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Brewers' Rice: A By-Product from Rice Processing Provides Natural Hepatorenal Protection in Azoxymethane-Induced Oxidative Stress in Rats.

Tan BL, Norhaizan ME, Hairuszah I, Hazilawati H, Roselina K - Oxid Med Cell Longev (2015)

Bottom Line: Brewers' rice, which is known locally as temukut, is a mixture of broken rice, rice bran, and rice germ.Overall analyses revealed that brewers' rice improved the levels of serum markers in a manner associated with better histopathological outcomes, which indicated that brewers' rice could enhance recovery from hepatocyte and kidney damage.Taken together, these results suggest that brewers' rice could be used in future applications to combat liver and kidney disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

ABSTRACT
Brewers' rice, which is known locally as temukut, is a mixture of broken rice, rice bran, and rice germ. Our present study was designed to identify the effect of brewers' rice on the attenuation of liver and kidney damage induced by azoxymethane (AOM). Alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST), creatinine, and urea were evaluated to understand potential hepatoprotective effects and the ability of brewers' rice to attenuate kidney pathology induced by AOM treatment. Liver and kidney tissues were evaluated by hematoxylin and eosin (H&E) staining. Overall analyses revealed that brewers' rice improved the levels of serum markers in a manner associated with better histopathological outcomes, which indicated that brewers' rice could enhance recovery from hepatocyte and kidney damage. Taken together, these results suggest that brewers' rice could be used in future applications to combat liver and kidney disease.

No MeSH data available.


Related in: MedlinePlus

Relative organ weight of rats. (a) After eight-week treatment with brewers' rice. (b) After twenty-week treatment with brewers' rice. Value with different superscript letter indicates significant difference between groups by Tukey's test (P < 0.05).
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fig2: Relative organ weight of rats. (a) After eight-week treatment with brewers' rice. (b) After twenty-week treatment with brewers' rice. Value with different superscript letter indicates significant difference between groups by Tukey's test (P < 0.05).

Mentions: Organ weights were measured for all groups and expressed as relative organ weights [16]. As shown in Figures 2(a) and 2(b), the final relative heart, lung, liver, kidney, and spleen weights were measured at the termination of the study (after eight and twenty weeks of treatment with brewers' rice). After eight weeks of treatment with brewers' rice, no significant difference was found in the relative heart, lung, kidney, and spleen weights among the normal, AOM only, or brewers' rice groups (P > 0.05). However, a significant increase in relative liver weight was observed in the AOM-only group and two treatment groups (10% and 40% (w/w) of brewers' rice) compared to that observed in the normal group (P < 0.05) (Figure 2(a)). Relative organ weight depends on the organ weight and body weight of individual rat. Even though an earlier study demonstrated that AOM causes hepatotoxicity in various experimental animal studies [3] and is responsible for most of the damage in the liver [4] during the induction of colon cancer, which could reduce the body weight of rats. However, in the present study, the increase of relative liver weight in AOM-only group and those groups fed with diets containing 10% (w/w) brewers' rice and 40% (w/w) of brewers' rice may reveal that the study duration was too short to observe the previously shown effects. The relative heart, lung, liver, kidney, and spleen weights for all brewers' rice-fed groups were nearly similar to those of the normal group and did not show any significant differences after twenty weeks of treatment with brewers' rice (P > 0.05) (Figure 2(b)). The absence of significant differences in relative organ weight after twenty weeks of treatment with brewers' rice implied that dietary intake had no apparent influence on the findings.


Brewers' Rice: A By-Product from Rice Processing Provides Natural Hepatorenal Protection in Azoxymethane-Induced Oxidative Stress in Rats.

Tan BL, Norhaizan ME, Hairuszah I, Hazilawati H, Roselina K - Oxid Med Cell Longev (2015)

Relative organ weight of rats. (a) After eight-week treatment with brewers' rice. (b) After twenty-week treatment with brewers' rice. Value with different superscript letter indicates significant difference between groups by Tukey's test (P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4516842&req=5

fig2: Relative organ weight of rats. (a) After eight-week treatment with brewers' rice. (b) After twenty-week treatment with brewers' rice. Value with different superscript letter indicates significant difference between groups by Tukey's test (P < 0.05).
Mentions: Organ weights were measured for all groups and expressed as relative organ weights [16]. As shown in Figures 2(a) and 2(b), the final relative heart, lung, liver, kidney, and spleen weights were measured at the termination of the study (after eight and twenty weeks of treatment with brewers' rice). After eight weeks of treatment with brewers' rice, no significant difference was found in the relative heart, lung, kidney, and spleen weights among the normal, AOM only, or brewers' rice groups (P > 0.05). However, a significant increase in relative liver weight was observed in the AOM-only group and two treatment groups (10% and 40% (w/w) of brewers' rice) compared to that observed in the normal group (P < 0.05) (Figure 2(a)). Relative organ weight depends on the organ weight and body weight of individual rat. Even though an earlier study demonstrated that AOM causes hepatotoxicity in various experimental animal studies [3] and is responsible for most of the damage in the liver [4] during the induction of colon cancer, which could reduce the body weight of rats. However, in the present study, the increase of relative liver weight in AOM-only group and those groups fed with diets containing 10% (w/w) brewers' rice and 40% (w/w) of brewers' rice may reveal that the study duration was too short to observe the previously shown effects. The relative heart, lung, liver, kidney, and spleen weights for all brewers' rice-fed groups were nearly similar to those of the normal group and did not show any significant differences after twenty weeks of treatment with brewers' rice (P > 0.05) (Figure 2(b)). The absence of significant differences in relative organ weight after twenty weeks of treatment with brewers' rice implied that dietary intake had no apparent influence on the findings.

Bottom Line: Brewers' rice, which is known locally as temukut, is a mixture of broken rice, rice bran, and rice germ.Overall analyses revealed that brewers' rice improved the levels of serum markers in a manner associated with better histopathological outcomes, which indicated that brewers' rice could enhance recovery from hepatocyte and kidney damage.Taken together, these results suggest that brewers' rice could be used in future applications to combat liver and kidney disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

ABSTRACT
Brewers' rice, which is known locally as temukut, is a mixture of broken rice, rice bran, and rice germ. Our present study was designed to identify the effect of brewers' rice on the attenuation of liver and kidney damage induced by azoxymethane (AOM). Alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST), creatinine, and urea were evaluated to understand potential hepatoprotective effects and the ability of brewers' rice to attenuate kidney pathology induced by AOM treatment. Liver and kidney tissues were evaluated by hematoxylin and eosin (H&E) staining. Overall analyses revealed that brewers' rice improved the levels of serum markers in a manner associated with better histopathological outcomes, which indicated that brewers' rice could enhance recovery from hepatocyte and kidney damage. Taken together, these results suggest that brewers' rice could be used in future applications to combat liver and kidney disease.

No MeSH data available.


Related in: MedlinePlus