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Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis.

Shen L, Ji HF - Nutr J (2015)

Bottom Line: Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L.Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects.There is no evidence for significant heterogeneity among the included studies.

View Article: PubMed Central - PubMed

Affiliation: Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, 255049, P. R. China.

ABSTRACT

Background: In recent years, the associations between vitamin D status and Alzheimer's disease (AD) and dementia have gained increasing interests. The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia.

Methods: A literature search conducted until February 2015 identified 10 study populations, which were included in the meta-analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated with a random-effect model using Stata software package.

Results: Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects. There is no evidence for significant heterogeneity among the included studies.

Conclusion: Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia. More studies are needed to further confirm the associations and to evaluate the beneficial effects of vitamin D supplementation in preventing AD and dementia.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the included studies investigating risk of developing AD in vitamin D deficient subjects. The size of each square is proportional to the study’s weight
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Fig2: Forest plot of the included studies investigating risk of developing AD in vitamin D deficient subjects. The size of each square is proportional to the study’s weight

Mentions: Five study populations from three studies were included in the meta-analysis of the association between vitamin D deficiency and risk of developing AD [9, 10, 12]. Main characteristics of the included studies were provided in Table 1. Forest plot of the included studies investigating risk of AD in vitamin D deficient subjects was shown in Fig. 2. Results of the prospective cohort studies showed that vitamin D deficiency was associated with increased risk of AD occurrence compared to the subjects with 25(OH)D level > 50 nmol/L, overall OR = 1.21, 95 % CI 1.01–1.40. The I2 value was 0.0 %, which suggested that there was no evidence for significant heterogeneity. The inclusion of one cross-sectional study negligibly affected the results (Fig. 2).Table 1


Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis.

Shen L, Ji HF - Nutr J (2015)

Forest plot of the included studies investigating risk of developing AD in vitamin D deficient subjects. The size of each square is proportional to the study’s weight
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522102&req=5

Fig2: Forest plot of the included studies investigating risk of developing AD in vitamin D deficient subjects. The size of each square is proportional to the study’s weight
Mentions: Five study populations from three studies were included in the meta-analysis of the association between vitamin D deficiency and risk of developing AD [9, 10, 12]. Main characteristics of the included studies were provided in Table 1. Forest plot of the included studies investigating risk of AD in vitamin D deficient subjects was shown in Fig. 2. Results of the prospective cohort studies showed that vitamin D deficiency was associated with increased risk of AD occurrence compared to the subjects with 25(OH)D level > 50 nmol/L, overall OR = 1.21, 95 % CI 1.01–1.40. The I2 value was 0.0 %, which suggested that there was no evidence for significant heterogeneity. The inclusion of one cross-sectional study negligibly affected the results (Fig. 2).Table 1

Bottom Line: Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L.Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects.There is no evidence for significant heterogeneity among the included studies.

View Article: PubMed Central - PubMed

Affiliation: Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, 255049, P. R. China.

ABSTRACT

Background: In recent years, the associations between vitamin D status and Alzheimer's disease (AD) and dementia have gained increasing interests. The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia.

Methods: A literature search conducted until February 2015 identified 10 study populations, which were included in the meta-analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated with a random-effect model using Stata software package.

Results: Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects. There is no evidence for significant heterogeneity among the included studies.

Conclusion: Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia. More studies are needed to further confirm the associations and to evaluate the beneficial effects of vitamin D supplementation in preventing AD and dementia.

No MeSH data available.


Related in: MedlinePlus