Limits...
A prospective, longitudinal, observational cohort study examining how glaucoma affects quality of life and visually-related function over 4 years: design and methodology.

Waisbourd M, Parker S, Ekici F, Martinez P, Murphy R, Scully K, Wizov SS, Hark LA, Spaeth GL - BMC Ophthalmol (2015)

Bottom Line: Patients between the ages of 21-85 years with a minimum 2-year diagnosis of primary open-angle glaucoma, chronic primary angle-closure glaucoma or pseudoexfoliation glaucoma were included.Each patient visited Wills Eye Hospital for a baseline visit.Follow-up is planned for a minimum of 4 years, with annual visits.

View Article: PubMed Central - PubMed

Affiliation: Glaucoma Research Center, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA, 19107, USA. MWaisbourd@willseye.org.

ABSTRACT

Background: The aim of this study is to summarize the design and methodology of a prospective, longitudinal, observational cohort study to investigate how glaucoma affects patients' quality of life and visually-related function over a 4-year period.

Methods/design: One hundred sixty-one (161) subjects were enrolled in this ongoing study. Patients between the ages of 21-85 years with a minimum 2-year diagnosis of primary open-angle glaucoma, chronic primary angle-closure glaucoma or pseudoexfoliation glaucoma were included. Each patient visited Wills Eye Hospital for a baseline visit. Follow-up is planned for a minimum of 4 years, with annual visits. Each visit includes (1) Clinical evaluation: a slit lamp examination, fundoscopy, intraocular pressure measurement, visual field examination, spectral domain optical coherence tomography, Pelli-Robson Contrast Sensitivity test and the Spaeth-Richman Contrast Sensitivity test; (2) a performance based measure: the Compressed Assessment of Ability Related to Vision; and (3) Subjective measures of vision-related quality of life (the National Eye Institute Visual Functioning Questionnaire 25 and the Modified Glaucoma Symptom Scale).

Discussion: The results of this ongoing, prospective, longitudinal study are expected to shed light on the relationships between clinical measures, performance-based measures and subjective measures of well-being, in order to assess changes in the quality of life and the ability to function of patients with glaucoma over time.

Show MeSH

Related in: MedlinePlus

Spaeth Richman Contrast Sensitivity Test (SPARCS). Two parallel horizontal lines and 2 parallel vertical lines intersect to create 9 boxes, including a 5 cm rectangle in the center. Note the darkened square waves in the right upper quadrant. During a “set”, darkened square waves randomly appear briefly in 1 of the 5 tested areas while the other 4 areas remain the same shade as the background. Contrast between the bars and background decreases by 50 % after each cycle
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4522094&req=5

Fig1: Spaeth Richman Contrast Sensitivity Test (SPARCS). Two parallel horizontal lines and 2 parallel vertical lines intersect to create 9 boxes, including a 5 cm rectangle in the center. Note the darkened square waves in the right upper quadrant. During a “set”, darkened square waves randomly appear briefly in 1 of the 5 tested areas while the other 4 areas remain the same shade as the background. Contrast between the bars and background decreases by 50 % after each cycle

Mentions: The SPARCS test is a new method of measuring contrast sensitivity. It is performed on any standard computer with Internet access [26]. In this study, the SPARCS test was administered on the same computer, with standardized lighting conditions. SPARCS tests contrast sensitivity in 5 different areas of the VF: centrally and in 4 peripheral quadrants (Fig. 1). It does not require the patient to recognize objects or letters, which reduces the confounding effects of literacy, culture, and intelligence as well as the effects of macular function and VA. Correct and incorrect responses are recorded until the contrast threshold is determined in each of the 5 testing areas.Fig. 1


A prospective, longitudinal, observational cohort study examining how glaucoma affects quality of life and visually-related function over 4 years: design and methodology.

Waisbourd M, Parker S, Ekici F, Martinez P, Murphy R, Scully K, Wizov SS, Hark LA, Spaeth GL - BMC Ophthalmol (2015)

Spaeth Richman Contrast Sensitivity Test (SPARCS). Two parallel horizontal lines and 2 parallel vertical lines intersect to create 9 boxes, including a 5 cm rectangle in the center. Note the darkened square waves in the right upper quadrant. During a “set”, darkened square waves randomly appear briefly in 1 of the 5 tested areas while the other 4 areas remain the same shade as the background. Contrast between the bars and background decreases by 50 % after each cycle
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522094&req=5

Fig1: Spaeth Richman Contrast Sensitivity Test (SPARCS). Two parallel horizontal lines and 2 parallel vertical lines intersect to create 9 boxes, including a 5 cm rectangle in the center. Note the darkened square waves in the right upper quadrant. During a “set”, darkened square waves randomly appear briefly in 1 of the 5 tested areas while the other 4 areas remain the same shade as the background. Contrast between the bars and background decreases by 50 % after each cycle
Mentions: The SPARCS test is a new method of measuring contrast sensitivity. It is performed on any standard computer with Internet access [26]. In this study, the SPARCS test was administered on the same computer, with standardized lighting conditions. SPARCS tests contrast sensitivity in 5 different areas of the VF: centrally and in 4 peripheral quadrants (Fig. 1). It does not require the patient to recognize objects or letters, which reduces the confounding effects of literacy, culture, and intelligence as well as the effects of macular function and VA. Correct and incorrect responses are recorded until the contrast threshold is determined in each of the 5 testing areas.Fig. 1

Bottom Line: Patients between the ages of 21-85 years with a minimum 2-year diagnosis of primary open-angle glaucoma, chronic primary angle-closure glaucoma or pseudoexfoliation glaucoma were included.Each patient visited Wills Eye Hospital for a baseline visit.Follow-up is planned for a minimum of 4 years, with annual visits.

View Article: PubMed Central - PubMed

Affiliation: Glaucoma Research Center, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA, 19107, USA. MWaisbourd@willseye.org.

ABSTRACT

Background: The aim of this study is to summarize the design and methodology of a prospective, longitudinal, observational cohort study to investigate how glaucoma affects patients' quality of life and visually-related function over a 4-year period.

Methods/design: One hundred sixty-one (161) subjects were enrolled in this ongoing study. Patients between the ages of 21-85 years with a minimum 2-year diagnosis of primary open-angle glaucoma, chronic primary angle-closure glaucoma or pseudoexfoliation glaucoma were included. Each patient visited Wills Eye Hospital for a baseline visit. Follow-up is planned for a minimum of 4 years, with annual visits. Each visit includes (1) Clinical evaluation: a slit lamp examination, fundoscopy, intraocular pressure measurement, visual field examination, spectral domain optical coherence tomography, Pelli-Robson Contrast Sensitivity test and the Spaeth-Richman Contrast Sensitivity test; (2) a performance based measure: the Compressed Assessment of Ability Related to Vision; and (3) Subjective measures of vision-related quality of life (the National Eye Institute Visual Functioning Questionnaire 25 and the Modified Glaucoma Symptom Scale).

Discussion: The results of this ongoing, prospective, longitudinal study are expected to shed light on the relationships between clinical measures, performance-based measures and subjective measures of well-being, in order to assess changes in the quality of life and the ability to function of patients with glaucoma over time.

Show MeSH
Related in: MedlinePlus