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Innovation in catheter design for intra-arterial liver cancer treatments results in favorable particle-fluid dynamics.

van den Hoven AF, Lam MG, Jernigan S, van den Bosch MA, Buckner GD - J. Exp. Clin. Cancer Res. (2015)

Bottom Line: Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrations.Quantitative analyses confirmed a significantly more homogeneous distribution with the ARC; the mean DHD was 40.85 % (IQR 22.76 %) for the SMC and 15.54 % (IQR 6.46 %) for the ARC (p = 0.047).Catheter type has a significant impact on microsphere administrations in an in-vitro hepatic arterial model.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Room E.01.132, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. a.f.vandenhoven@umcutrecht.nl.

ABSTRACT

Background: Liver tumors are increasingly treated with radioembolization. Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrations.

Materials and methods: A total of 7 experiments were performed in a bench-top model of the hepatic arterial vasculature with recreated hemodynamics. Fluorescent microspheres and clinically used holmium microspheres were administered with a standard microcatheter (SMC) and an anti-reflux catheter (ARC) positioned at the same level along the longitudinal vessel axis. Catheter-related particle flow dynamics were analyzed by reviewing video recordings of UV-light illuminated fluorescent microsphere administrations. Downstream branch distribution was analyzed by quantification of collected microspheres in separate filters for two first-order branches. Mean deviation from a perfectly homogenous distribution (DHD) was used to compare the distribution homogeneity between catheter types.

Results: The SMC administrations demonstrated a random off-centered catheter position (in 71 % of experiments), and a laminar particle flow pattern with an inhomogeneous downstream branch distribution, dependent on catheter position and injection force. The ARC administrations demonstrated a fixed centro-luminal catheter position, and a turbulent particle flow pattern with a more consistent and homogenous downstream branch distribution. Quantitative analyses confirmed a significantly more homogeneous distribution with the ARC; the mean DHD was 40.85 % (IQR 22.76 %) for the SMC and 15.54 % (IQR 6.46 %) for the ARC (p = 0.047).

Conclusion: Catheter type has a significant impact on microsphere administrations in an in-vitro hepatic arterial model. A within-patient randomized controlled trial has been initiated to investigate clinical catheter-related effects during radioembolization treatment.

No MeSH data available.


Related in: MedlinePlus

Catheter-related particle flow-dynamics. Composite figure of the fluorescent microsphere administrations with the SMC (a) and ARC (b) Images of fluorescent microsphere administrations were created by overlaying frames from a representative part of the experiment 3 video (Additional file 1: Movie S1), to show the typical catheter-related particle flow pattern. The background of images (a) and (b) was edited in Adobe Photoshop to emphasize an area of interest. a Off-centered SMC position, laminar outflow pattern and absence of microsphere flow towards the LHA. b Centro-luminal ARC position, turbulent outflow pattern (note the eddy current adjacent to the ARC tip) and more homogenous microsphere distribution over the LHA and RHA
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Fig4: Catheter-related particle flow-dynamics. Composite figure of the fluorescent microsphere administrations with the SMC (a) and ARC (b) Images of fluorescent microsphere administrations were created by overlaying frames from a representative part of the experiment 3 video (Additional file 1: Movie S1), to show the typical catheter-related particle flow pattern. The background of images (a) and (b) was edited in Adobe Photoshop to emphasize an area of interest. a Off-centered SMC position, laminar outflow pattern and absence of microsphere flow towards the LHA. b Centro-luminal ARC position, turbulent outflow pattern (note the eddy current adjacent to the ARC tip) and more homogenous microsphere distribution over the LHA and RHA

Mentions: Catheter positions during fluorescent microsphere administrations. Photographs of the catheter positions in the geometry of the recreated hepatic arterial model, corresponding to the fluorescent microsphere administrations in Fig. 4. a Note the SMC tip deviation towards the right side. b Fixed centro-luminal position of the ARC. Abbreviations: LHA = left hepatic artery; RHA = right hepatic artery; PHA = proper hepatic artery. NB: the model is oriented up-side down


Innovation in catheter design for intra-arterial liver cancer treatments results in favorable particle-fluid dynamics.

van den Hoven AF, Lam MG, Jernigan S, van den Bosch MA, Buckner GD - J. Exp. Clin. Cancer Res. (2015)

Catheter-related particle flow-dynamics. Composite figure of the fluorescent microsphere administrations with the SMC (a) and ARC (b) Images of fluorescent microsphere administrations were created by overlaying frames from a representative part of the experiment 3 video (Additional file 1: Movie S1), to show the typical catheter-related particle flow pattern. The background of images (a) and (b) was edited in Adobe Photoshop to emphasize an area of interest. a Off-centered SMC position, laminar outflow pattern and absence of microsphere flow towards the LHA. b Centro-luminal ARC position, turbulent outflow pattern (note the eddy current adjacent to the ARC tip) and more homogenous microsphere distribution over the LHA and RHA
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522078&req=5

Fig4: Catheter-related particle flow-dynamics. Composite figure of the fluorescent microsphere administrations with the SMC (a) and ARC (b) Images of fluorescent microsphere administrations were created by overlaying frames from a representative part of the experiment 3 video (Additional file 1: Movie S1), to show the typical catheter-related particle flow pattern. The background of images (a) and (b) was edited in Adobe Photoshop to emphasize an area of interest. a Off-centered SMC position, laminar outflow pattern and absence of microsphere flow towards the LHA. b Centro-luminal ARC position, turbulent outflow pattern (note the eddy current adjacent to the ARC tip) and more homogenous microsphere distribution over the LHA and RHA
Mentions: Catheter positions during fluorescent microsphere administrations. Photographs of the catheter positions in the geometry of the recreated hepatic arterial model, corresponding to the fluorescent microsphere administrations in Fig. 4. a Note the SMC tip deviation towards the right side. b Fixed centro-luminal position of the ARC. Abbreviations: LHA = left hepatic artery; RHA = right hepatic artery; PHA = proper hepatic artery. NB: the model is oriented up-side down

Bottom Line: Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrations.Quantitative analyses confirmed a significantly more homogeneous distribution with the ARC; the mean DHD was 40.85 % (IQR 22.76 %) for the SMC and 15.54 % (IQR 6.46 %) for the ARC (p = 0.047).Catheter type has a significant impact on microsphere administrations in an in-vitro hepatic arterial model.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Room E.01.132, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. a.f.vandenhoven@umcutrecht.nl.

ABSTRACT

Background: Liver tumors are increasingly treated with radioembolization. Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrations.

Materials and methods: A total of 7 experiments were performed in a bench-top model of the hepatic arterial vasculature with recreated hemodynamics. Fluorescent microspheres and clinically used holmium microspheres were administered with a standard microcatheter (SMC) and an anti-reflux catheter (ARC) positioned at the same level along the longitudinal vessel axis. Catheter-related particle flow dynamics were analyzed by reviewing video recordings of UV-light illuminated fluorescent microsphere administrations. Downstream branch distribution was analyzed by quantification of collected microspheres in separate filters for two first-order branches. Mean deviation from a perfectly homogenous distribution (DHD) was used to compare the distribution homogeneity between catheter types.

Results: The SMC administrations demonstrated a random off-centered catheter position (in 71 % of experiments), and a laminar particle flow pattern with an inhomogeneous downstream branch distribution, dependent on catheter position and injection force. The ARC administrations demonstrated a fixed centro-luminal catheter position, and a turbulent particle flow pattern with a more consistent and homogenous downstream branch distribution. Quantitative analyses confirmed a significantly more homogeneous distribution with the ARC; the mean DHD was 40.85 % (IQR 22.76 %) for the SMC and 15.54 % (IQR 6.46 %) for the ARC (p = 0.047).

Conclusion: Catheter type has a significant impact on microsphere administrations in an in-vitro hepatic arterial model. A within-patient randomized controlled trial has been initiated to investigate clinical catheter-related effects during radioembolization treatment.

No MeSH data available.


Related in: MedlinePlus