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BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a Potential Biomarker in Ovarian Cancer.

Chao A, Tsai CL, Jung SM, Chuang WC, Kao C, Hsu A, Chen SH, Lin CY, Lee YC, Lee YS, Wang TH, Wang HS, Lai CH - PLoS ONE (2015)

Bottom Line: Brain-specific angiogenesis inhibitor 1 (BAI1)-associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration.BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma.Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

ABSTRACT
Brain-specific angiogenesis inhibitor 1 (BAI1)-associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration. BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma. In this study, we report the first comprehensive study of BAIAP2L1 upregulation in human ovarian cancer. Upregulation of BAIAP2L1 in ovarian tumors was first found during RNA screening and confirmed by immunohistochemical studies on ovarian cancers and other cancer types. Significant upregulation of BAIAP2L1 in ovarian cancer was validated by analyzing multiple independent cohorts in publicly available data sets. Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors. Functional assays in ovarian cancer cells revealed that BAIAP2L1 is involved in promoting cell proliferation and avoiding apoptosis. In conclusion, results of this study not only indicate that BAIAP2L1 can be used as a biomarker for human ovarian cancer but also reveal its role in cancer biology. Further elucidation of the role of BAIAP2L1 in context of the insulin receptor signaling pathways of cancer cells is warranted for developing cancer therapeutics by targeting cancer-specific metabolism.

No MeSH data available.


Related in: MedlinePlus

Significantly high expression of BAIAP2L1 in ovarian cancer tissues and ovarian cancer cell lines.(A) The mRNA expression levels of BAIAP2L1 in ovarian cancer epithelial cells (CEPI) isolated from12 ovarian serous adenocarcinoma and ovarian surface epithelium (OSE) from 12 normal human ovaries. Data are retrieved from GSE14407. (B) The expression levels of BAIAP2L1 in tissues of ovarian cancer (OV, n = 182) and cancer of other primary sites (n = 1680). Data are retrieved from GSE36133. (C) The expression levels of BAIAP2L1 in cell lines of ovarian cancer (OV, n = 49) and other origins (n = 972). Data are retrieved from GSE2109.
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pone.0133081.g005: Significantly high expression of BAIAP2L1 in ovarian cancer tissues and ovarian cancer cell lines.(A) The mRNA expression levels of BAIAP2L1 in ovarian cancer epithelial cells (CEPI) isolated from12 ovarian serous adenocarcinoma and ovarian surface epithelium (OSE) from 12 normal human ovaries. Data are retrieved from GSE14407. (B) The expression levels of BAIAP2L1 in tissues of ovarian cancer (OV, n = 182) and cancer of other primary sites (n = 1680). Data are retrieved from GSE36133. (C) The expression levels of BAIAP2L1 in cell lines of ovarian cancer (OV, n = 49) and other origins (n = 972). Data are retrieved from GSE2109.

Mentions: Data in GSE14407 data set [29] indicated that BAIAP2L1 mRNA expression was significantly higher in ovarian cancer epithelial cells (CEPI, 11.8 ± 0.28 shown as mean ± standard error) than in normal ovarian surface epithelia (OSE, 10.8 ± 0.22) (p = 0.004) (Fig 5A). In the tissue expression level, GSE36133 data set showed that BAIAP2L1 was significantly higher in 182 primary ovarian and fallopian tubal cancers (10.4 ± 0.09) compared to 1680 primary cancers mostly from breast, colon, rectum, endometrium, lung, and kidney (9.8 ± 0.04) (p = 4.5 x 10−7) (Fig 5B). GSE2109 data set [30] further revealed that BAIAP2L1 was significantly higher in 49 ovarian cancer cell lines (9.4 ± 0.17) than 972 cancer cell lines derived from other tissues (8.6 ± 0.07) (p = 0.004) (Fig 5C).


BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a Potential Biomarker in Ovarian Cancer.

Chao A, Tsai CL, Jung SM, Chuang WC, Kao C, Hsu A, Chen SH, Lin CY, Lee YC, Lee YS, Wang TH, Wang HS, Lai CH - PLoS ONE (2015)

Significantly high expression of BAIAP2L1 in ovarian cancer tissues and ovarian cancer cell lines.(A) The mRNA expression levels of BAIAP2L1 in ovarian cancer epithelial cells (CEPI) isolated from12 ovarian serous adenocarcinoma and ovarian surface epithelium (OSE) from 12 normal human ovaries. Data are retrieved from GSE14407. (B) The expression levels of BAIAP2L1 in tissues of ovarian cancer (OV, n = 182) and cancer of other primary sites (n = 1680). Data are retrieved from GSE36133. (C) The expression levels of BAIAP2L1 in cell lines of ovarian cancer (OV, n = 49) and other origins (n = 972). Data are retrieved from GSE2109.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4519316&req=5

pone.0133081.g005: Significantly high expression of BAIAP2L1 in ovarian cancer tissues and ovarian cancer cell lines.(A) The mRNA expression levels of BAIAP2L1 in ovarian cancer epithelial cells (CEPI) isolated from12 ovarian serous adenocarcinoma and ovarian surface epithelium (OSE) from 12 normal human ovaries. Data are retrieved from GSE14407. (B) The expression levels of BAIAP2L1 in tissues of ovarian cancer (OV, n = 182) and cancer of other primary sites (n = 1680). Data are retrieved from GSE36133. (C) The expression levels of BAIAP2L1 in cell lines of ovarian cancer (OV, n = 49) and other origins (n = 972). Data are retrieved from GSE2109.
Mentions: Data in GSE14407 data set [29] indicated that BAIAP2L1 mRNA expression was significantly higher in ovarian cancer epithelial cells (CEPI, 11.8 ± 0.28 shown as mean ± standard error) than in normal ovarian surface epithelia (OSE, 10.8 ± 0.22) (p = 0.004) (Fig 5A). In the tissue expression level, GSE36133 data set showed that BAIAP2L1 was significantly higher in 182 primary ovarian and fallopian tubal cancers (10.4 ± 0.09) compared to 1680 primary cancers mostly from breast, colon, rectum, endometrium, lung, and kidney (9.8 ± 0.04) (p = 4.5 x 10−7) (Fig 5B). GSE2109 data set [30] further revealed that BAIAP2L1 was significantly higher in 49 ovarian cancer cell lines (9.4 ± 0.17) than 972 cancer cell lines derived from other tissues (8.6 ± 0.07) (p = 0.004) (Fig 5C).

Bottom Line: Brain-specific angiogenesis inhibitor 1 (BAI1)-associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration.BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma.Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

ABSTRACT
Brain-specific angiogenesis inhibitor 1 (BAI1)-associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration. BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma. In this study, we report the first comprehensive study of BAIAP2L1 upregulation in human ovarian cancer. Upregulation of BAIAP2L1 in ovarian tumors was first found during RNA screening and confirmed by immunohistochemical studies on ovarian cancers and other cancer types. Significant upregulation of BAIAP2L1 in ovarian cancer was validated by analyzing multiple independent cohorts in publicly available data sets. Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors. Functional assays in ovarian cancer cells revealed that BAIAP2L1 is involved in promoting cell proliferation and avoiding apoptosis. In conclusion, results of this study not only indicate that BAIAP2L1 can be used as a biomarker for human ovarian cancer but also reveal its role in cancer biology. Further elucidation of the role of BAIAP2L1 in context of the insulin receptor signaling pathways of cancer cells is warranted for developing cancer therapeutics by targeting cancer-specific metabolism.

No MeSH data available.


Related in: MedlinePlus