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Local Activity and Causal Connectivity in Children with Benign Epilepsy with Centrotemporal Spikes.

Wu Y, Ji GJ, Zang YF, Liao W, Jin Z, Liu YL, Li K, Zeng YW, Fang F - PLoS ONE (2015)

Bottom Line: Granger causality analysis was applied to explore the causal effect between EZ and the whole brain.Compared with controls, the patients showed increased driving effect from the EZ to the right medial frontal cortex and posterior cingulate cortex and decreased causal effects from the EZ to left inferior frontal gyrus.The causal effect of the left inferior frontal gyrus negatively correlated with disease duration, which suggests a relation between the epileptiform activity and language impairment.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China.

ABSTRACT
The aim of the current study was to localize the epileptic focus and characterize its causal relation with other brain regions, to understand the cognitive deficits in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) was performed in 37 children with BECTS and 25 children matched for age, sex and educational achievement. We identified the potential epileptogenic zone (EZ) by comparing the amplitude of low frequency fluctuation (ALFF) of spontaneous blood oxygenation level dependent fMRI signals between the groups. Granger causality analysis was applied to explore the causal effect between EZ and the whole brain. Compared with controls, children with BECTS had significantly increased ALFF in the right postcentral gyrus and bilateral calcarine, and decreased ALFF in the left anterior cingulate cortex, bilateral putaman/caudate, and left cerebellum. ALFF values in the putaman/caudate were positively correlated with verbal IQ scores in patients. The ALFF values in cerebellum and performance IQ scores were negatively correlated in patients. These results suggest that ALFF disturbances in the putaman/caudate and cerebellum play an important role in BECTS cognitive dysfunction. Compared with controls, the patients showed increased driving effect from the EZ to the right medial frontal cortex and posterior cingulate cortex and decreased causal effects from the EZ to left inferior frontal gyrus. The causal effect of the left inferior frontal gyrus negatively correlated with disease duration, which suggests a relation between the epileptiform activity and language impairment. All together, these findings provide additional insight into the neurophysiological mechanisms of epilepitogenisis and cognitive dysfunction associated with BECTS.

No MeSH data available.


Related in: MedlinePlus

Correlation between fMRI measures and cognitive estimation or disease duration.(A) A positive correlation was identified for ALFF values in the putamen/caudate and VIQ scores. There were four children had same scores of verbal IQ(90), 4 points overlapping together, so there were only 22 points in the this figure. (B) The cerebellum and PIQ scores showed a negative correlation. (C) The causal effect from EZ to the left inferior frontal gyrus was negatively correlated with disease duration.
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pone.0134361.g003: Correlation between fMRI measures and cognitive estimation or disease duration.(A) A positive correlation was identified for ALFF values in the putamen/caudate and VIQ scores. There were four children had same scores of verbal IQ(90), 4 points overlapping together, so there were only 22 points in the this figure. (B) The cerebellum and PIQ scores showed a negative correlation. (C) The causal effect from EZ to the left inferior frontal gyrus was negatively correlated with disease duration.

Mentions: A positive correlation was identified for ALFF values in the putamen/caudate and VIQ scores (r = 0.521, P = 0.009) (Fig 3A). In contrast, the cerebellum and PIQ scores showed a negative correlation (r = −0.441, P = 0.031) (Fig 3B). The causal effect from EZ to the left inferior frontal gyrus (r = −0.393, P = 0.02) was negatively correlated with disease duration (Fig 3C). These associations were absent in the healthy controls.


Local Activity and Causal Connectivity in Children with Benign Epilepsy with Centrotemporal Spikes.

Wu Y, Ji GJ, Zang YF, Liao W, Jin Z, Liu YL, Li K, Zeng YW, Fang F - PLoS ONE (2015)

Correlation between fMRI measures and cognitive estimation or disease duration.(A) A positive correlation was identified for ALFF values in the putamen/caudate and VIQ scores. There were four children had same scores of verbal IQ(90), 4 points overlapping together, so there were only 22 points in the this figure. (B) The cerebellum and PIQ scores showed a negative correlation. (C) The causal effect from EZ to the left inferior frontal gyrus was negatively correlated with disease duration.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4520539&req=5

pone.0134361.g003: Correlation between fMRI measures and cognitive estimation or disease duration.(A) A positive correlation was identified for ALFF values in the putamen/caudate and VIQ scores. There were four children had same scores of verbal IQ(90), 4 points overlapping together, so there were only 22 points in the this figure. (B) The cerebellum and PIQ scores showed a negative correlation. (C) The causal effect from EZ to the left inferior frontal gyrus was negatively correlated with disease duration.
Mentions: A positive correlation was identified for ALFF values in the putamen/caudate and VIQ scores (r = 0.521, P = 0.009) (Fig 3A). In contrast, the cerebellum and PIQ scores showed a negative correlation (r = −0.441, P = 0.031) (Fig 3B). The causal effect from EZ to the left inferior frontal gyrus (r = −0.393, P = 0.02) was negatively correlated with disease duration (Fig 3C). These associations were absent in the healthy controls.

Bottom Line: Granger causality analysis was applied to explore the causal effect between EZ and the whole brain.Compared with controls, the patients showed increased driving effect from the EZ to the right medial frontal cortex and posterior cingulate cortex and decreased causal effects from the EZ to left inferior frontal gyrus.The causal effect of the left inferior frontal gyrus negatively correlated with disease duration, which suggests a relation between the epileptiform activity and language impairment.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China.

ABSTRACT
The aim of the current study was to localize the epileptic focus and characterize its causal relation with other brain regions, to understand the cognitive deficits in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Resting-state functional magnetic resonance imaging (fMRI) was performed in 37 children with BECTS and 25 children matched for age, sex and educational achievement. We identified the potential epileptogenic zone (EZ) by comparing the amplitude of low frequency fluctuation (ALFF) of spontaneous blood oxygenation level dependent fMRI signals between the groups. Granger causality analysis was applied to explore the causal effect between EZ and the whole brain. Compared with controls, children with BECTS had significantly increased ALFF in the right postcentral gyrus and bilateral calcarine, and decreased ALFF in the left anterior cingulate cortex, bilateral putaman/caudate, and left cerebellum. ALFF values in the putaman/caudate were positively correlated with verbal IQ scores in patients. The ALFF values in cerebellum and performance IQ scores were negatively correlated in patients. These results suggest that ALFF disturbances in the putaman/caudate and cerebellum play an important role in BECTS cognitive dysfunction. Compared with controls, the patients showed increased driving effect from the EZ to the right medial frontal cortex and posterior cingulate cortex and decreased causal effects from the EZ to left inferior frontal gyrus. The causal effect of the left inferior frontal gyrus negatively correlated with disease duration, which suggests a relation between the epileptiform activity and language impairment. All together, these findings provide additional insight into the neurophysiological mechanisms of epilepitogenisis and cognitive dysfunction associated with BECTS.

No MeSH data available.


Related in: MedlinePlus