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Psychometric properties of the incontinence utility index among patients with idiopathic overactive bladder: data from two multicenter, double-blind, randomized, Phase 3, placebo-controlled clinical trials.

Castejón N, Khalaf K, Ni Q, Cuervo J, Patrick DL - Health Qual Life Outcomes (2015)

Bottom Line: Statistically significant differences (p < 0.001) were found in IUI scores for patients improving according to the Treatment Benefit Scale (TBS).Low to moderate correlations (rho:</0.6/) were found with Short Form version 2 (SF-12v2) summary components.A large effect size was found for patients reporting improvement (0.98-1.21) or great improvement (1.87-2.56) in the TBS, as well as in patients responding to treatment (1.19-2.40).

View Article: PubMed Central - PubMed

Affiliation: LA-SER Outcomes, C/ Azcárraga 12 A 33010 Oviedo, Asturias, Spain. nacho.castejon@la-ser.com.

ABSTRACT

Background: Overactive bladder is a prevalent and burdensome condition. Generic utility measures may fail to reflect its full impact on patients' health status. The Incontinence Utility Index (IUI) is a community-based preference index derived from the Incontinence Quality of Life Questionnaire (I-QOL) developed to value health states related to urinary symptoms in patients with neurogenic detrusor overactivity. This study assessed the measurement properties of the IUI in patients with idiopathic overactive bladder (OAB).

Methods: Data were used from two clinical trials which recruited patients with OAB whose symptoms were inadequately managed with ≥ 1 anticholinergic medication. Psychometric evaluation included: Differential Item Functioning (DIF) analysis, concordance between I-QOL and IUI (Intraclass correlation coefficient [ICC], criterion and convergent validity according to relevant patient reported outcomes and clinical variables (Spearman's correlation coefficient, rho), responsiveness, and agreement between utility measures (ICC and Bland-Altman method).

Results: A total of 1,105 idiopathic OAB patients were included. Mean age (range) was 60.4 years (18-90), 87.8% (n = 970) were female. DIF was identified in 3 items, none of which are contained in the IUI. ICC (CI95%) was 0.944 (0.936-0.950). Statistically significant differences (p < 0.001) were found in IUI scores for patients improving according to the Treatment Benefit Scale (TBS). Moderate to strong correlations (rho > /0.6/) were found in the expected direction with daily incontinence, urgency episodes and disease-specific domains of King's Health Questionnaire (KHQ). Low to moderate correlations (rho:

Conclusions: The IUI presents good psychometric properties for valuing the impact of UI-related problems in idiopathic OAB patients.

Trial registration: ClinicalTrials.gov: NCT00910845 and NCT00910520.

No MeSH data available.


Related in: MedlinePlus

Bland-Altman scatterplots: Concordance between Incontinence Utility Index (IUI) and Short Form-12 Health Survey (SF-6D) utility scores
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Fig3: Bland-Altman scatterplots: Concordance between Incontinence Utility Index (IUI) and Short Form-12 Health Survey (SF-6D) utility scores

Mentions: With regards to the concordance between utility values, although the associations between the IUI and the utilities scores from the KHQ and the SF-12 (SF-6D) were significant, positive and moderate to strong (0.761 and 0.469, respectively, p < 0.001) (Table 5), Bland-Altman methods highlighted poor agreement between these measures meaning that large differences in utility values were seen in the scatterplots (Figs. 2, 3 and 4). Mean differences (SD) between utility values from IUI and both KHQ and SF-6D were: −0.70 (0.13) and −0.44 (0.15) at baseline and −0.60 (0.22) and −0.34 (0.22) at week 12, respectively. The agreement between the utility scores obtained from the KHQ and the SF-6D was also low: mean differences of values (SD) was 0.27 (0.12) at baseline and 0.26 (0.12) at week 12, far exceeding acceptable concordance thresholds. This low agreement was confirmed by ICC results: all the comparisons (at baseline and at week 12) were under the accepted threshold (0.7) and ranged from 0.014 to 0.2.Table 5


Psychometric properties of the incontinence utility index among patients with idiopathic overactive bladder: data from two multicenter, double-blind, randomized, Phase 3, placebo-controlled clinical trials.

Castejón N, Khalaf K, Ni Q, Cuervo J, Patrick DL - Health Qual Life Outcomes (2015)

Bland-Altman scatterplots: Concordance between Incontinence Utility Index (IUI) and Short Form-12 Health Survey (SF-6D) utility scores
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522067&req=5

Fig3: Bland-Altman scatterplots: Concordance between Incontinence Utility Index (IUI) and Short Form-12 Health Survey (SF-6D) utility scores
Mentions: With regards to the concordance between utility values, although the associations between the IUI and the utilities scores from the KHQ and the SF-12 (SF-6D) were significant, positive and moderate to strong (0.761 and 0.469, respectively, p < 0.001) (Table 5), Bland-Altman methods highlighted poor agreement between these measures meaning that large differences in utility values were seen in the scatterplots (Figs. 2, 3 and 4). Mean differences (SD) between utility values from IUI and both KHQ and SF-6D were: −0.70 (0.13) and −0.44 (0.15) at baseline and −0.60 (0.22) and −0.34 (0.22) at week 12, respectively. The agreement between the utility scores obtained from the KHQ and the SF-6D was also low: mean differences of values (SD) was 0.27 (0.12) at baseline and 0.26 (0.12) at week 12, far exceeding acceptable concordance thresholds. This low agreement was confirmed by ICC results: all the comparisons (at baseline and at week 12) were under the accepted threshold (0.7) and ranged from 0.014 to 0.2.Table 5

Bottom Line: Statistically significant differences (p < 0.001) were found in IUI scores for patients improving according to the Treatment Benefit Scale (TBS).Low to moderate correlations (rho:</0.6/) were found with Short Form version 2 (SF-12v2) summary components.A large effect size was found for patients reporting improvement (0.98-1.21) or great improvement (1.87-2.56) in the TBS, as well as in patients responding to treatment (1.19-2.40).

View Article: PubMed Central - PubMed

Affiliation: LA-SER Outcomes, C/ Azcárraga 12 A 33010 Oviedo, Asturias, Spain. nacho.castejon@la-ser.com.

ABSTRACT

Background: Overactive bladder is a prevalent and burdensome condition. Generic utility measures may fail to reflect its full impact on patients' health status. The Incontinence Utility Index (IUI) is a community-based preference index derived from the Incontinence Quality of Life Questionnaire (I-QOL) developed to value health states related to urinary symptoms in patients with neurogenic detrusor overactivity. This study assessed the measurement properties of the IUI in patients with idiopathic overactive bladder (OAB).

Methods: Data were used from two clinical trials which recruited patients with OAB whose symptoms were inadequately managed with ≥ 1 anticholinergic medication. Psychometric evaluation included: Differential Item Functioning (DIF) analysis, concordance between I-QOL and IUI (Intraclass correlation coefficient [ICC], criterion and convergent validity according to relevant patient reported outcomes and clinical variables (Spearman's correlation coefficient, rho), responsiveness, and agreement between utility measures (ICC and Bland-Altman method).

Results: A total of 1,105 idiopathic OAB patients were included. Mean age (range) was 60.4 years (18-90), 87.8% (n = 970) were female. DIF was identified in 3 items, none of which are contained in the IUI. ICC (CI95%) was 0.944 (0.936-0.950). Statistically significant differences (p < 0.001) were found in IUI scores for patients improving according to the Treatment Benefit Scale (TBS). Moderate to strong correlations (rho > /0.6/) were found in the expected direction with daily incontinence, urgency episodes and disease-specific domains of King's Health Questionnaire (KHQ). Low to moderate correlations (rho:

Conclusions: The IUI presents good psychometric properties for valuing the impact of UI-related problems in idiopathic OAB patients.

Trial registration: ClinicalTrials.gov: NCT00910845 and NCT00910520.

No MeSH data available.


Related in: MedlinePlus