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Distinctive Characteristic Features of Intramedullary Hemangiopericytomas.

Türk CÇ, Kara NN, Süren D, Özdöl Ç, Gediz T, Yıldız S - Asian Spine J (2015)

Bottom Line: All tumors were completely removed, and only two cases received radiotherapy.No recurrence was reported.Complete resection of the intramedullary HPCs seems to be the best management strategy for long-term and recurrence-free survival and in alleviating further need for radiotherapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Ministry of Health, Antalya Education and Research Hospital, Antalya, Turkey.

ABSTRACT

Study design: The retrospective analysis of intramedullary hemangiopericytomas (HPCs) was performed, and the entity was discussed in accordance with the literature findings.

Purpose: This study aimed at defining distinctive characteristic features of intramedullary HPC with respect to surgical approach and prognosis.

Overview of literature: Intramedullary HPCs are extremely rare tumors. They originate from capillary pericytes, supposedly follow the vessels over the spinal cord, and infiltrate deep into the spinal cord without a distinct plane. Their treatments and prognosis are not well-defined in the literature.

Methods: Our database was retrospectively reviewed for the cases of HPCs. Later on, a literature search was performed to reveal all reported cases of intramedullary HPCs. The following key words were searched in PubMed databases: "hemangiopericytoma and intramedullary," "hemangiopericytoma and spine (spinal) and intradural," and "hemangiopericytoma and spinal cord." The articles were reviewed for patients' demographics features, imaging characteristics, tumor-specific factors (surgical technique, pathological descriptions, and world health organization grades), and postoperative course and prognosis (adjuvant therapies, recurrences, complications, and mortalities).

Results: A total of seven patients (three male and four female) was reached, with their ages ranging from 15 to 80 years (mean, 32.5 years). The tumors were located majorly in thoracic region (5/7, 71.4%), and only two cases were in the cervical region (2/7, 28.6%). All tumors were completely removed, and only two cases received radiotherapy. No recurrence was reported.

Conclusions: Complete resection of the intramedullary HPCs seems to be the best management strategy for long-term and recurrence-free survival and in alleviating further need for radiotherapy.

No MeSH data available.


Related in: MedlinePlus

(A) Stag-horn vascular structures and neoplastic stromal cells around the slit shaped vascular structures (H&E, ×100) are shown. (B) Repellent infiltration to glial tissue can be discriminated with GFAP (glial fibrillary acidic protein, ×40).
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Figure 5: (A) Stag-horn vascular structures and neoplastic stromal cells around the slit shaped vascular structures (H&E, ×100) are shown. (B) Repellent infiltration to glial tissue can be discriminated with GFAP (glial fibrillary acidic protein, ×40).

Mentions: Our search reached a total of 233 articles with aforementioned the key words. A total of six articles was identified eligible to be included in the review. Most of the other articles were eliminated, because they consisted of the cases other than intramedullary HPCs. Besides, the publications in languages other than English were excluded, since the characteristic features of the tumor could not be specified. Among these articles, one reported by Ujiie et al. [6] could not been taken into consideration due to language difference (Japanese). Moreover, another article could not be included in this study, because we could not confirm the exact location of the tumor from the figures in the article, although it was reported to be in the intramedullary region at L4-S1 level [7]. Therefore, five cases from four articles in the literature search and two case of our series (Figs. 1, 2, 3, 4, 5) were considered, which makes it a total of seven cases included in the review (Table 1) [58910].


Distinctive Characteristic Features of Intramedullary Hemangiopericytomas.

Türk CÇ, Kara NN, Süren D, Özdöl Ç, Gediz T, Yıldız S - Asian Spine J (2015)

(A) Stag-horn vascular structures and neoplastic stromal cells around the slit shaped vascular structures (H&E, ×100) are shown. (B) Repellent infiltration to glial tissue can be discriminated with GFAP (glial fibrillary acidic protein, ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522440&req=5

Figure 5: (A) Stag-horn vascular structures and neoplastic stromal cells around the slit shaped vascular structures (H&E, ×100) are shown. (B) Repellent infiltration to glial tissue can be discriminated with GFAP (glial fibrillary acidic protein, ×40).
Mentions: Our search reached a total of 233 articles with aforementioned the key words. A total of six articles was identified eligible to be included in the review. Most of the other articles were eliminated, because they consisted of the cases other than intramedullary HPCs. Besides, the publications in languages other than English were excluded, since the characteristic features of the tumor could not be specified. Among these articles, one reported by Ujiie et al. [6] could not been taken into consideration due to language difference (Japanese). Moreover, another article could not be included in this study, because we could not confirm the exact location of the tumor from the figures in the article, although it was reported to be in the intramedullary region at L4-S1 level [7]. Therefore, five cases from four articles in the literature search and two case of our series (Figs. 1, 2, 3, 4, 5) were considered, which makes it a total of seven cases included in the review (Table 1) [58910].

Bottom Line: All tumors were completely removed, and only two cases received radiotherapy.No recurrence was reported.Complete resection of the intramedullary HPCs seems to be the best management strategy for long-term and recurrence-free survival and in alleviating further need for radiotherapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Ministry of Health, Antalya Education and Research Hospital, Antalya, Turkey.

ABSTRACT

Study design: The retrospective analysis of intramedullary hemangiopericytomas (HPCs) was performed, and the entity was discussed in accordance with the literature findings.

Purpose: This study aimed at defining distinctive characteristic features of intramedullary HPC with respect to surgical approach and prognosis.

Overview of literature: Intramedullary HPCs are extremely rare tumors. They originate from capillary pericytes, supposedly follow the vessels over the spinal cord, and infiltrate deep into the spinal cord without a distinct plane. Their treatments and prognosis are not well-defined in the literature.

Methods: Our database was retrospectively reviewed for the cases of HPCs. Later on, a literature search was performed to reveal all reported cases of intramedullary HPCs. The following key words were searched in PubMed databases: "hemangiopericytoma and intramedullary," "hemangiopericytoma and spine (spinal) and intradural," and "hemangiopericytoma and spinal cord." The articles were reviewed for patients' demographics features, imaging characteristics, tumor-specific factors (surgical technique, pathological descriptions, and world health organization grades), and postoperative course and prognosis (adjuvant therapies, recurrences, complications, and mortalities).

Results: A total of seven patients (three male and four female) was reached, with their ages ranging from 15 to 80 years (mean, 32.5 years). The tumors were located majorly in thoracic region (5/7, 71.4%), and only two cases were in the cervical region (2/7, 28.6%). All tumors were completely removed, and only two cases received radiotherapy. No recurrence was reported.

Conclusions: Complete resection of the intramedullary HPCs seems to be the best management strategy for long-term and recurrence-free survival and in alleviating further need for radiotherapy.

No MeSH data available.


Related in: MedlinePlus