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Sperm DNA fragmentation after radioiodine treatment for differentiated thyroid cancer.

Esquerré-Lamare C, Isus F, Moinard N, Bujan L - Basic Clin Androl (2015)

Bottom Line: Total sperm count was reduced up to 12 months after the second dose of (131)I.Treatment with (131)I induces alterations in sperm chromatin as well as in sperm parameters a short time (3 months) after a first dose of (131)I with persistence of sperm alterations until 12 months after a second dose.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Université de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), TSA 70034, 31059, Toulouse, Cedex 9 France ; CECOS Midi-Pyrénées, Groupe d'Activité de Médecine de la Reproduction, Paule de Viguier University Hospital, Toulouse, France.

ABSTRACT

Background: Treatment of differentiated thyroid cancer usually consists of a total thyroidectomy followed by one or several courses of radioiodine ((131)I). (131)I is known to have deleterious effects on radiation sensitive tissues and irradiation to the testes has been shown after its administration. We investigated effects of such treatment on sperm DNA in a patient with differentiated thyroid carcinoma.

Methods: The patient, a 32-year-old male with differentiated thyroid carcinoma treated by total thyroidectomy and radioiodine therapy, performed 6 semen samples in total, 3 for sperm banking and 3 for semen exploration, that were analysed for classic semen parameters. DNA integrity was analysed by flow cytometry: sperm DNA fragmentation index (DFI) and high DNA stainability (HDS) were analyzed by sperm chromatin structure assay, DNA fragmentation was analyzed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay.

Results: Moderate oligozoospermia was observed as early as 3 months after a first dose of (131)I and became severe at 5 months. Total sperm count was reduced up to 12 months after the second dose of (131)I. Sperm DFI was increased 3.25 months after the first dose of (131)I. All parameters returned to normal values 28 months after the second (131)I dose.

Conclusions: Treatment with (131)I induces alterations in sperm chromatin as well as in sperm parameters a short time (3 months) after a first dose of (131)I with persistence of sperm alterations until 12 months after a second dose. Sperm banking should be recommended before treatment.

No MeSH data available.


Related in: MedlinePlus

Semen exploration according to time after surgery and 131I treatments The upper line represents time in months after the first 131I treatment, the lower line time in months after the second 131I treatment. Numbers in circles represent ejaculates, ex: 1 = 1st ejaculate. 150 mCi131I represents the two treatments by 131I. Total thyroidectomy and Jugular-carotid lymph node dissection represent the two surgeries the patient underwent
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Fig1: Semen exploration according to time after surgery and 131I treatments The upper line represents time in months after the first 131I treatment, the lower line time in months after the second 131I treatment. Numbers in circles represent ejaculates, ex: 1 = 1st ejaculate. 150 mCi131I represents the two treatments by 131I. Total thyroidectomy and Jugular-carotid lymph node dissection represent the two surgeries the patient underwent

Mentions: A 32-year-old man presented with thyroid carcinoma classified pT3N1R1. One month after a total thyroidectomy, he was treated with 150 mCi of radioiodine (131I). A second dose of 150 mCi 131I was administered 7 months later. The patient was referred to the CECOS for sperm banking 3 months after the first dose of 131I and before the scheduled second dose. He was seen twice during the two months after his first sperm banking, and three times after his second dose of 131I, at 12, 28 and 57 months. The patient gave a total of 6 samples, 3 for sperm banking and 3 for exploration (Fig. 1). The present study was carried out in accordance with the Declaration of Helsinski and the patient gave his informed consent for the study. All samples and exposure data were provided by the GERMETHEQUE Biobank (France).Fig. 1


Sperm DNA fragmentation after radioiodine treatment for differentiated thyroid cancer.

Esquerré-Lamare C, Isus F, Moinard N, Bujan L - Basic Clin Androl (2015)

Semen exploration according to time after surgery and 131I treatments The upper line represents time in months after the first 131I treatment, the lower line time in months after the second 131I treatment. Numbers in circles represent ejaculates, ex: 1 = 1st ejaculate. 150 mCi131I represents the two treatments by 131I. Total thyroidectomy and Jugular-carotid lymph node dissection represent the two surgeries the patient underwent
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522285&req=5

Fig1: Semen exploration according to time after surgery and 131I treatments The upper line represents time in months after the first 131I treatment, the lower line time in months after the second 131I treatment. Numbers in circles represent ejaculates, ex: 1 = 1st ejaculate. 150 mCi131I represents the two treatments by 131I. Total thyroidectomy and Jugular-carotid lymph node dissection represent the two surgeries the patient underwent
Mentions: A 32-year-old man presented with thyroid carcinoma classified pT3N1R1. One month after a total thyroidectomy, he was treated with 150 mCi of radioiodine (131I). A second dose of 150 mCi 131I was administered 7 months later. The patient was referred to the CECOS for sperm banking 3 months after the first dose of 131I and before the scheduled second dose. He was seen twice during the two months after his first sperm banking, and three times after his second dose of 131I, at 12, 28 and 57 months. The patient gave a total of 6 samples, 3 for sperm banking and 3 for exploration (Fig. 1). The present study was carried out in accordance with the Declaration of Helsinski and the patient gave his informed consent for the study. All samples and exposure data were provided by the GERMETHEQUE Biobank (France).Fig. 1

Bottom Line: Total sperm count was reduced up to 12 months after the second dose of (131)I.Treatment with (131)I induces alterations in sperm chromatin as well as in sperm parameters a short time (3 months) after a first dose of (131)I with persistence of sperm alterations until 12 months after a second dose.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Université de Toulouse, UPS, Groupe de Recherche en Fertilité Humaine (EA 3694, Human Fertility Research Group), TSA 70034, 31059, Toulouse, Cedex 9 France ; CECOS Midi-Pyrénées, Groupe d'Activité de Médecine de la Reproduction, Paule de Viguier University Hospital, Toulouse, France.

ABSTRACT

Background: Treatment of differentiated thyroid cancer usually consists of a total thyroidectomy followed by one or several courses of radioiodine ((131)I). (131)I is known to have deleterious effects on radiation sensitive tissues and irradiation to the testes has been shown after its administration. We investigated effects of such treatment on sperm DNA in a patient with differentiated thyroid carcinoma.

Methods: The patient, a 32-year-old male with differentiated thyroid carcinoma treated by total thyroidectomy and radioiodine therapy, performed 6 semen samples in total, 3 for sperm banking and 3 for semen exploration, that were analysed for classic semen parameters. DNA integrity was analysed by flow cytometry: sperm DNA fragmentation index (DFI) and high DNA stainability (HDS) were analyzed by sperm chromatin structure assay, DNA fragmentation was analyzed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay.

Results: Moderate oligozoospermia was observed as early as 3 months after a first dose of (131)I and became severe at 5 months. Total sperm count was reduced up to 12 months after the second dose of (131)I. Sperm DFI was increased 3.25 months after the first dose of (131)I. All parameters returned to normal values 28 months after the second (131)I dose.

Conclusions: Treatment with (131)I induces alterations in sperm chromatin as well as in sperm parameters a short time (3 months) after a first dose of (131)I with persistence of sperm alterations until 12 months after a second dose. Sperm banking should be recommended before treatment.

No MeSH data available.


Related in: MedlinePlus