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Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.


Catalyst structure (a) and reaction scheme (b) relating to the synthesis of γ-nitroaldehydes.15
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sch04: Catalyst structure (a) and reaction scheme (b) relating to the synthesis of γ-nitroaldehydes.15

Mentions: The synthesis of γ-nitroaldehydes is of considerable current interest as they are useful synthons in organic chemistry and drug discovery.14 The stereoselective CF synthesis of γ-nitroaldehydes has been performed with immobilized peptides as catalysts, as outlined in Scheme 4.15


Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Catalyst structure (a) and reaction scheme (b) relating to the synthesis of γ-nitroaldehydes.15
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522171&req=5

sch04: Catalyst structure (a) and reaction scheme (b) relating to the synthesis of γ-nitroaldehydes.15
Mentions: The synthesis of γ-nitroaldehydes is of considerable current interest as they are useful synthons in organic chemistry and drug discovery.14 The stereoselective CF synthesis of γ-nitroaldehydes has been performed with immobilized peptides as catalysts, as outlined in Scheme 4.15

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.