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Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.

Zhu HT, Bian C, Yuan JC, Liao XJ, Liu W, Zhu G, Feng H, Lin JK - Crit Care (2015)

Bottom Line: After HBO therapy, PbtO2 was significantly increased and LPR and glutamate levels were significantly decreased.Brain edema, neurological deficits and neuronal damage were also ameliorated.Early HBO treatment reduced acute brain injury, perhaps through a mechanism involving the amelioration of the derangement of cerebral oxygenation and metabolism following high-altitude ICH.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Chongqing, 400038, China. hightower26@163.com.

ABSTRACT

Introduction: Intracerebral hemorrhage (ICH) at high altitude is not well understood to date. This study investigates the effects of high altitude on ICH, and examines the acute neuroprotection of hyperbaric oxygen (HBO) therapy against high-altitude ICH.

Methods: Minipigs were placed in a hypobaric chamber for 72 h before the operation. ICH was induced by an infusion of autologous arterial blood (3 ml) into the right basal ganglia. Animals in the high-altitude ICH group received HBO therapy (2.5 ATA for 60 min) 30 min after ICH. Blood gas, blood glucose and brain tissue oxygen partial pressure (PbtO2) were monitored continuously for animals from all groups, as were microdialysis products including glucose, lactate, pyruvate and glutamate in perihematomal tissue from 3 to 12 h post-ICH.

Results: High-altitude ICH animals showed significantly lower PbtO2, higher lactate/pyruvate ratio (LPR) and glutamate levels than low-altitude ICH animals. More severe neurological deficits, brain edema and neuronal damage were also observed in high-altitude ICH. After HBO therapy, PbtO2 was significantly increased and LPR and glutamate levels were significantly decreased. Brain edema, neurological deficits and neuronal damage were also ameliorated.

Conclusions: The data suggested a more serious disturbance of tissue oxygenation and cerebral metabolism in the acute stage after ICH at high altitude. Early HBO treatment reduced acute brain injury, perhaps through a mechanism involving the amelioration of the derangement of cerebral oxygenation and metabolism following high-altitude ICH.

No MeSH data available.


Related in: MedlinePlus

Changes in neurological functioning and brain edema 24 h after ICH. a High-altitude ICH showed more serious neurological function impairments than low-altitude ICH. However, there was no significant difference between HI and HI-HBO animals. b High-altitude ICH also showed more serious brain edema than low-altitude ICH. Moreover, brain water content in HI-HBO animals significantly decreased. *P <0.05
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Fig3: Changes in neurological functioning and brain edema 24 h after ICH. a High-altitude ICH showed more serious neurological function impairments than low-altitude ICH. However, there was no significant difference between HI and HI-HBO animals. b High-altitude ICH also showed more serious brain edema than low-altitude ICH. Moreover, brain water content in HI-HBO animals significantly decreased. *P <0.05

Mentions: There was no significant difference between the PS and HS animals in neurological scores or brain water content. High-altitude ICH showed more serious impairments in neurological functioning than low-altitude ICH (P <0.05). Further, there was significant improvement in neurological deficits after HBO treatment at 24 h post-injury (Fig. 3a). High-altitude ICH also showed higher brain water content than low-altitude ICH (P <0.05). After HBO treatment, brain water content was significantly decreased 24 h after ICH (Fig. 3b).Fig. 3


Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.

Zhu HT, Bian C, Yuan JC, Liao XJ, Liu W, Zhu G, Feng H, Lin JK - Crit Care (2015)

Changes in neurological functioning and brain edema 24 h after ICH. a High-altitude ICH showed more serious neurological function impairments than low-altitude ICH. However, there was no significant difference between HI and HI-HBO animals. b High-altitude ICH also showed more serious brain edema than low-altitude ICH. Moreover, brain water content in HI-HBO animals significantly decreased. *P <0.05
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522125&req=5

Fig3: Changes in neurological functioning and brain edema 24 h after ICH. a High-altitude ICH showed more serious neurological function impairments than low-altitude ICH. However, there was no significant difference between HI and HI-HBO animals. b High-altitude ICH also showed more serious brain edema than low-altitude ICH. Moreover, brain water content in HI-HBO animals significantly decreased. *P <0.05
Mentions: There was no significant difference between the PS and HS animals in neurological scores or brain water content. High-altitude ICH showed more serious impairments in neurological functioning than low-altitude ICH (P <0.05). Further, there was significant improvement in neurological deficits after HBO treatment at 24 h post-injury (Fig. 3a). High-altitude ICH also showed higher brain water content than low-altitude ICH (P <0.05). After HBO treatment, brain water content was significantly decreased 24 h after ICH (Fig. 3b).Fig. 3

Bottom Line: After HBO therapy, PbtO2 was significantly increased and LPR and glutamate levels were significantly decreased.Brain edema, neurological deficits and neuronal damage were also ameliorated.Early HBO treatment reduced acute brain injury, perhaps through a mechanism involving the amelioration of the derangement of cerebral oxygenation and metabolism following high-altitude ICH.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Chongqing, 400038, China. hightower26@163.com.

ABSTRACT

Introduction: Intracerebral hemorrhage (ICH) at high altitude is not well understood to date. This study investigates the effects of high altitude on ICH, and examines the acute neuroprotection of hyperbaric oxygen (HBO) therapy against high-altitude ICH.

Methods: Minipigs were placed in a hypobaric chamber for 72 h before the operation. ICH was induced by an infusion of autologous arterial blood (3 ml) into the right basal ganglia. Animals in the high-altitude ICH group received HBO therapy (2.5 ATA for 60 min) 30 min after ICH. Blood gas, blood glucose and brain tissue oxygen partial pressure (PbtO2) were monitored continuously for animals from all groups, as were microdialysis products including glucose, lactate, pyruvate and glutamate in perihematomal tissue from 3 to 12 h post-ICH.

Results: High-altitude ICH animals showed significantly lower PbtO2, higher lactate/pyruvate ratio (LPR) and glutamate levels than low-altitude ICH animals. More severe neurological deficits, brain edema and neuronal damage were also observed in high-altitude ICH. After HBO therapy, PbtO2 was significantly increased and LPR and glutamate levels were significantly decreased. Brain edema, neurological deficits and neuronal damage were also ameliorated.

Conclusions: The data suggested a more serious disturbance of tissue oxygenation and cerebral metabolism in the acute stage after ICH at high altitude. Early HBO treatment reduced acute brain injury, perhaps through a mechanism involving the amelioration of the derangement of cerebral oxygenation and metabolism following high-altitude ICH.

No MeSH data available.


Related in: MedlinePlus