Limits...
Hoarseness as the Presenting Symptom of Visceral Leishmaniasis with Muco-Cutaneous Lesions: A Case Report.

Mortazavi H, Mohebali M, Taslimi Y, Sadeghipour P, Ansari M, Kamyab K, Talebi M, Khamesipour A - Iran J Parasitol (2015 Apr-Jun)

Bottom Line: PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive.The pathogenic agent was identified as Leishmania major by the nested PCR.To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
Herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. At the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the opening of the pharynx and 20 kg weight lost in last one year. The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the dermis by lymphoplasma and histiocytic cells with a loose granuloma formation suggestive of leishmaniasis. Biopsy of mucosal lesions revealed Leishman bodies in dermis. PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive. The pathogenic agent was identified as Leishmania major by the nested PCR. Serologic tests including direct agglutination test (DAT) and indirect immunofluorescence test (IFAT) were positive with high titers of anti-L. infantum antibodies (1:102400 versus 1:800, respectively), indicative of visceral involvement. The patient responded to a combination of miltefosine and meglumine antimoniate (Glucantime®). Visceral involvement due to L. major is rarely reported. To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran.

No MeSH data available.


Related in: MedlinePlus

Skin lesions: erythematous plaque on chin and upper lip
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4522308&req=5

Figure 1: Skin lesions: erythematous plaque on chin and upper lip

Mentions: A 28-year-old otherwise healthy, non-smoking man with the chief complaint of hoarseness from southeastern part of Iran was referred to our dermatology center in May 2014. He had a few indurated, erythematous plaques on his face (chin and upper lip) and legs, a violaceous plaque on his hard palate, and complained of hoarseness for the past 7 years (Fig. 1 and 2). He also complained of dysphagia to solid diet, and about 20 kilograms weight loss in the last year. Hoarseness was the presenting symptom and lasted for about 5 years during the time that the cutaneous lesions were present.


Hoarseness as the Presenting Symptom of Visceral Leishmaniasis with Muco-Cutaneous Lesions: A Case Report.

Mortazavi H, Mohebali M, Taslimi Y, Sadeghipour P, Ansari M, Kamyab K, Talebi M, Khamesipour A - Iran J Parasitol (2015 Apr-Jun)

Skin lesions: erythematous plaque on chin and upper lip
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4522308&req=5

Figure 1: Skin lesions: erythematous plaque on chin and upper lip
Mentions: A 28-year-old otherwise healthy, non-smoking man with the chief complaint of hoarseness from southeastern part of Iran was referred to our dermatology center in May 2014. He had a few indurated, erythematous plaques on his face (chin and upper lip) and legs, a violaceous plaque on his hard palate, and complained of hoarseness for the past 7 years (Fig. 1 and 2). He also complained of dysphagia to solid diet, and about 20 kilograms weight loss in the last year. Hoarseness was the presenting symptom and lasted for about 5 years during the time that the cutaneous lesions were present.

Bottom Line: PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive.The pathogenic agent was identified as Leishmania major by the nested PCR.To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

ABSTRACT
Herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. At the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the opening of the pharynx and 20 kg weight lost in last one year. The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the dermis by lymphoplasma and histiocytic cells with a loose granuloma formation suggestive of leishmaniasis. Biopsy of mucosal lesions revealed Leishman bodies in dermis. PCR was performed on the specimens of skin, bone marrow, mucosa, and saliva, the results were positive. The pathogenic agent was identified as Leishmania major by the nested PCR. Serologic tests including direct agglutination test (DAT) and indirect immunofluorescence test (IFAT) were positive with high titers of anti-L. infantum antibodies (1:102400 versus 1:800, respectively), indicative of visceral involvement. The patient responded to a combination of miltefosine and meglumine antimoniate (Glucantime®). Visceral involvement due to L. major is rarely reported. To the best of our knowledge, probably hoarseness due to L. major has not been previously reported from Iran.

No MeSH data available.


Related in: MedlinePlus