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Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress.

Rukhlenko OS, Dudchenko OA, Zlobina KE, Guria GT - PLoS ONE (2015)

Bottom Line: Numerical analysis of the model reveals the existence of two hydrodynamic thresholds for activation of blood coagulation in the system and unveils typical scenarios of thrombus formation.Relevant parametric diagrams are drawn.The results suggest a previously unrecognized role of relatively small plaques (resulting in less than 50% of the lumen area reduction) in atherothrombosis and have important implications for the existing stenting guidelines.

View Article: PubMed Central - PubMed

Affiliation: National Research Center for Hematology, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Cherkasy National University, Cherkasy, Ukraine.

ABSTRACT
Increased shear stress such as observed at local stenosis may cause drastic changes in the permeability of the vessel wall to procoagulants and thus initiate intravascular blood coagulation. In this paper we suggest a mathematical model to investigate how shear stress-induced permeability influences the thrombogenic potential of atherosclerotic plaques. Numerical analysis of the model reveals the existence of two hydrodynamic thresholds for activation of blood coagulation in the system and unveils typical scenarios of thrombus formation. The dependence of blood coagulation development on the intensity of blood flow, as well as on geometrical parameters of atherosclerotic plaque is described. Relevant parametric diagrams are drawn. The results suggest a previously unrecognized role of relatively small plaques (resulting in less than 50% of the lumen area reduction) in atherothrombosis and have important implications for the existing stenting guidelines.

No MeSH data available.


Related in: MedlinePlus

Parametric diagrams of blood coagulation regimes in the (h, Re) parameter space for two different values of , the non-dimensional plaque diameter.Region “I” denotes regimes in which there is no coagulation, region “II” represents regimes of macroscopic thrombus formation. (a): , ; (b): , .
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pone.0134028.g003: Parametric diagrams of blood coagulation regimes in the (h, Re) parameter space for two different values of , the non-dimensional plaque diameter.Region “I” denotes regimes in which there is no coagulation, region “II” represents regimes of macroscopic thrombus formation. (a): , ; (b): , .

Mentions: We further investigated the coagulation regimes by exploring the influence of stenosis geometry on thrombus formation. Fig 3 shows the parametric diagrams in the (h, Re) space for two values of plaque width . As in Fig 2 zone “I” corresponds to stable liquid states (no coagulation) and zone “II” corresponds to thrombus formation.


Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress.

Rukhlenko OS, Dudchenko OA, Zlobina KE, Guria GT - PLoS ONE (2015)

Parametric diagrams of blood coagulation regimes in the (h, Re) parameter space for two different values of , the non-dimensional plaque diameter.Region “I” denotes regimes in which there is no coagulation, region “II” represents regimes of macroscopic thrombus formation. (a): , ; (b): , .
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4519339&req=5

pone.0134028.g003: Parametric diagrams of blood coagulation regimes in the (h, Re) parameter space for two different values of , the non-dimensional plaque diameter.Region “I” denotes regimes in which there is no coagulation, region “II” represents regimes of macroscopic thrombus formation. (a): , ; (b): , .
Mentions: We further investigated the coagulation regimes by exploring the influence of stenosis geometry on thrombus formation. Fig 3 shows the parametric diagrams in the (h, Re) space for two values of plaque width . As in Fig 2 zone “I” corresponds to stable liquid states (no coagulation) and zone “II” corresponds to thrombus formation.

Bottom Line: Numerical analysis of the model reveals the existence of two hydrodynamic thresholds for activation of blood coagulation in the system and unveils typical scenarios of thrombus formation.Relevant parametric diagrams are drawn.The results suggest a previously unrecognized role of relatively small plaques (resulting in less than 50% of the lumen area reduction) in atherothrombosis and have important implications for the existing stenting guidelines.

View Article: PubMed Central - PubMed

Affiliation: National Research Center for Hematology, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Russia; Cherkasy National University, Cherkasy, Ukraine.

ABSTRACT
Increased shear stress such as observed at local stenosis may cause drastic changes in the permeability of the vessel wall to procoagulants and thus initiate intravascular blood coagulation. In this paper we suggest a mathematical model to investigate how shear stress-induced permeability influences the thrombogenic potential of atherosclerotic plaques. Numerical analysis of the model reveals the existence of two hydrodynamic thresholds for activation of blood coagulation in the system and unveils typical scenarios of thrombus formation. The dependence of blood coagulation development on the intensity of blood flow, as well as on geometrical parameters of atherosclerotic plaque is described. Relevant parametric diagrams are drawn. The results suggest a previously unrecognized role of relatively small plaques (resulting in less than 50% of the lumen area reduction) in atherothrombosis and have important implications for the existing stenting guidelines.

No MeSH data available.


Related in: MedlinePlus