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Malignant melanoma of the lung: case series.

Postrzech-Adamczyk K, Chabowski M, Głuszczyk-Ferenc B, Wodzińska A, Muszczyńska-Bernhard B, Szuba A, Janczak D - Kardiochir Torakochirurgia Pol (2015)

Bottom Line: For the diagnosis of primary lung melanoma, strict histopathological and clinical criteria should be met.The first 2 case studies present primary lung melanomas, while the last one shows late lung metastasis of tumor originated from vaginal mucosa.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, 4 Clinical Military Hospital, Wroclaw, Poland.

ABSTRACT
Extracutaneous locations of primary malignant melanoma are rare. In the respiratory system most melanomas present as metastatic tumors. For the diagnosis of primary lung melanoma, strict histopathological and clinical criteria should be met. In this paper we present three cases of malignant melanoma which showed in the respiratory system. The first 2 case studies present primary lung melanomas, while the last one shows late lung metastasis of tumor originated from vaginal mucosa. The treatment of choice for localized disease as well as single metastasis is surgical excision.

No MeSH data available.


Related in: MedlinePlus

A) HE stain: bronchial mucosa infiltrated by epithelioid tumor cells. Some of them contain a dye in the cytoplasm. B) Immunohistochemistry: Melan A-positive reaction. C) Immunohistochemistry: panCK-negative reaction
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Figure 0002: A) HE stain: bronchial mucosa infiltrated by epithelioid tumor cells. Some of them contain a dye in the cytoplasm. B) Immunohistochemistry: Melan A-positive reaction. C) Immunohistochemistry: panCK-negative reaction

Mentions: A 69-year-old female was admitted to the Department of Pulmonology with a history of persistent cough and exertional dyspnea. Chest X-ray showed atelectasis of the right upper lobe and solid tumor in the same area. Computed tomography (CT) revealed a large solid and cystic lesion in the upper right lobe expanding from the apex along the anterior chest wall. Additionally paratracheal, inferior tracheobronchial, sub- and supraclavicular lymph nodes were enlarged (Fig. 1). Positron emission tomography (PET) scan showed no other malignancy except for findings in CT. Bronchoscopy exposed a darkly pigmented, endobronchial mass obstructing the right upper lobe bronchus, visually mimicking thrombus. Cytological examination revealed non-small cell cancer, but full histopathological examination resulted in the diagnosis of malignant melanoma. Immunohistochemistry of tissue biopsy tested positive for S100 protein, HMB45, Melanin A and negative for panCK, TTF1, CK7, p63 and CK5/6 (Fig. 2). The patient was qualified to adjuvant chemotherapy, unfortunately progression of the disease was observed and the patient died 6 months after diagnosis.


Malignant melanoma of the lung: case series.

Postrzech-Adamczyk K, Chabowski M, Głuszczyk-Ferenc B, Wodzińska A, Muszczyńska-Bernhard B, Szuba A, Janczak D - Kardiochir Torakochirurgia Pol (2015)

A) HE stain: bronchial mucosa infiltrated by epithelioid tumor cells. Some of them contain a dye in the cytoplasm. B) Immunohistochemistry: Melan A-positive reaction. C) Immunohistochemistry: panCK-negative reaction
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4520507&req=5

Figure 0002: A) HE stain: bronchial mucosa infiltrated by epithelioid tumor cells. Some of them contain a dye in the cytoplasm. B) Immunohistochemistry: Melan A-positive reaction. C) Immunohistochemistry: panCK-negative reaction
Mentions: A 69-year-old female was admitted to the Department of Pulmonology with a history of persistent cough and exertional dyspnea. Chest X-ray showed atelectasis of the right upper lobe and solid tumor in the same area. Computed tomography (CT) revealed a large solid and cystic lesion in the upper right lobe expanding from the apex along the anterior chest wall. Additionally paratracheal, inferior tracheobronchial, sub- and supraclavicular lymph nodes were enlarged (Fig. 1). Positron emission tomography (PET) scan showed no other malignancy except for findings in CT. Bronchoscopy exposed a darkly pigmented, endobronchial mass obstructing the right upper lobe bronchus, visually mimicking thrombus. Cytological examination revealed non-small cell cancer, but full histopathological examination resulted in the diagnosis of malignant melanoma. Immunohistochemistry of tissue biopsy tested positive for S100 protein, HMB45, Melanin A and negative for panCK, TTF1, CK7, p63 and CK5/6 (Fig. 2). The patient was qualified to adjuvant chemotherapy, unfortunately progression of the disease was observed and the patient died 6 months after diagnosis.

Bottom Line: For the diagnosis of primary lung melanoma, strict histopathological and clinical criteria should be met.The first 2 case studies present primary lung melanomas, while the last one shows late lung metastasis of tumor originated from vaginal mucosa.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, 4 Clinical Military Hospital, Wroclaw, Poland.

ABSTRACT
Extracutaneous locations of primary malignant melanoma are rare. In the respiratory system most melanomas present as metastatic tumors. For the diagnosis of primary lung melanoma, strict histopathological and clinical criteria should be met. In this paper we present three cases of malignant melanoma which showed in the respiratory system. The first 2 case studies present primary lung melanomas, while the last one shows late lung metastasis of tumor originated from vaginal mucosa. The treatment of choice for localized disease as well as single metastasis is surgical excision.

No MeSH data available.


Related in: MedlinePlus