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The mechanisms by which antidepressants may reduce coronary heart disease risk.

Mathews MJ, Mathews EH, Liebenberg L - BMC Cardiovasc Disord (2015)

Bottom Line: Using biomarker relative risk data the pathogenetic effects are representable as measurable effects based on changes in biomarkers.The use of selective serotonin reuptake inhibitors (SSRIs) is postulated to have potential to decrease CHD risk.These effects might be mediated with the use of SSRI's.

View Article: PubMed Central - PubMed

Affiliation: CRCED Pretoria, North-West University, P.O. Box 11207, Silver Lakes, 0054, South Africa. mjmathews@rems2.com.

ABSTRACT

Background: Depression is known to increase the risk for coronary heart disease (CHD) likely through various pathogenetic actions. Understanding the links between depression and CHD and the effects of mediating these links may prove beneficial in CHD prevention.

Methods: An integrated model of CHD was used to elucidate pathogenetic pathways of importance between depression and CHD. Using biomarker relative risk data the pathogenetic effects are representable as measurable effects based on changes in biomarkers.

Results: A 'connection graph' presents interactions by illustrating the relationship between depression and the biomarkers of CHD. The use of selective serotonin reuptake inhibitors (SSRIs) is postulated to have potential to decrease CHD risk. Comparing the 'connection graph' of SSRI's to that of depression elucidates the possible actions through which risk reduction may occur.

Conclusions: The CHD effects of depression appear to be driven by increased inflammation and altered metabolism. These effects might be mediated with the use of SSRI's.

No MeSH data available.


Related in: MedlinePlus

Normalized relative risks (fold-change) of salient current biomarkers or of potential serological biomarkers for CHD. Note. From “How do high glycemic load diets influence coronary heart disease?” by Mathews M, Liebenberg L, Mathews EH Nutr Metab 2015;12:6 [9]. Increased IGF-1 and HDL levels are associated with a moderately decreased CHD risk. (IGF-1 and HDL levels are significantly inversely correlated to relative risk for CHD.) N indicates number of trials; I, standard error; ACR, albumin-to-creatinine ratio; Adipo, adiponectin; ApoB, apolipoprotein-B; BDNF, brain-derived neurotrophic factor; BNP, B-type natriuretic peptide; Cort, cortisol; CRP, C-reactive protein; Cysteine, Homocysteine; Fibrin, fibrinogen; GDF-15, growth-differentiation factor-15; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; IL-6, interleukin-6; IGF-1, insulin-like growth factor-1; LDL, low-density lipoprotein; MPO, myeloperoxidase; RANKL or OPG, osteoprotegerin; TNF-α, tumor necrosis factor-α; Trop, troponins; Trigl, triglycerides
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Fig2: Normalized relative risks (fold-change) of salient current biomarkers or of potential serological biomarkers for CHD. Note. From “How do high glycemic load diets influence coronary heart disease?” by Mathews M, Liebenberg L, Mathews EH Nutr Metab 2015;12:6 [9]. Increased IGF-1 and HDL levels are associated with a moderately decreased CHD risk. (IGF-1 and HDL levels are significantly inversely correlated to relative risk for CHD.) N indicates number of trials; I, standard error; ACR, albumin-to-creatinine ratio; Adipo, adiponectin; ApoB, apolipoprotein-B; BDNF, brain-derived neurotrophic factor; BNP, B-type natriuretic peptide; Cort, cortisol; CRP, C-reactive protein; Cysteine, Homocysteine; Fibrin, fibrinogen; GDF-15, growth-differentiation factor-15; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; IL-6, interleukin-6; IGF-1, insulin-like growth factor-1; LDL, low-density lipoprotein; MPO, myeloperoxidase; RANKL or OPG, osteoprotegerin; TNF-α, tumor necrosis factor-α; Trop, troponins; Trigl, triglycerides

Mentions: To simplify the integrated model, serological biomarkers (which can be easily measured) are used to link the effect of depression to the corresponding RR of CHD. Figure 2 presents a comparison of the RR associated with an array of serological biomarkers per 1-standard deviation increase in the biomarker [9].Fig. 2


The mechanisms by which antidepressants may reduce coronary heart disease risk.

Mathews MJ, Mathews EH, Liebenberg L - BMC Cardiovasc Disord (2015)

Normalized relative risks (fold-change) of salient current biomarkers or of potential serological biomarkers for CHD. Note. From “How do high glycemic load diets influence coronary heart disease?” by Mathews M, Liebenberg L, Mathews EH Nutr Metab 2015;12:6 [9]. Increased IGF-1 and HDL levels are associated with a moderately decreased CHD risk. (IGF-1 and HDL levels are significantly inversely correlated to relative risk for CHD.) N indicates number of trials; I, standard error; ACR, albumin-to-creatinine ratio; Adipo, adiponectin; ApoB, apolipoprotein-B; BDNF, brain-derived neurotrophic factor; BNP, B-type natriuretic peptide; Cort, cortisol; CRP, C-reactive protein; Cysteine, Homocysteine; Fibrin, fibrinogen; GDF-15, growth-differentiation factor-15; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; IL-6, interleukin-6; IGF-1, insulin-like growth factor-1; LDL, low-density lipoprotein; MPO, myeloperoxidase; RANKL or OPG, osteoprotegerin; TNF-α, tumor necrosis factor-α; Trop, troponins; Trigl, triglycerides
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4522054&req=5

Fig2: Normalized relative risks (fold-change) of salient current biomarkers or of potential serological biomarkers for CHD. Note. From “How do high glycemic load diets influence coronary heart disease?” by Mathews M, Liebenberg L, Mathews EH Nutr Metab 2015;12:6 [9]. Increased IGF-1 and HDL levels are associated with a moderately decreased CHD risk. (IGF-1 and HDL levels are significantly inversely correlated to relative risk for CHD.) N indicates number of trials; I, standard error; ACR, albumin-to-creatinine ratio; Adipo, adiponectin; ApoB, apolipoprotein-B; BDNF, brain-derived neurotrophic factor; BNP, B-type natriuretic peptide; Cort, cortisol; CRP, C-reactive protein; Cysteine, Homocysteine; Fibrin, fibrinogen; GDF-15, growth-differentiation factor-15; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; IL-6, interleukin-6; IGF-1, insulin-like growth factor-1; LDL, low-density lipoprotein; MPO, myeloperoxidase; RANKL or OPG, osteoprotegerin; TNF-α, tumor necrosis factor-α; Trop, troponins; Trigl, triglycerides
Mentions: To simplify the integrated model, serological biomarkers (which can be easily measured) are used to link the effect of depression to the corresponding RR of CHD. Figure 2 presents a comparison of the RR associated with an array of serological biomarkers per 1-standard deviation increase in the biomarker [9].Fig. 2

Bottom Line: Using biomarker relative risk data the pathogenetic effects are representable as measurable effects based on changes in biomarkers.The use of selective serotonin reuptake inhibitors (SSRIs) is postulated to have potential to decrease CHD risk.These effects might be mediated with the use of SSRI's.

View Article: PubMed Central - PubMed

Affiliation: CRCED Pretoria, North-West University, P.O. Box 11207, Silver Lakes, 0054, South Africa. mjmathews@rems2.com.

ABSTRACT

Background: Depression is known to increase the risk for coronary heart disease (CHD) likely through various pathogenetic actions. Understanding the links between depression and CHD and the effects of mediating these links may prove beneficial in CHD prevention.

Methods: An integrated model of CHD was used to elucidate pathogenetic pathways of importance between depression and CHD. Using biomarker relative risk data the pathogenetic effects are representable as measurable effects based on changes in biomarkers.

Results: A 'connection graph' presents interactions by illustrating the relationship between depression and the biomarkers of CHD. The use of selective serotonin reuptake inhibitors (SSRIs) is postulated to have potential to decrease CHD risk. Comparing the 'connection graph' of SSRI's to that of depression elucidates the possible actions through which risk reduction may occur.

Conclusions: The CHD effects of depression appear to be driven by increased inflammation and altered metabolism. These effects might be mediated with the use of SSRI's.

No MeSH data available.


Related in: MedlinePlus