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Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.


Effects of the residence time on the conversion (a) and the selectivity (b) for the RO-RCM of cis-cyclooctene to 1,9-cyclohexadecadiene.35
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fig13: Effects of the residence time on the conversion (a) and the selectivity (b) for the RO-RCM of cis-cyclooctene to 1,9-cyclohexadecadiene.35

Mentions: This reaction is accompanied by side products such as other oligomers and polymers, compounds formed by double bond isomerization and unsymmetrical metathetical cleavage. To avoid the formation of byproducts, a complete reaction-parameter optimization was carried out, with fine-tuning of the pore diameter of the mesoporous support, the substrate concentration, the temperature, and the residence time. Increase of the residence time led to higher conversions (Figure 13 a). However, when the residence time was decreased, the selectivity towards 1,9-cyclohexadecadiene was improved (Figure 3 b).


Strategic Application of Residence-Time Control in Continuous-Flow Reactors.

Mándity IM, Ötvös SB, Fülöp F - ChemistryOpen (2015)

Effects of the residence time on the conversion (a) and the selectivity (b) for the RO-RCM of cis-cyclooctene to 1,9-cyclohexadecadiene.35
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4522171&req=5

fig13: Effects of the residence time on the conversion (a) and the selectivity (b) for the RO-RCM of cis-cyclooctene to 1,9-cyclohexadecadiene.35
Mentions: This reaction is accompanied by side products such as other oligomers and polymers, compounds formed by double bond isomerization and unsymmetrical metathetical cleavage. To avoid the formation of byproducts, a complete reaction-parameter optimization was carried out, with fine-tuning of the pore diameter of the mesoporous support, the substrate concentration, the temperature, and the residence time. Increase of the residence time led to higher conversions (Figure 13 a). However, when the residence time was decreased, the selectivity towards 1,9-cyclohexadecadiene was improved (Figure 3 b).

Bottom Line: As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals.Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity.Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

View Article: PubMed Central - PubMed

Affiliation: Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6, H-6720, Szeged, Hungary.

ABSTRACT
As a sustainable alternative for conventional batch-based synthetic techniques, the concept of continuous-flow processing has emerged in the synthesis of fine chemicals. Systematic tuning of the residence time, a key parameter of continuous-reaction technology, can govern the outcome of a chemical reaction by determining the reaction rate and the conversion and by influencing the product selectivity. This review furnishes a brief insight into flow reactions in which high chemo- and/or stereoselectivity can be attained by strategic residence-time control and illustrates the importance of the residence time as a crucial parameter in sustainable method development. Such a fine reaction control cannot be performed in conventional batch reaction set-ups.

No MeSH data available.