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Simultaneous Esophageal and Gastric Metastases from Lung Cancer.

Park JY, Hong SW, Lee JY, Kim JH, Kang JW, Lee HW, Im JP - Clin Endosc (2015)

Bottom Line: During the treatment period, dysphagia and melena newly developed.Upper GI endoscopy revealed geographic erosion at the distal esophagus and multiple volcano-shaped ulcers on the stomach body.Endoscopic biopsy was performed for each lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT
We report of a patient with metastatic adenocarcinoma of the esophagus and stomach from lung cancer. The patient was a 68-year-old man receiving radiotherapy and chemotherapy for stage IV lung cancer, without metastases to the gastrointestinal (GI) tract at the time of the initial diagnosis. During the treatment period, dysphagia and melena newly developed. Upper GI endoscopy revealed geographic erosion at the distal esophagus and multiple volcano-shaped ulcers on the stomach body. Endoscopic biopsy was performed for each lesion. To determine whether the lesions were primary esophageal and gastric cancer masses or metastases from the lung cancer, histopathological testing including immunohistochemical staining was performed, and metastasis from lung cancer was confirmed. The disease progressed despite chemotherapy, and the patient died 5 months after the diagnosis of lung cancer. This is a case report of metastatic adenocarcinoma in the esophagus and stomach, which are very rare sites of spread for lung cancer.

No MeSH data available.


Related in: MedlinePlus

Histological and immunohistochemical staining results. The histologic results of the esophageal and gastric metastatic lesions (A, H&E stain, ×200) and right lower paratracheal lymph node (4R) lesions (B, H&E stain, ×100) all showed adenocarcinomas. The immunohistochemical staining of the stomach lesions was positive for thyroid transcriptional factor-1 (C, ×100).
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Figure 2: Histological and immunohistochemical staining results. The histologic results of the esophageal and gastric metastatic lesions (A, H&E stain, ×200) and right lower paratracheal lymph node (4R) lesions (B, H&E stain, ×100) all showed adenocarcinomas. The immunohistochemical staining of the stomach lesions was positive for thyroid transcriptional factor-1 (C, ×100).

Mentions: Endoscopic biopsies were performed at each lesion location, and the histopathological results showed poorly differentiated adenocarcinomas in both. The histologic patterns of the esophageal and gastric metastatic lesions were similar to those of the right lower paratracheal lymph node (4R) lesions, but to determine more precisely whether the lesions were primary esophageal and gastric cancer masses or metastases from the lung cancer, immunohistochemical (IHC) staining was additionally performed. The IHC results showed positive staining for thyroid transcriptional factor-1 (TTF-1) (Fig. 2). These results support the conclusion that the esophageal and gastric lesions were metastases that originated from the lung cancer.


Simultaneous Esophageal and Gastric Metastases from Lung Cancer.

Park JY, Hong SW, Lee JY, Kim JH, Kang JW, Lee HW, Im JP - Clin Endosc (2015)

Histological and immunohistochemical staining results. The histologic results of the esophageal and gastric metastatic lesions (A, H&E stain, ×200) and right lower paratracheal lymph node (4R) lesions (B, H&E stain, ×100) all showed adenocarcinomas. The immunohistochemical staining of the stomach lesions was positive for thyroid transcriptional factor-1 (C, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522427&req=5

Figure 2: Histological and immunohistochemical staining results. The histologic results of the esophageal and gastric metastatic lesions (A, H&E stain, ×200) and right lower paratracheal lymph node (4R) lesions (B, H&E stain, ×100) all showed adenocarcinomas. The immunohistochemical staining of the stomach lesions was positive for thyroid transcriptional factor-1 (C, ×100).
Mentions: Endoscopic biopsies were performed at each lesion location, and the histopathological results showed poorly differentiated adenocarcinomas in both. The histologic patterns of the esophageal and gastric metastatic lesions were similar to those of the right lower paratracheal lymph node (4R) lesions, but to determine more precisely whether the lesions were primary esophageal and gastric cancer masses or metastases from the lung cancer, immunohistochemical (IHC) staining was additionally performed. The IHC results showed positive staining for thyroid transcriptional factor-1 (TTF-1) (Fig. 2). These results support the conclusion that the esophageal and gastric lesions were metastases that originated from the lung cancer.

Bottom Line: During the treatment period, dysphagia and melena newly developed.Upper GI endoscopy revealed geographic erosion at the distal esophagus and multiple volcano-shaped ulcers on the stomach body.Endoscopic biopsy was performed for each lesion.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT
We report of a patient with metastatic adenocarcinoma of the esophagus and stomach from lung cancer. The patient was a 68-year-old man receiving radiotherapy and chemotherapy for stage IV lung cancer, without metastases to the gastrointestinal (GI) tract at the time of the initial diagnosis. During the treatment period, dysphagia and melena newly developed. Upper GI endoscopy revealed geographic erosion at the distal esophagus and multiple volcano-shaped ulcers on the stomach body. Endoscopic biopsy was performed for each lesion. To determine whether the lesions were primary esophageal and gastric cancer masses or metastases from the lung cancer, histopathological testing including immunohistochemical staining was performed, and metastasis from lung cancer was confirmed. The disease progressed despite chemotherapy, and the patient died 5 months after the diagnosis of lung cancer. This is a case report of metastatic adenocarcinoma in the esophagus and stomach, which are very rare sites of spread for lung cancer.

No MeSH data available.


Related in: MedlinePlus