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Graphical Abstract: ChemistryOpen 3/2015.

- ChemistryOpen (2015)

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ChemistryOPEN is a multidisciplinary, gold-road, open-access, international forum for the publication of Reviews, Full Papers and Communications from all areas of chemistry and related fields... Based in Europe, ChemistryOpen attracts authors and readers from around the world, as open-access publishing becomes more important in all areas of chemistry... The cover picture shows hydrogen bonds in the adenine–thymine (AT) Watson– Crick base pair... Quantum Chemical Calculations and Experimental Validation of the Photoclick Reaction for Fluorescent Labeling of the 5’ cap of Eukaryotic mRNAs Bioorthogonal click reactions are powerful tools to specifically label biomolecules in living cells... This joint theoretical and experimental study shows that an N-allylmodified 5’ cap found in mRNA can be reacted with tetrazoles in a photoclick reaction... Revisiting Aromaticity and Chemical Bonding of Fluorinated Benzene Derivatives Here, we analyzed the electron delocalization in fluorinated benzene derivatives (C6H(6¢n)Fn) in terms of the induced magnetic field, nucleus-independent chemical shift (NICS), and ring current strength (RCS)... Fluorination was found to decrease the paratropic ring current through inductive effects and to decrease the diatropic ring current through resonance effects, and the balance between these two effects decreases aromaticity with increased fluorination... Influence of Polarity and Activation Energy in Microwave–Assisted Organic Synthesis (MAOS) This work sought to determine parameters that have decisive roles in microwave-assisted organic reactions (MAOS) and to develop a model, using computational chemistry, to predict the type of reactions that can be improved by using microwave irradiation... Parameters such as polarity, activation energy, and enthalpy were found to be important in the improvement of MAOS... Hydrogen bonds play a crucial role in many biochemical processes... We show quantum chemically that neither aromaticity nor π assistance is responsible for the enhanced stability of the H-bonds in adenine–thymine DNA base pairs... The results suggest that this new class of Mtb proteasome inhibitors has the potential to be further developed into novel antitubercular agents for synergistic combination therapies with existing drugs... Supported Sulfonic Acids: Solid Catalysts for Batch and Continuous-Flow Synthetic Processes In this work, supported sulfonic acids were used as effective catalysts for different classes of reactions... They have the advantage of being cheap, safe, and easy to recycle... Supporting information is available on the WWW This is an open-access article, published under the terms and conditions of a Creative Commons License, as stated in the final article. (see article for access details).

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Graphical Abstract: ChemistryOpen 3/2015.

- ChemistryOpen (2015)

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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4522168&req=5

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

ChemistryOPEN is a multidisciplinary, gold-road, open-access, international forum for the publication of Reviews, Full Papers and Communications from all areas of chemistry and related fields... Based in Europe, ChemistryOpen attracts authors and readers from around the world, as open-access publishing becomes more important in all areas of chemistry... The cover picture shows hydrogen bonds in the adenine–thymine (AT) Watson– Crick base pair... Quantum Chemical Calculations and Experimental Validation of the Photoclick Reaction for Fluorescent Labeling of the 5’ cap of Eukaryotic mRNAs Bioorthogonal click reactions are powerful tools to specifically label biomolecules in living cells... This joint theoretical and experimental study shows that an N-allylmodified 5’ cap found in mRNA can be reacted with tetrazoles in a photoclick reaction... Revisiting Aromaticity and Chemical Bonding of Fluorinated Benzene Derivatives Here, we analyzed the electron delocalization in fluorinated benzene derivatives (C6H(6¢n)Fn) in terms of the induced magnetic field, nucleus-independent chemical shift (NICS), and ring current strength (RCS)... Fluorination was found to decrease the paratropic ring current through inductive effects and to decrease the diatropic ring current through resonance effects, and the balance between these two effects decreases aromaticity with increased fluorination... Influence of Polarity and Activation Energy in Microwave–Assisted Organic Synthesis (MAOS) This work sought to determine parameters that have decisive roles in microwave-assisted organic reactions (MAOS) and to develop a model, using computational chemistry, to predict the type of reactions that can be improved by using microwave irradiation... Parameters such as polarity, activation energy, and enthalpy were found to be important in the improvement of MAOS... Hydrogen bonds play a crucial role in many biochemical processes... We show quantum chemically that neither aromaticity nor π assistance is responsible for the enhanced stability of the H-bonds in adenine–thymine DNA base pairs... The results suggest that this new class of Mtb proteasome inhibitors has the potential to be further developed into novel antitubercular agents for synergistic combination therapies with existing drugs... Supported Sulfonic Acids: Solid Catalysts for Batch and Continuous-Flow Synthetic Processes In this work, supported sulfonic acids were used as effective catalysts for different classes of reactions... They have the advantage of being cheap, safe, and easy to recycle... Supporting information is available on the WWW This is an open-access article, published under the terms and conditions of a Creative Commons License, as stated in the final article. (see article for access details).

No MeSH data available.