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Graphical Abstract: ChemistryOpen 3/2015.

- ChemistryOpen (2015)

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ChemistryOPEN is a multidisciplinary, gold-road, open-access, international forum for the publication of Reviews, Full Papers and Communications from all areas of chemistry and related fields... Based in Europe, ChemistryOpen attracts authors and readers from around the world, as open-access publishing becomes more important in all areas of chemistry... The cover picture shows hydrogen bonds in the adenine–thymine (AT) Watson– Crick base pair... Ferric Phosphate Hydroxide Microstructures Affect Their Magnetic Properties Chitosan thin films were developed on polysulfone/TiO2 composite membranes and were characterized by IR spectroscopy, XRD, SEM, contact angle measurement, and water uptake studies... The resulting membranes were used for the reduction of toxic CrVI to CrIII, which can then be adsorbed to the surface... This joint theoretical and experimental study shows that an N-allylmodified 5’ cap found in mRNA can be reacted with tetrazoles in a photoclick reaction... The combination of enzymatic allylation and photoclick chemistry generates a turn-on fluorophore specifically at the 5’ cap found in eukaryotic mRNAs... Revisiting Aromaticity and Chemical Bonding of Fluorinated Benzene Derivatives Here, we analyzed the electron delocalization in fluorinated benzene derivatives (C6H(6¢n)Fn) in terms of the induced magnetic field, nucleus-independent chemical shift (NICS), and ring current strength (RCS)... Fluorination was found to decrease the paratropic ring current through inductive effects and to decrease the diatropic ring current through resonance effects, and the balance between these two effects decreases aromaticity with increased fluorination... Influence of Polarity and Activation Energy in Microwave–Assisted Organic Synthesis (MAOS) This work sought to determine parameters that have decisive roles in microwave-assisted organic reactions (MAOS) and to develop a model, using computational chemistry, to predict the type of reactions that can be improved by using microwave irradiation... Parameters such as polarity, activation energy, and enthalpy were found to be important in the improvement of MAOS... Here we report the design and evaluation of a tumor-specific dendrimer– HDACi... Design and Evaluation of Tumor-Specific Dendrimer Epigenetic Therapeutics 5-styryl-oxathiazol- 2-ones were found to be inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome... The results suggest that this new class of Mtb proteasome inhibitors has the potential to be further developed into novel antitubercular agents for synergistic combination therapies with existing drugs... Supporting information is available on the WWW This is an open-access article, published under the terms and conditions of a Creative Commons License, as stated in the final article. (see article for access details).

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Graphical Abstract: ChemistryOpen 3/2015.

- ChemistryOpen (2015)

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Related In: Results  -  Collection

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View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

ChemistryOPEN is a multidisciplinary, gold-road, open-access, international forum for the publication of Reviews, Full Papers and Communications from all areas of chemistry and related fields... Based in Europe, ChemistryOpen attracts authors and readers from around the world, as open-access publishing becomes more important in all areas of chemistry... The cover picture shows hydrogen bonds in the adenine–thymine (AT) Watson– Crick base pair... Ferric Phosphate Hydroxide Microstructures Affect Their Magnetic Properties Chitosan thin films were developed on polysulfone/TiO2 composite membranes and were characterized by IR spectroscopy, XRD, SEM, contact angle measurement, and water uptake studies... The resulting membranes were used for the reduction of toxic CrVI to CrIII, which can then be adsorbed to the surface... This joint theoretical and experimental study shows that an N-allylmodified 5’ cap found in mRNA can be reacted with tetrazoles in a photoclick reaction... The combination of enzymatic allylation and photoclick chemistry generates a turn-on fluorophore specifically at the 5’ cap found in eukaryotic mRNAs... Revisiting Aromaticity and Chemical Bonding of Fluorinated Benzene Derivatives Here, we analyzed the electron delocalization in fluorinated benzene derivatives (C6H(6¢n)Fn) in terms of the induced magnetic field, nucleus-independent chemical shift (NICS), and ring current strength (RCS)... Fluorination was found to decrease the paratropic ring current through inductive effects and to decrease the diatropic ring current through resonance effects, and the balance between these two effects decreases aromaticity with increased fluorination... Influence of Polarity and Activation Energy in Microwave–Assisted Organic Synthesis (MAOS) This work sought to determine parameters that have decisive roles in microwave-assisted organic reactions (MAOS) and to develop a model, using computational chemistry, to predict the type of reactions that can be improved by using microwave irradiation... Parameters such as polarity, activation energy, and enthalpy were found to be important in the improvement of MAOS... Here we report the design and evaluation of a tumor-specific dendrimer– HDACi... Design and Evaluation of Tumor-Specific Dendrimer Epigenetic Therapeutics 5-styryl-oxathiazol- 2-ones were found to be inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome... The results suggest that this new class of Mtb proteasome inhibitors has the potential to be further developed into novel antitubercular agents for synergistic combination therapies with existing drugs... Supporting information is available on the WWW This is an open-access article, published under the terms and conditions of a Creative Commons License, as stated in the final article. (see article for access details).

No MeSH data available.