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Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial.

Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T - BMC Dermatol. (2015)

Bottom Line: We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation.In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.Maternal probiotic ingestion alone may be sufficient for long term reduction in the cumulative incidence of AD, but not other allergy related diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Postboks 8905, MTFS, 7491, Trondheim, Norway. melanie.simpson@ntnu.no.

ABSTRACT

Background: Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.

Methods: Four hundred and fifteen pregnant women were randomised to receive probiotic or placebo milk in a double-blinded trial from 36 week gestation until 3 months postpartum. Probiotic milk contained Lactobacillus rhamnosos GG, L. acidophilus La-5 and Bifidobacterium animalis subsp. lactis Bb-12. At 6 years, children were re-assessed for AD, atopic sensitisation, asthma and allergic rhinoconjunctivitis (ARC).

Results: At 6 years, 81 and 82 children were assessed for AD in the probiotic and placebo groups, respectively. In a multiple imputation analysis, there was as trend towards a lower cumulative incidence of AD in the probiotic group compared to the placebo group (OR 0.64, 95 % CI 0.39-1.07, p = 0.086; NNT = 10). This finding was statistically significantly in the complete case analysis (OR 0.48, 95 % CI 0.25-0.92, p = 0.027, NNT = 6). The prevalence of asthma and atopic sensitisation, and the cumulative incidence of ARC were not significantly affected by the probiotic regime at 6 years of age.

Conclusions: Maternal probiotic ingestion alone may be sufficient for long term reduction in the cumulative incidence of AD, but not other allergy related diseases.

Trial registration: ClinicalTrials.gov identifier: NCT00159523.

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Related in: MedlinePlus

Participant flow diagram. The exact number of women who were invited and or assessed for eligibility is not available. aSeveral children were lost to both questionnaire and examination follow-up as displayed at the bottom of this box. bNumber of participants who moved from the Trondheim municipality was estimated from public address catalogues
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Fig1: Participant flow diagram. The exact number of women who were invited and or assessed for eligibility is not available. aSeveral children were lost to both questionnaire and examination follow-up as displayed at the bottom of this box. bNumber of participants who moved from the Trondheim municipality was estimated from public address catalogues

Mentions: Participating families were recruited between September 2003 and September 2005, and the initial 6 year follow up occurred from December 2009 to December 2011. The 6 year child health questionnaire was completed by 281 (67.7 %) families and 163 (39.3 %) attended the clinical interview (Fig. 1), with no significant difference in attendance rates between the probiotic and placebo groups. Mean age of follow-up at the clinical examination was 6.3 years (SD 0.2 years) in both probiotic and placebo arms. The mean age of completion of the questionnaire was also comparable between treatment arms among both initial and late responders (data not shown).Fig. 1


Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial.

Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T - BMC Dermatol. (2015)

Participant flow diagram. The exact number of women who were invited and or assessed for eligibility is not available. aSeveral children were lost to both questionnaire and examination follow-up as displayed at the bottom of this box. bNumber of participants who moved from the Trondheim municipality was estimated from public address catalogues
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522068&req=5

Fig1: Participant flow diagram. The exact number of women who were invited and or assessed for eligibility is not available. aSeveral children were lost to both questionnaire and examination follow-up as displayed at the bottom of this box. bNumber of participants who moved from the Trondheim municipality was estimated from public address catalogues
Mentions: Participating families were recruited between September 2003 and September 2005, and the initial 6 year follow up occurred from December 2009 to December 2011. The 6 year child health questionnaire was completed by 281 (67.7 %) families and 163 (39.3 %) attended the clinical interview (Fig. 1), with no significant difference in attendance rates between the probiotic and placebo groups. Mean age of follow-up at the clinical examination was 6.3 years (SD 0.2 years) in both probiotic and placebo arms. The mean age of completion of the questionnaire was also comparable between treatment arms among both initial and late responders (data not shown).Fig. 1

Bottom Line: We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation.In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.Maternal probiotic ingestion alone may be sufficient for long term reduction in the cumulative incidence of AD, but not other allergy related diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Postboks 8905, MTFS, 7491, Trondheim, Norway. melanie.simpson@ntnu.no.

ABSTRACT

Background: Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.

Methods: Four hundred and fifteen pregnant women were randomised to receive probiotic or placebo milk in a double-blinded trial from 36 week gestation until 3 months postpartum. Probiotic milk contained Lactobacillus rhamnosos GG, L. acidophilus La-5 and Bifidobacterium animalis subsp. lactis Bb-12. At 6 years, children were re-assessed for AD, atopic sensitisation, asthma and allergic rhinoconjunctivitis (ARC).

Results: At 6 years, 81 and 82 children were assessed for AD in the probiotic and placebo groups, respectively. In a multiple imputation analysis, there was as trend towards a lower cumulative incidence of AD in the probiotic group compared to the placebo group (OR 0.64, 95 % CI 0.39-1.07, p = 0.086; NNT = 10). This finding was statistically significantly in the complete case analysis (OR 0.48, 95 % CI 0.25-0.92, p = 0.027, NNT = 6). The prevalence of asthma and atopic sensitisation, and the cumulative incidence of ARC were not significantly affected by the probiotic regime at 6 years of age.

Conclusions: Maternal probiotic ingestion alone may be sufficient for long term reduction in the cumulative incidence of AD, but not other allergy related diseases.

Trial registration: ClinicalTrials.gov identifier: NCT00159523.

Show MeSH
Related in: MedlinePlus