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Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.


Effects of the residence time and the alkene ratio on the CF Heck reaction of 4-chlorobenzotrifluoride and 2,3-dihydrofuran (Scheme 6).19
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fig08: Effects of the residence time and the alkene ratio on the CF Heck reaction of 4-chlorobenzotrifluoride and 2,3-dihydrofuran (Scheme 6).19

Mentions: The results demonstrated that the yield of the monoarylated product improved significantly with the residence time until a plateau was reached at around 5.5 min. Longer residence times led to decreased yields, as a consequence of diarylated byproduct formation (Figure 8). Increase of the alkene excess resulted in higher yields. Optimum conditions were determined as a residence time of 6 min and an alkene excess of 5.0 equivalents, which corresponded to a yield of 83 %.


Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Effects of the residence time and the alkene ratio on the CF Heck reaction of 4-chlorobenzotrifluoride and 2,3-dihydrofuran (Scheme 6).19
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522171&req=5

fig08: Effects of the residence time and the alkene ratio on the CF Heck reaction of 4-chlorobenzotrifluoride and 2,3-dihydrofuran (Scheme 6).19
Mentions: The results demonstrated that the yield of the monoarylated product improved significantly with the residence time until a plateau was reached at around 5.5 min. Longer residence times led to decreased yields, as a consequence of diarylated byproduct formation (Figure 8). Increase of the alkene excess resulted in higher yields. Optimum conditions were determined as a residence time of 6 min and an alkene excess of 5.0 equivalents, which corresponded to a yield of 83 %.

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.