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Prospectively ECG-Triggered Sequential Dual-Source Coronary CT Angiography in Patients with Atrial Fibrillation: Influence of Heart Rate on Image Quality and Evaluation of Diagnostic Accuracy.

Yang L, Xu L, Schoepf UJ, Wichmann JL, Fox MA, Yan J, Fan Z, Zhang Z - PLoS ONE (2015)

Bottom Line: No significant impact on image quality was found for mean HR (94.9 ± 21.8 bpm; r=0.034, p=0.758; F=0.413, p=0.663) or HRV (67.5 ± 22.8 bpm; r=0.097, p=0.377; F=0.111, p=0.895).Mean effective dose was 3.3 ± 1.0 mSv.Prospectively ECG-triggered sequential dual-source CCTA provides diagnostic image quality and good diagnostic accuracy for detection of coronary stenosis in AF patients without significant influence by HR or HRV.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

ABSTRACT

Objectives: To evaluate the effects of mean heart rate (HR) and heart rate variation (HRV) on image quality and diagnostic accuracy of prospectively ECG-triggered sequential dual-source coronary CT angiography (CCTA) in patients with atrial fibrillation (AF).

Methods: Eighty-five patients (49 women, 36 men; mean age 62. 1 ± 9.5 years) with persistent AF underwent prospectively ECG-triggered sequential second-generation dual-source CCTA. Tube current and voltage were adjusted according to body mass index (BMI) and iterative reconstruction was used. Image quality of coronary segments (four-point scale) and presence of significant stenosis (>50%) were evaluated. Diagnostic accuracy was analyzed in 30 of the 85 patients who underwent additional invasive coronary angiography (ICA).

Results: Only 8 of 1102 (0.7%) segments demonstrated poor image quality. No significant impact on image quality was found for mean HR (94.9 ± 21.8 bpm; r=0.034, p=0.758; F=0.413, p=0.663) or HRV (67.5 ± 22.8 bpm; r=0.097, p=0.377; F=0.111, p=0.895). On per-segment analysis, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 89.7% (26/29), 99.4% (355/357), 92.9% (26/28), and 99.2% (355/358), respectively, with excellent correlation (kappa=0.91) with ICA. Mean effective dose was 3.3 ± 1.0 mSv.

Conclusions: Prospectively ECG-triggered sequential dual-source CCTA provides diagnostic image quality and good diagnostic accuracy for detection of coronary stenosis in AF patients without significant influence by HR or HRV.

No MeSH data available.


Related in: MedlinePlus

The Linear regression analysis of image quality versus HR.No significant linear correlation between image quality and mean HR in AF patients by using prospectively ECG-triggered dual-source CT (Pearson correlation, r = 0.034, P = 0.758).
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pone.0134194.g001: The Linear regression analysis of image quality versus HR.No significant linear correlation between image quality and mean HR in AF patients by using prospectively ECG-triggered dual-source CT (Pearson correlation, r = 0.034, P = 0.758).

Mentions: No significant correlation was observed between mean HR and mean image quality scores for all coronary segments in each patient (P>0.05) (Fig 1) or for each branch of coronary artery (P>0.05) (Table 3). Similarly, there was no significant correlation between HRV during CCTA and mean image quality scores for all coronary segments (P>0.05) and branches (Fig 2).


Prospectively ECG-Triggered Sequential Dual-Source Coronary CT Angiography in Patients with Atrial Fibrillation: Influence of Heart Rate on Image Quality and Evaluation of Diagnostic Accuracy.

Yang L, Xu L, Schoepf UJ, Wichmann JL, Fox MA, Yan J, Fan Z, Zhang Z - PLoS ONE (2015)

The Linear regression analysis of image quality versus HR.No significant linear correlation between image quality and mean HR in AF patients by using prospectively ECG-triggered dual-source CT (Pearson correlation, r = 0.034, P = 0.758).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4519310&req=5

pone.0134194.g001: The Linear regression analysis of image quality versus HR.No significant linear correlation between image quality and mean HR in AF patients by using prospectively ECG-triggered dual-source CT (Pearson correlation, r = 0.034, P = 0.758).
Mentions: No significant correlation was observed between mean HR and mean image quality scores for all coronary segments in each patient (P>0.05) (Fig 1) or for each branch of coronary artery (P>0.05) (Table 3). Similarly, there was no significant correlation between HRV during CCTA and mean image quality scores for all coronary segments (P>0.05) and branches (Fig 2).

Bottom Line: No significant impact on image quality was found for mean HR (94.9 ± 21.8 bpm; r=0.034, p=0.758; F=0.413, p=0.663) or HRV (67.5 ± 22.8 bpm; r=0.097, p=0.377; F=0.111, p=0.895).Mean effective dose was 3.3 ± 1.0 mSv.Prospectively ECG-triggered sequential dual-source CCTA provides diagnostic image quality and good diagnostic accuracy for detection of coronary stenosis in AF patients without significant influence by HR or HRV.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

ABSTRACT

Objectives: To evaluate the effects of mean heart rate (HR) and heart rate variation (HRV) on image quality and diagnostic accuracy of prospectively ECG-triggered sequential dual-source coronary CT angiography (CCTA) in patients with atrial fibrillation (AF).

Methods: Eighty-five patients (49 women, 36 men; mean age 62. 1 ± 9.5 years) with persistent AF underwent prospectively ECG-triggered sequential second-generation dual-source CCTA. Tube current and voltage were adjusted according to body mass index (BMI) and iterative reconstruction was used. Image quality of coronary segments (four-point scale) and presence of significant stenosis (>50%) were evaluated. Diagnostic accuracy was analyzed in 30 of the 85 patients who underwent additional invasive coronary angiography (ICA).

Results: Only 8 of 1102 (0.7%) segments demonstrated poor image quality. No significant impact on image quality was found for mean HR (94.9 ± 21.8 bpm; r=0.034, p=0.758; F=0.413, p=0.663) or HRV (67.5 ± 22.8 bpm; r=0.097, p=0.377; F=0.111, p=0.895). On per-segment analysis, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 89.7% (26/29), 99.4% (355/357), 92.9% (26/28), and 99.2% (355/358), respectively, with excellent correlation (kappa=0.91) with ICA. Mean effective dose was 3.3 ± 1.0 mSv.

Conclusions: Prospectively ECG-triggered sequential dual-source CCTA provides diagnostic image quality and good diagnostic accuracy for detection of coronary stenosis in AF patients without significant influence by HR or HRV.

No MeSH data available.


Related in: MedlinePlus