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Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

Dan X, King BR, Doyon J, Chan P - PLoS ONE (2015)

Bottom Line: LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest.Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand.Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

No MeSH data available.


Related in: MedlinePlus

The number of correct sequences in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD.
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pone.0134291.g003: The number of correct sequences in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD.

Mentions: The number of correct sequences completed in the initial learning session is depicted in Fig 3A. The 3 (Group) x 14 (Block) ANCOVA indicated a significant Block main effect (F(13,884) = 8.08; p<0.001), as movement accuracy was modulated by practice. Results also revealed a significant Group main effect (F(2,67) = 4.28; p = 0.018) and subsequent analyses indicated that the healthy controls were more accurate relative to the LH-A (F(1,50) = 6.34; p = 0.015) and LH-S patients (F(1,44) = 8.33; p = 0.006). Similar to the analysis of movement speed above, the Block x Group interaction was not significant (F(26,884) = 1.18; p = 0.25).


Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

Dan X, King BR, Doyon J, Chan P - PLoS ONE (2015)

The number of correct sequences in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4519305&req=5

pone.0134291.g003: The number of correct sequences in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD.
Mentions: The number of correct sequences completed in the initial learning session is depicted in Fig 3A. The 3 (Group) x 14 (Block) ANCOVA indicated a significant Block main effect (F(13,884) = 8.08; p<0.001), as movement accuracy was modulated by practice. Results also revealed a significant Group main effect (F(2,67) = 4.28; p = 0.018) and subsequent analyses indicated that the healthy controls were more accurate relative to the LH-A (F(1,50) = 6.34; p = 0.015) and LH-S patients (F(1,44) = 8.33; p = 0.006). Similar to the analysis of movement speed above, the Block x Group interaction was not significant (F(26,884) = 1.18; p = 0.25).

Bottom Line: LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest.Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand.Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

No MeSH data available.


Related in: MedlinePlus