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Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer.

Zhou L, Yu L, Wu S, Feng Z, Song W, Gong X - World J Surg Oncol (2015)

Bottom Line: Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM.In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.Tumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. zhou_lei03@163.com.

ABSTRACT

Background: KAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies. We aimed to investigate the KAI1 and marker of EMT expression and correlation with lymph node metastasis (LNM) and explore their prognostic impact in non-small cell lung cancer (NSCLC).

Methods: Tumor tissue specimens from 312 resected patients with stage I-IIIA NSCLC were obtained. Immunohistochemistry was used to assess the expression of the molecular markers KAI1, E-cadherin (E-cad), vimentin, CD34, and D2-40.

Results: There were 153 N0 and 159 N+ patients. Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM. In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.

Conclusions: Tumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM. Thus, the detection of KAI1, expression of markers of EMT, and the scores of MVD may be used as a potential indicator of NSCLC prognosis.

No MeSH data available.


Related in: MedlinePlus

Representative results of KAI1 and vimentin and E-cadherin protein in NSCLC. a Moderately differentiated NSCLC, H&E staining. b KAI1 protein predominantly localized in the membrane and cytoplasm in well-differentiated squamous carcinoma. c NSCLC cells did not express a detectable level of E-cadherin protein. d Vimentin protein localized in the cytoplasm and membrane in NSCLC cells (a, c, and d are serial sections)
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Fig1: Representative results of KAI1 and vimentin and E-cadherin protein in NSCLC. a Moderately differentiated NSCLC, H&E staining. b KAI1 protein predominantly localized in the membrane and cytoplasm in well-differentiated squamous carcinoma. c NSCLC cells did not express a detectable level of E-cadherin protein. d Vimentin protein localized in the cytoplasm and membrane in NSCLC cells (a, c, and d are serial sections)

Mentions: In NSCLC (Fig. 1b), the positive expression of KAI1 was 34.0 % (106/312) (Fig. 1a), the positive expression of E-cad was 39.7 % (124/312) (Fig. 1c), and the positive expression of vimentin was 42.3 %(132/312) (Fig. 1d). There was a significant difference between the expression of KAI1, E-cad, and vimentin and grades of tumors (P < 0.001) and TNM stage (P < 0.001) (Table 1).Fig. 1


Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer.

Zhou L, Yu L, Wu S, Feng Z, Song W, Gong X - World J Surg Oncol (2015)

Representative results of KAI1 and vimentin and E-cadherin protein in NSCLC. a Moderately differentiated NSCLC, H&E staining. b KAI1 protein predominantly localized in the membrane and cytoplasm in well-differentiated squamous carcinoma. c NSCLC cells did not express a detectable level of E-cadherin protein. d Vimentin protein localized in the cytoplasm and membrane in NSCLC cells (a, c, and d are serial sections)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522085&req=5

Fig1: Representative results of KAI1 and vimentin and E-cadherin protein in NSCLC. a Moderately differentiated NSCLC, H&E staining. b KAI1 protein predominantly localized in the membrane and cytoplasm in well-differentiated squamous carcinoma. c NSCLC cells did not express a detectable level of E-cadherin protein. d Vimentin protein localized in the cytoplasm and membrane in NSCLC cells (a, c, and d are serial sections)
Mentions: In NSCLC (Fig. 1b), the positive expression of KAI1 was 34.0 % (106/312) (Fig. 1a), the positive expression of E-cad was 39.7 % (124/312) (Fig. 1c), and the positive expression of vimentin was 42.3 %(132/312) (Fig. 1d). There was a significant difference between the expression of KAI1, E-cad, and vimentin and grades of tumors (P < 0.001) and TNM stage (P < 0.001) (Table 1).Fig. 1

Bottom Line: Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM.In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.Tumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, the First Hospital Affiliated of Bengbu Medical College, Bengbu Medical College, No. 287 Changhuai Ave, Longzihu, Bengbu, Anhui Province, 233003, China. zhou_lei03@163.com.

ABSTRACT

Background: KAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies. We aimed to investigate the KAI1 and marker of EMT expression and correlation with lymph node metastasis (LNM) and explore their prognostic impact in non-small cell lung cancer (NSCLC).

Methods: Tumor tissue specimens from 312 resected patients with stage I-IIIA NSCLC were obtained. Immunohistochemistry was used to assess the expression of the molecular markers KAI1, E-cadherin (E-cad), vimentin, CD34, and D2-40.

Results: There were 153 N0 and 159 N+ patients. Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM. In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.

Conclusions: Tumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM. Thus, the detection of KAI1, expression of markers of EMT, and the scores of MVD may be used as a potential indicator of NSCLC prognosis.

No MeSH data available.


Related in: MedlinePlus