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Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study.

Wolf RM, Steele KE, Peterson LA, Magnuson TH, Schweitzer MA, Wong GW - PLoS ONE (2015)

Bottom Line: We found significantly lower circulating levels of CTRP3 in obese individuals (405 ± 8.3 vs. 436 ± 6.7 ng/mL, p=0.004) compared to the lean group.We found BMI (p<0.01), gender (p<0.01), and ethnicity (p<0.05) to be significant predictors of CTRP3 levels when controlling for age in multiple regression analysis.CTRP3 is a beneficial adipokine whose circulating levels are significantly lower in obese individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, United States of America; The Center for Metabolism and Obesity Research The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, United States of America.

ABSTRACT

Purpose: C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that lowers blood glucose levels, reduces liver triglyceride synthesis, and is protective against hepatic steatosis in diet-induced obese mouse models. We hypothesized that higher circulating serum levels of CTRP3 would be associated with a lean body mass index (BMI) and a more favorable metabolic profile in humans. The aim of this study was to investigate CTRP3 levels in lean individuals compared to obese individuals.

Methods: This was a cross-sectional study of obese (n=44) and lean control patients (n=60). Fasting metabolic parameters were measured in all patients and serum CTRP3 levels were measured by ELISA.

Results: BMI of the lean group was 21.9 ± 0.2 kg/m2 and obese group was 45.2 ± 1.1 kg/m2. We found significantly lower circulating levels of CTRP3 in obese individuals (405 ± 8.3 vs. 436 ± 6.7 ng/mL, p=0.004) compared to the lean group. Serum CTRP3 levels were inversely correlated with BMI (p=0.001), and triglycerides (p<0.001), and significantly associated with gender (p<0.01), ethnicity (p=0.05), HDL-cholesterol (p<0.01), and adiponectin (p<0.01). We found BMI (p<0.01), gender (p<0.01), and ethnicity (p<0.05) to be significant predictors of CTRP3 levels when controlling for age in multiple regression analysis.

Conclusions: CTRP3 is a beneficial adipokine whose circulating levels are significantly lower in obese individuals. Obesity causes dysregulation in adipokine production, including the down-regulation of CTRP3. Lower CTRP3 levels may contribute to the pathophysiology of metabolic disorders associated with obesity. Optimizing CTRP3 levels through novel therapies may improve obesity and its comorbidities.

No MeSH data available.


Related in: MedlinePlus

(A) and (B) CTRP3 is inversely related to BMI, analogous to adiponectin. (A) and (C) CTRP3 and Leptin have opposite relationships with BMI.Pearson’s r = correlation coefficient (p<0.05).
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pone.0133955.g001: (A) and (B) CTRP3 is inversely related to BMI, analogous to adiponectin. (A) and (C) CTRP3 and Leptin have opposite relationships with BMI.Pearson’s r = correlation coefficient (p<0.05).

Mentions: There was no difference in CTRP3 levels by age, but men had significantly lower CTRP3 levels compared to women (397.7 vs. 432 ng/mL, p<0.01). CTRP3 levels differed among ethnic groups (p = 0.05). When categorized as White vs. non-White (Black, Asian, and Hispanic), White patients had significantly lower mean CTRP3 levels (413.78 vs. 442.35 ng/mL, p = 0.01) compared to other ethnic groups. As shown in Table 2, in the lean controls, CTRP3 was correlated with leptin (p<0.01), and was borderline significant when correlated with HDL-cholesterol (p = 0.05). In obese patients, CTRP3 was inversely correlated with triglyceride levels (p<0.05). In the overall cohort, CTRP3 was inversely correlated with BMI (p = 0.001), triglycerides (p<0.001), and HOMA-IR (p = 0.05), and positively correlated with HDL-cholesterol (p<0.01), and adiponectin (p<0.01). CTRP3 was associated with gender (p<0.01) and ethnicity (p = 0.05). CTRP3 and adiponectin are both inversely correlated with BMI, whereas leptin has a positive relationship with BMI. (Fig 1)


Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study.

Wolf RM, Steele KE, Peterson LA, Magnuson TH, Schweitzer MA, Wong GW - PLoS ONE (2015)

(A) and (B) CTRP3 is inversely related to BMI, analogous to adiponectin. (A) and (C) CTRP3 and Leptin have opposite relationships with BMI.Pearson’s r = correlation coefficient (p<0.05).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4519328&req=5

pone.0133955.g001: (A) and (B) CTRP3 is inversely related to BMI, analogous to adiponectin. (A) and (C) CTRP3 and Leptin have opposite relationships with BMI.Pearson’s r = correlation coefficient (p<0.05).
Mentions: There was no difference in CTRP3 levels by age, but men had significantly lower CTRP3 levels compared to women (397.7 vs. 432 ng/mL, p<0.01). CTRP3 levels differed among ethnic groups (p = 0.05). When categorized as White vs. non-White (Black, Asian, and Hispanic), White patients had significantly lower mean CTRP3 levels (413.78 vs. 442.35 ng/mL, p = 0.01) compared to other ethnic groups. As shown in Table 2, in the lean controls, CTRP3 was correlated with leptin (p<0.01), and was borderline significant when correlated with HDL-cholesterol (p = 0.05). In obese patients, CTRP3 was inversely correlated with triglyceride levels (p<0.05). In the overall cohort, CTRP3 was inversely correlated with BMI (p = 0.001), triglycerides (p<0.001), and HOMA-IR (p = 0.05), and positively correlated with HDL-cholesterol (p<0.01), and adiponectin (p<0.01). CTRP3 was associated with gender (p<0.01) and ethnicity (p = 0.05). CTRP3 and adiponectin are both inversely correlated with BMI, whereas leptin has a positive relationship with BMI. (Fig 1)

Bottom Line: We found significantly lower circulating levels of CTRP3 in obese individuals (405 ± 8.3 vs. 436 ± 6.7 ng/mL, p=0.004) compared to the lean group.We found BMI (p<0.01), gender (p<0.01), and ethnicity (p<0.05) to be significant predictors of CTRP3 levels when controlling for age in multiple regression analysis.CTRP3 is a beneficial adipokine whose circulating levels are significantly lower in obese individuals.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, United States of America; The Center for Metabolism and Obesity Research The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, United States of America.

ABSTRACT

Purpose: C1q/TNF-related protein-3 (CTRP3) is a novel adipokine that lowers blood glucose levels, reduces liver triglyceride synthesis, and is protective against hepatic steatosis in diet-induced obese mouse models. We hypothesized that higher circulating serum levels of CTRP3 would be associated with a lean body mass index (BMI) and a more favorable metabolic profile in humans. The aim of this study was to investigate CTRP3 levels in lean individuals compared to obese individuals.

Methods: This was a cross-sectional study of obese (n=44) and lean control patients (n=60). Fasting metabolic parameters were measured in all patients and serum CTRP3 levels were measured by ELISA.

Results: BMI of the lean group was 21.9 ± 0.2 kg/m2 and obese group was 45.2 ± 1.1 kg/m2. We found significantly lower circulating levels of CTRP3 in obese individuals (405 ± 8.3 vs. 436 ± 6.7 ng/mL, p=0.004) compared to the lean group. Serum CTRP3 levels were inversely correlated with BMI (p=0.001), and triglycerides (p<0.001), and significantly associated with gender (p<0.01), ethnicity (p=0.05), HDL-cholesterol (p<0.01), and adiponectin (p<0.01). We found BMI (p<0.01), gender (p<0.01), and ethnicity (p<0.05) to be significant predictors of CTRP3 levels when controlling for age in multiple regression analysis.

Conclusions: CTRP3 is a beneficial adipokine whose circulating levels are significantly lower in obese individuals. Obesity causes dysregulation in adipokine production, including the down-regulation of CTRP3. Lower CTRP3 levels may contribute to the pathophysiology of metabolic disorders associated with obesity. Optimizing CTRP3 levels through novel therapies may improve obesity and its comorbidities.

No MeSH data available.


Related in: MedlinePlus