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CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer.

Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y - World J Surg Oncol (2015)

Bottom Line: In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications.In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications.Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. tmsha@infoseek.jp.

ABSTRACT

Background: Esophagectomy is one of the most invasive surgical treatments for digestive tract cancer, and the blood levels of inflammatory cytokines such as interleukin-1, interleukin-6, and interleukin-8 are increased for several hours after surgery or in patients experiencing postoperative complications. CXCR2, an interleukin-8 receptor, is reportedly expressed in several carcinomas, and interleukin-8 signaling promotes cancer cell proliferation. The impact of postoperative complications following esophagectomy on long-term survival is controversial. In this study, we demonstrate the significance of CXCR2 expression and validate the effects of CXCR2 expression and postoperative complications on long-term prognosis of esophageal squamous cell carcinoma using resected specimens.

Methods: Eighty-two specimens were sectioned from archived, paraffin-embedded tumor tissues obtained from patients with esophageal squamous cell carcinoma who underwent esophagectomy and extended lymphadenectomy for complete resection of cancer in our institute between 1997 and 2002. Immunohistochemistry was performed using a polyclonal antibody to CXCR2, and the correlation of stainability with clinicopathological factors and long-term survival was examined.

Results: CXCR2 was expressed in 33 of 82 (40.2 %) specimens. In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications. In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications. CXCR2 positivity combined with postoperative complications was an independent risk factor for subsequent tumor recurrence, showing the highest hazard ratio.

Conclusions: Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed.

Trial registration: This study was approved by Keio University School of Medicine Ethics Committee with a trial registration number of 2011-241.

No MeSH data available.


Related in: MedlinePlus

a Recurrence-free survival and b overall survival after esophagectomy between the CXCR2(+)/complication(+) group and the others
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Fig4: a Recurrence-free survival and b overall survival after esophagectomy between the CXCR2(+)/complication(+) group and the others

Mentions: Therefore, we divided these 82 patients into two groups: those with CXCR2-positive tumors who developed postoperative complication(s) [CXCR2(+)/complication(+) group; n = 17 (20.7 %)] and all other patients [n = 65 (79.3 %)]. RFS for the CXCR2(+)/complication(+) group was significantly poorer than that for the other group (p = 0.0009; Fig. 4a). The same result was obtained for OS (p = 0.0019; Fig. 4b).Fig. 4


CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer.

Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y - World J Surg Oncol (2015)

a Recurrence-free survival and b overall survival after esophagectomy between the CXCR2(+)/complication(+) group and the others
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522106&req=5

Fig4: a Recurrence-free survival and b overall survival after esophagectomy between the CXCR2(+)/complication(+) group and the others
Mentions: Therefore, we divided these 82 patients into two groups: those with CXCR2-positive tumors who developed postoperative complication(s) [CXCR2(+)/complication(+) group; n = 17 (20.7 %)] and all other patients [n = 65 (79.3 %)]. RFS for the CXCR2(+)/complication(+) group was significantly poorer than that for the other group (p = 0.0009; Fig. 4a). The same result was obtained for OS (p = 0.0019; Fig. 4b).Fig. 4

Bottom Line: In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications.In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications.Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. tmsha@infoseek.jp.

ABSTRACT

Background: Esophagectomy is one of the most invasive surgical treatments for digestive tract cancer, and the blood levels of inflammatory cytokines such as interleukin-1, interleukin-6, and interleukin-8 are increased for several hours after surgery or in patients experiencing postoperative complications. CXCR2, an interleukin-8 receptor, is reportedly expressed in several carcinomas, and interleukin-8 signaling promotes cancer cell proliferation. The impact of postoperative complications following esophagectomy on long-term survival is controversial. In this study, we demonstrate the significance of CXCR2 expression and validate the effects of CXCR2 expression and postoperative complications on long-term prognosis of esophageal squamous cell carcinoma using resected specimens.

Methods: Eighty-two specimens were sectioned from archived, paraffin-embedded tumor tissues obtained from patients with esophageal squamous cell carcinoma who underwent esophagectomy and extended lymphadenectomy for complete resection of cancer in our institute between 1997 and 2002. Immunohistochemistry was performed using a polyclonal antibody to CXCR2, and the correlation of stainability with clinicopathological factors and long-term survival was examined.

Results: CXCR2 was expressed in 33 of 82 (40.2 %) specimens. In the CXCR2-positive group, the recurrence-free survival and overall survival rates of patients who developed postoperative complications were both significantly lower than those for patients who did not develop any complications. In contrast, in the CXCR2-negative group, there was no significant difference in long-term prognosis between patients with and without complications. CXCR2 positivity combined with postoperative complications was an independent risk factor for subsequent tumor recurrence, showing the highest hazard ratio.

Conclusions: Our results suggest that the patients with CXCR2-positive esophageal cancer who develop postoperative complications have a poor prognosis and should be carefully followed.

Trial registration: This study was approved by Keio University School of Medicine Ethics Committee with a trial registration number of 2011-241.

No MeSH data available.


Related in: MedlinePlus