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Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

Dan X, King BR, Doyon J, Chan P - PLoS ONE (2015)

Bottom Line: LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest.Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand.Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

No MeSH data available.


Related in: MedlinePlus

Block Duration in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD. Thick solid lines represent group-averaged trajectories based on a single exponential fit.
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pone.0134291.g002: Block Duration in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD. Thick solid lines represent group-averaged trajectories based on a single exponential fit.

Mentions: Block Duration for the initial learning session is depicted in Fig 2A. A 3 (Group) x 14 (Block) ANCOVA with age as the covariate revealed a significant Block main effect (F(13,884) = 63.31; p<0.001) as the time to complete a block of practice decreased as a function of training. There was also a significant Group main effect (F(2,67) = 3.90; p = 0.025). Follow-up analyses indicated that the LH-S patients with PD were significantly slower relative to the healthy controls (F(1,44) = 11.08; p = 0.002). The Block x Group interaction was not significant (F(26,884) = 0.51; p = 0.98), indicating that the rate of change in movement speed did not differ among the three groups in the initial learning session (although see analyses of Performance Index below).


Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

Dan X, King BR, Doyon J, Chan P - PLoS ONE (2015)

Block Duration in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD. Thick solid lines represent group-averaged trajectories based on a single exponential fit.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4519305&req=5

pone.0134291.g002: Block Duration in Session 1 (A) and Session 2 (B).Data points represent group means for each block and error bars depict standard errors. Black squares = healthy controls; blue circles = left hand asymptomatic (LH-A) patients with PD; red crosses = left hand symptomatic patients (LH-S) with PD. Thick solid lines represent group-averaged trajectories based on a single exponential fit.
Mentions: Block Duration for the initial learning session is depicted in Fig 2A. A 3 (Group) x 14 (Block) ANCOVA with age as the covariate revealed a significant Block main effect (F(13,884) = 63.31; p<0.001) as the time to complete a block of practice decreased as a function of training. There was also a significant Group main effect (F(2,67) = 3.90; p = 0.025). Follow-up analyses indicated that the LH-S patients with PD were significantly slower relative to the healthy controls (F(1,44) = 11.08; p = 0.002). The Block x Group interaction was not significant (F(26,884) = 0.51; p = 0.98), indicating that the rate of change in movement speed did not differ among the three groups in the initial learning session (although see analyses of Performance Index below).

Bottom Line: LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest.Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand.Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurobiology and Neurology, Key Laboratory of Ministry of Education on Neurodegenerative Disorders, Beijing Key Laboratory on Parkinson's Disease, Xuanwu Hospital of Capital Medical University, Beijing, China.

ABSTRACT
Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymptomatic, LH-A) patients served to investigate whether MSL impairments appear before symptoms in the tested hand. LH-S patients demonstrated impaired learning during the initial training session and both LH-S and LH-A patients demonstrated decreased performance compared to controls during the next-day retest. Critically, the impairments in later learning stages in the LH-A patients were evident even before the appearance of traditional clinical symptoms in the tested hand. Results may be explained by the progression of disease-related alterations in relevant corticostriatal networks.

No MeSH data available.


Related in: MedlinePlus