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Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.


CF synthesis of cyclopropane derivatives.29
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sch11: CF synthesis of cyclopropane derivatives.29

Mentions: Gold catalysis is of considerable current interest because of the massive number of unprecedented transformations,28 for example, highly chemoselective and diastereoselective heterogeneous cyclopropanation reactions. The CF synthesis of cyclopropane derivatives has been achieved through the utilization of Au clusters as catalyst (2.0±0.3 nm) encapsulated in a fourth-generation poly(amidoamine) (G4 PAMAM) dendrimer and loaded onto SBA-15, a mesoporous silica support, with a surface area of 760 m2 g−1.29 The reaction is shown in Scheme 11.


Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

CF synthesis of cyclopropane derivatives.29
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522171&req=5

sch11: CF synthesis of cyclopropane derivatives.29
Mentions: Gold catalysis is of considerable current interest because of the massive number of unprecedented transformations,28 for example, highly chemoselective and diastereoselective heterogeneous cyclopropanation reactions. The CF synthesis of cyclopropane derivatives has been achieved through the utilization of Au clusters as catalyst (2.0±0.3 nm) encapsulated in a fourth-generation poly(amidoamine) (G4 PAMAM) dendrimer and loaded onto SBA-15, a mesoporous silica support, with a surface area of 760 m2 g−1.29 The reaction is shown in Scheme 11.

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.