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Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.


Selective hydrogenation of 3-methyl-1-pentyn-3-ol over a Pd catalyst to the desired 3-methyl-1-penten-3-ol (P1) and overhydrogenation to 3-methyl-3-pentanol (P2).23
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sch08: Selective hydrogenation of 3-methyl-1-pentyn-3-ol over a Pd catalyst to the desired 3-methyl-1-penten-3-ol (P1) and overhydrogenation to 3-methyl-3-pentanol (P2).23

Mentions: Among CF techniques, the most significant progress has been made in the field of CF gas-handling reactions in recent years, mainly driven by CF hydrogenation.22 With CF reactors, the handling of hazardous aggressive gases can be safely performed. Moreover, through the fine-tuning of the reaction parameters, selective transformations can be performed faster and more efficiently as compared with conventional methodologies. The selective reductions of alkynes to alkenes have been achieved in a wall-catalyzed segmented flow reactor by catalytic hydrogenation.23 The commercially available fused-silica capillaries contained a 6 μm thick layer of γ-Al2O3 that was pretreated and impregnated with [Pd(OAc)2] solution, which resulted in nanosized Pd particles evenly dispersed on the coating layer. With the application of this tubing, 3-methyl-1-pentyn-3-ol was selectively reduced to 3-methyl-1-penten-3-ol (Scheme 8).


Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Selective hydrogenation of 3-methyl-1-pentyn-3-ol over a Pd catalyst to the desired 3-methyl-1-penten-3-ol (P1) and overhydrogenation to 3-methyl-3-pentanol (P2).23
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522171&req=5

sch08: Selective hydrogenation of 3-methyl-1-pentyn-3-ol over a Pd catalyst to the desired 3-methyl-1-penten-3-ol (P1) and overhydrogenation to 3-methyl-3-pentanol (P2).23
Mentions: Among CF techniques, the most significant progress has been made in the field of CF gas-handling reactions in recent years, mainly driven by CF hydrogenation.22 With CF reactors, the handling of hazardous aggressive gases can be safely performed. Moreover, through the fine-tuning of the reaction parameters, selective transformations can be performed faster and more efficiently as compared with conventional methodologies. The selective reductions of alkynes to alkenes have been achieved in a wall-catalyzed segmented flow reactor by catalytic hydrogenation.23 The commercially available fused-silica capillaries contained a 6 μm thick layer of γ-Al2O3 that was pretreated and impregnated with [Pd(OAc)2] solution, which resulted in nanosized Pd particles evenly dispersed on the coating layer. With the application of this tubing, 3-methyl-1-pentyn-3-ol was selectively reduced to 3-methyl-1-penten-3-ol (Scheme 8).

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.