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Urinary adiponectin and albuminuria in non-diabetic hypertensive patients: an analysis of the ESPECIAL trial.

Han SS, Bae E, Ahn SY, Kim S, Park JH, Shin SJ, Lee SH, Choi BS, Chin HJ, Lim CS, Kim S, Kim DK - BMC Nephrol (2015)

Bottom Line: After adjusting for several covariates, the adiponectin level was associated with the albuminuria level (β = 0.446).In contrast, among all subjects, the frequency of the normoalbuminuria achievement (< 30 mg/day) at 16 weeks was higher in the 1(st) tertile than in the 3(rd) tertile (odds ratio = 13.0).Urinary adiponectin may be a useful biomarker for albuminuria or its response after treatment in non-diabetic hypertensive patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul, 110-744, South Korea. hansway80@gmail.com.

ABSTRACT

Background: Although adiponectin levels have been reported to be correlated with albuminuria, this issue remains unresolved in non-diabetic hypertensive subjects, particularly when urinary adiponectin is considered.

Methods: Urinary adiponectin levels were examined using an enzyme-linked immunosorbent assay in 229 participants. who used olmesartan as a hypertensive agent. Their albuminuria levels were measured for 16 weeks after randomization and initiation of conventional or intensive diet education. Linear or logistic regression models were applied, as appropriate, to explore the relationship with albuminuria itself or its response after the intervention.

Results: Urinary adiponectin levels were positively related to baseline albuminuria level (r = 0.529). After adjusting for several covariates, the adiponectin level was associated with the albuminuria level (β = 0.446). Among the 159 subjects with baseline macroalbuminuria, the risk of consistent macroalbuminuria (> 300 mg/day) at 16 weeks was higher in the 3(rd) tertile of adiponectin than in the 1(st) tertile (odds ratio = 6.9), despite diet education. In contrast, among all subjects, the frequency of the normoalbuminuria achievement (< 30 mg/day) at 16 weeks was higher in the 1(st) tertile than in the 3(rd) tertile (odds ratio = 13.0).

Conclusions: Urinary adiponectin may be a useful biomarker for albuminuria or its response after treatment in non-diabetic hypertensive patients.

No MeSH data available.


Related in: MedlinePlus

Fitted curve of the achievement of normoalbuminuria at 16 weeks, according to the urinary adiponectin level
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Fig3: Fitted curve of the achievement of normoalbuminuria at 16 weeks, according to the urinary adiponectin level

Mentions: Additionally, we examined the predictability of normoalbuminuria after treatment. At 8 and 16 weeks, albuminuria disappeared in 4.8 % and 9.2 % of participants, respectively. Figure 3 shows the inverse relationship between the urinary adiponectin level and the likelihood of subsequent normoalbuminuria. We calculated the unadjusted and adjusted ORs of the 16-week outcome after assigning a reference to the 3rd tertile (Table 4). As a result, the subjects with low adiponectin levels achieved normoalbuminuria more frequently than did the subjects with high adiponectin levels. For the 8-week outcome, neither a non-linear relationship nor ORs could be calculated because of the low number of cases attaining normoalbuminuria at 8 weeks, and there were no such cases in the 3rd tertile group.Fig. 3


Urinary adiponectin and albuminuria in non-diabetic hypertensive patients: an analysis of the ESPECIAL trial.

Han SS, Bae E, Ahn SY, Kim S, Park JH, Shin SJ, Lee SH, Choi BS, Chin HJ, Lim CS, Kim S, Kim DK - BMC Nephrol (2015)

Fitted curve of the achievement of normoalbuminuria at 16 weeks, according to the urinary adiponectin level
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522110&req=5

Fig3: Fitted curve of the achievement of normoalbuminuria at 16 weeks, according to the urinary adiponectin level
Mentions: Additionally, we examined the predictability of normoalbuminuria after treatment. At 8 and 16 weeks, albuminuria disappeared in 4.8 % and 9.2 % of participants, respectively. Figure 3 shows the inverse relationship between the urinary adiponectin level and the likelihood of subsequent normoalbuminuria. We calculated the unadjusted and adjusted ORs of the 16-week outcome after assigning a reference to the 3rd tertile (Table 4). As a result, the subjects with low adiponectin levels achieved normoalbuminuria more frequently than did the subjects with high adiponectin levels. For the 8-week outcome, neither a non-linear relationship nor ORs could be calculated because of the low number of cases attaining normoalbuminuria at 8 weeks, and there were no such cases in the 3rd tertile group.Fig. 3

Bottom Line: After adjusting for several covariates, the adiponectin level was associated with the albuminuria level (β = 0.446).In contrast, among all subjects, the frequency of the normoalbuminuria achievement (< 30 mg/day) at 16 weeks was higher in the 1(st) tertile than in the 3(rd) tertile (odds ratio = 13.0).Urinary adiponectin may be a useful biomarker for albuminuria or its response after treatment in non-diabetic hypertensive patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul, 110-744, South Korea. hansway80@gmail.com.

ABSTRACT

Background: Although adiponectin levels have been reported to be correlated with albuminuria, this issue remains unresolved in non-diabetic hypertensive subjects, particularly when urinary adiponectin is considered.

Methods: Urinary adiponectin levels were examined using an enzyme-linked immunosorbent assay in 229 participants. who used olmesartan as a hypertensive agent. Their albuminuria levels were measured for 16 weeks after randomization and initiation of conventional or intensive diet education. Linear or logistic regression models were applied, as appropriate, to explore the relationship with albuminuria itself or its response after the intervention.

Results: Urinary adiponectin levels were positively related to baseline albuminuria level (r = 0.529). After adjusting for several covariates, the adiponectin level was associated with the albuminuria level (β = 0.446). Among the 159 subjects with baseline macroalbuminuria, the risk of consistent macroalbuminuria (> 300 mg/day) at 16 weeks was higher in the 3(rd) tertile of adiponectin than in the 1(st) tertile (odds ratio = 6.9), despite diet education. In contrast, among all subjects, the frequency of the normoalbuminuria achievement (< 30 mg/day) at 16 weeks was higher in the 1(st) tertile than in the 3(rd) tertile (odds ratio = 13.0).

Conclusions: Urinary adiponectin may be a useful biomarker for albuminuria or its response after treatment in non-diabetic hypertensive patients.

No MeSH data available.


Related in: MedlinePlus