelopathy or radiculopathy. A Philips Achieva 3-Tesla MRI with SE-type Single Shot EPI was used to obtain diffusion tensor images. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured as DTI parameters on axial sections of several cervical levels. Subjects were divided into two groups: >40 years (n=16) and ≤40 years (n=15). A paired t-test was used to compare significant differences between the groups. ADC and FA values were most stable on axial sections.

Results: For all subjects, mean ADC and FA values were 1.06±0.09×10(-3) mm(2)/sec and 0.68±0.05, respectively. ADC was significantly higher in subjects >40 years of age than in those ≤40 years. There was no significant difference in FA values between the two groups. The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

Conclusions: It is important to consider age when evaluating cervical myelopathy by DTI.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging techniques. (A) Anatomical scan (T2-weighted fast spin echo image). (B) Apparent diffusion coefficient (ADC map; axial view). (C) ADC (region of interest). (D) Fractional anisotropy (FA map; axial view). (E) Fractional anisotropy (region of interest).
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Figure 1: Magnetic resonance imaging techniques. (A) Anatomical scan (T2-weighted fast spin echo image). (B) Apparent diffusion coefficient (ADC map; axial view). (C) ADC (region of interest). (D) Fractional anisotropy (FA map; axial view). (E) Fractional anisotropy (region of interest).

Mentions: As shown in Fig. 1, both ADC and FA images were taken, and intraspinal ADC and FA values were measured between each vertebra from the C1/2 to C6/7 level using an axial image that gave stable values. Because DTI is incapable of capturing an image of multiple stacks simultaneously, individual slices were generated at the C4/5 level (a preferred site) as a reference (Fig. 1A). The region of interest was identified manually in the spinal axial view but did not involve the spinal edge to achieve stable values (Fig. 1B-E).


Normal Values of Diffusion Tensor Magnetic Resonance Imaging Parameters in the Cervical Spinal Cord.

Chagawa K, Nishijima S, Kanchiku T, Imajo Y, Suzuki H, Yoshida Y, Taguchi T - Asian Spine J (2015)

Magnetic resonance imaging techniques. (A) Anatomical scan (T2-weighted fast spin echo image). (B) Apparent diffusion coefficient (ADC map; axial view). (C) ADC (region of interest). (D) Fractional anisotropy (FA map; axial view). (E) Fractional anisotropy (region of interest).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522443&req=5

Figure 1: Magnetic resonance imaging techniques. (A) Anatomical scan (T2-weighted fast spin echo image). (B) Apparent diffusion coefficient (ADC map; axial view). (C) ADC (region of interest). (D) Fractional anisotropy (FA map; axial view). (E) Fractional anisotropy (region of interest).
Mentions: As shown in Fig. 1, both ADC and FA images were taken, and intraspinal ADC and FA values were measured between each vertebra from the C1/2 to C6/7 level using an axial image that gave stable values. Because DTI is incapable of capturing an image of multiple stacks simultaneously, individual slices were generated at the C4/5 level (a preferred site) as a reference (Fig. 1A). The region of interest was identified manually in the spinal axial view but did not involve the spinal edge to achieve stable values (Fig. 1B-E).

Bottom Line: ADC was significantly higher in subjects >40 years of age than in those ≤40 years.There was no significant difference in FA values between the two groups.The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.

ABSTRACT

Study design: Prospective study.

Purpose: We evaluated the usefulness of diffusion tensor imaging (DTI) in diagnosing patients with cervical myelopathy by determining the accuracy of normal DTI parameter values.

Overview of literature: DTI can visualize white matter tracts in vivo and quantify anisotropy. DTI is known to be more sensitive than conventional magnetic resonance imaging (MRI) in detecting subtle pathological changes of the spinal cord.

Methods: A total of 31 normal subjects (13 men and 18 women; age, 23-87 years; mean age, 46.0 years) were included in this study. The patients had no symptoms of myelopathy or radiculopathy. A Philips Achieva 3-Tesla MRI with SE-type Single Shot EPI was used to obtain diffusion tensor images. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured as DTI parameters on axial sections of several cervical levels. Subjects were divided into two groups: >40 years (n=16) and ≤40 years (n=15). A paired t-test was used to compare significant differences between the groups. ADC and FA values were most stable on axial sections.

Results: For all subjects, mean ADC and FA values were 1.06±0.09×10(-3) mm(2)/sec and 0.68±0.05, respectively. ADC was significantly higher in subjects >40 years of age than in those ≤40 years. There was no significant difference in FA values between the two groups. The mean ADC value was significantly higher in normal subjects >40 years of age than in those ≤40 years.

Conclusions: It is important to consider age when evaluating cervical myelopathy by DTI.

No MeSH data available.


Related in: MedlinePlus