High-Resolution Imaging of the Optic Nerve and Retina in Optic Nerve Hypoplasia.
Bottom Line: Patients with ONH had significantly smaller discs (P < 0.03 and P < 0.001 compared with unaffected eye and healthy controls, respectively), horizontal cup diameter (P < 0.02 for both), and cup depth (P < 0.02 and P < 0.01, respectively).In the macula, significantly thinner RNFL (nasally), ganglion cell layer (GCL) (nasally and temporally), inner plexiform layer (IPL) (nasally), outer nuclear layer (ONL) (nasally), and inner segment (centrally and temporally) were found in patients with ONH compared with the control group (P < 0.05 for all comparisons).Continuation of significantly thicker GCL, IPL, and outer plexiform layer in the central retinal area (i.e., foveal hypoplasia) was found in more than 80% of patients with ONH.
Affiliation: Ophthalmology Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom.Show MeSH
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Mentions: Peripapillary RNFL was significantly thinner in the affected eye of patients with ONH compared with controls, with similar differences being observed in both nasal and temporal RNFL (54% and 68% of control values, respectively) (Fig 6). The RNFL thicknesses for the clinically unaffected eyes of patients with ONH were approximately midway between thicknesses in affected eyes of patients with ONH and controls. We found no significant difference in peripapillary RNFL between the 2 eyes in patients with bilaterally hypoplastic discs for any optic disc parameter.
Affiliation: Ophthalmology Group, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom.