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Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.


Effects of the residence time on the conversion (a) and the selectivity (b) for the CF Heck reaction.21
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fig09: Effects of the residence time on the conversion (a) and the selectivity (b) for the CF Heck reaction.21

Mentions: A multichannel compact reactor was constructed for the synthesis of 1,2-diphenylethane. The reaction parameters were optimized, and a methodology orders of magnitudes faster than batch reactions was developed. Under batch conditions, the selectivity for 1,2-diphenylethene was lower than under CF conditions because a substantial amount of 1,1-diphenylethene was detected too. Nevertheless, under CF conditions the formation of cis-1,2-diphenylethene was also observed, and the residence time affected the selectivity and the conversion. On decrease of the residence time, the conversion was lower, as expected, but the selectivity towards 1,2-diphenylethene rather a 1,1-diphenylethene was increased (Figure 9). This observation suggests that the 1,2-disubstituted compound is the kinetic product. Here an inverse relationship was observed between the conversion and the selectivity.


Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Effects of the residence time on the conversion (a) and the selectivity (b) for the CF Heck reaction.21
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522171&req=5

fig09: Effects of the residence time on the conversion (a) and the selectivity (b) for the CF Heck reaction.21
Mentions: A multichannel compact reactor was constructed for the synthesis of 1,2-diphenylethane. The reaction parameters were optimized, and a methodology orders of magnitudes faster than batch reactions was developed. Under batch conditions, the selectivity for 1,2-diphenylethene was lower than under CF conditions because a substantial amount of 1,1-diphenylethene was detected too. Nevertheless, under CF conditions the formation of cis-1,2-diphenylethene was also observed, and the residence time affected the selectivity and the conversion. On decrease of the residence time, the conversion was lower, as expected, but the selectivity towards 1,2-diphenylethene rather a 1,1-diphenylethene was increased (Figure 9). This observation suggests that the 1,2-disubstituted compound is the kinetic product. Here an inverse relationship was observed between the conversion and the selectivity.

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.