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Biomimetism, biomimetic matrices and the induction of bone formation.

Ripamonti U - J. Cell. Mol. Med. (2008)

Bottom Line: Influence of geometry on the expression of the osteogenic phenotype.A most exciting and novel strategy to initiate bone formation by induction is to carve smart self-inducing geometric concavities assembled within biomimetic constructs.This manuscript reviews the available data on this fascinating phenomenon, i.e. biomimetic matrices that arouse and set into motion the mammalian natural ability to heal thus constructing biomimetic matrices that in their own right set into motion inductive regenerative phenomena initiating the cascade of bone differentiation by induction biomimetizing the remodelling cycle of the primate cortico-cancellous bone.

View Article: PubMed Central - PubMed

Affiliation: Bone Research Unit, Medical Research Council/University of the Witwatersrand, Johannesburg, South Africa. ugo.ripamonti@wits.ac.za

ABSTRACT

Introduction: the induction of bone formation, the emergence of the skeleton, of the vertebrates and of Homo species * Different strategies for the induction of bone formation. Biological significance of redundancy and synergistic induction of bone formation. Biomimetism and biomimetic matrices self-assembling the induction of bone formation The concavity: the shape of life and the induction of bone formation. Influence of geometry on the expression of the osteogenic phenotype. Conclusion and therapeutic perspectives on porous biomimetic matrices with intrinsic osteoinductivity Bone formation by induction initiates by invocation of osteogenic soluble molecular signals of the transforming growth factor-beta (TGF-beta) superfamily; when combined with insoluble signals or substrata, the osteogenic soluble signals trigger the ripple-like cascade of cell differentiation into osteoblastic cell lines secreting bone matrix at site of surgical implantation. A most exciting and novel strategy to initiate bone formation by induction is to carve smart self-inducing geometric concavities assembled within biomimetic constructs. The assembly of a series of repetitive concavities within the biomimetic constructs is endowed with the striking prerogative of differentiating osteoblast-like cells attached to the biomimetic matrices initiating the induction of bone formation as a secondary response. Importantly, the induction of bone formation is initiated without the exogenous application of the osteogenic soluble molecular signals of the TGF-beta superfamily. This manuscript reviews the available data on this fascinating phenomenon, i.e. biomimetic matrices that arouse and set into motion the mammalian natural ability to heal thus constructing biomimetic matrices that in their own right set into motion inductive regenerative phenomena initiating the cascade of bone differentiation by induction biomimetizing the remodelling cycle of the primate cortico-cancellous bone.

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Substantial bone morphogenesis by induction in porous coral-derived hydroxyapatites long-term implanted in the rectus abdominis muscle of adult baboons Papio ursinus. (A and C) Low- and high-power views of bone induction within the implanted biomimetic matrix harvested 6 month after implantation in the rectus abdominis muscle of adult baboon. (B and D) Morphogenesis of bone in coral derived porous hydroxyapatites harvested 9 months after implantation. Lamellar/osteonic bone with bone marrow. Original magnification: (A) ×125; (B) ×125; (C) ×175; (D) ×175; (E) ×275; (F) ×275.
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fig06: Substantial bone morphogenesis by induction in porous coral-derived hydroxyapatites long-term implanted in the rectus abdominis muscle of adult baboons Papio ursinus. (A and C) Low- and high-power views of bone induction within the implanted biomimetic matrix harvested 6 month after implantation in the rectus abdominis muscle of adult baboon. (B and D) Morphogenesis of bone in coral derived porous hydroxyapatites harvested 9 months after implantation. Lamellar/osteonic bone with bone marrow. Original magnification: (A) ×125; (B) ×125; (C) ×175; (D) ×175; (E) ×275; (F) ×275.

Mentions: The intrinsic or spontaneous induction of bone formation in a variety of porous biomaterials is a very interesting phenomenon which originally has been shown by implanting porous polyhydroxyethyl-methacrylate in the sub-cutis of white pigs [99]. In the late 1980s, systematic studies were started in non-human primates Papio ursinus after the remarkable finding of intrinsic osteoinductivity in the porous spaces of coral-derived HAs (Figs. 4–6) [5, 54, 96, 97, 100, 101]. Coral-derived HAs induced substantial amounts of membranous bone when implanted heterotopically in the rectus abdominis muscle of adult Papio ursinus (Figs. 5 and 6) [54, 96, 97, 100, 101]. In the same animals, coral-derived (Figs 8 and 9) and sintered porous HAs (Fig. 10) implanted in calvarial defects also induced extensive bone deposition culminating in complete calvarial regeneration [5, 7, 55, 101].


Biomimetism, biomimetic matrices and the induction of bone formation.

Ripamonti U - J. Cell. Mol. Med. (2008)

Substantial bone morphogenesis by induction in porous coral-derived hydroxyapatites long-term implanted in the rectus abdominis muscle of adult baboons Papio ursinus. (A and C) Low- and high-power views of bone induction within the implanted biomimetic matrix harvested 6 month after implantation in the rectus abdominis muscle of adult baboon. (B and D) Morphogenesis of bone in coral derived porous hydroxyapatites harvested 9 months after implantation. Lamellar/osteonic bone with bone marrow. Original magnification: (A) ×125; (B) ×125; (C) ×175; (D) ×175; (E) ×275; (F) ×275.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4516458&req=5

fig06: Substantial bone morphogenesis by induction in porous coral-derived hydroxyapatites long-term implanted in the rectus abdominis muscle of adult baboons Papio ursinus. (A and C) Low- and high-power views of bone induction within the implanted biomimetic matrix harvested 6 month after implantation in the rectus abdominis muscle of adult baboon. (B and D) Morphogenesis of bone in coral derived porous hydroxyapatites harvested 9 months after implantation. Lamellar/osteonic bone with bone marrow. Original magnification: (A) ×125; (B) ×125; (C) ×175; (D) ×175; (E) ×275; (F) ×275.
Mentions: The intrinsic or spontaneous induction of bone formation in a variety of porous biomaterials is a very interesting phenomenon which originally has been shown by implanting porous polyhydroxyethyl-methacrylate in the sub-cutis of white pigs [99]. In the late 1980s, systematic studies were started in non-human primates Papio ursinus after the remarkable finding of intrinsic osteoinductivity in the porous spaces of coral-derived HAs (Figs. 4–6) [5, 54, 96, 97, 100, 101]. Coral-derived HAs induced substantial amounts of membranous bone when implanted heterotopically in the rectus abdominis muscle of adult Papio ursinus (Figs. 5 and 6) [54, 96, 97, 100, 101]. In the same animals, coral-derived (Figs 8 and 9) and sintered porous HAs (Fig. 10) implanted in calvarial defects also induced extensive bone deposition culminating in complete calvarial regeneration [5, 7, 55, 101].

Bottom Line: Influence of geometry on the expression of the osteogenic phenotype.A most exciting and novel strategy to initiate bone formation by induction is to carve smart self-inducing geometric concavities assembled within biomimetic constructs.This manuscript reviews the available data on this fascinating phenomenon, i.e. biomimetic matrices that arouse and set into motion the mammalian natural ability to heal thus constructing biomimetic matrices that in their own right set into motion inductive regenerative phenomena initiating the cascade of bone differentiation by induction biomimetizing the remodelling cycle of the primate cortico-cancellous bone.

View Article: PubMed Central - PubMed

Affiliation: Bone Research Unit, Medical Research Council/University of the Witwatersrand, Johannesburg, South Africa. ugo.ripamonti@wits.ac.za

ABSTRACT

Introduction: the induction of bone formation, the emergence of the skeleton, of the vertebrates and of Homo species * Different strategies for the induction of bone formation. Biological significance of redundancy and synergistic induction of bone formation. Biomimetism and biomimetic matrices self-assembling the induction of bone formation The concavity: the shape of life and the induction of bone formation. Influence of geometry on the expression of the osteogenic phenotype. Conclusion and therapeutic perspectives on porous biomimetic matrices with intrinsic osteoinductivity Bone formation by induction initiates by invocation of osteogenic soluble molecular signals of the transforming growth factor-beta (TGF-beta) superfamily; when combined with insoluble signals or substrata, the osteogenic soluble signals trigger the ripple-like cascade of cell differentiation into osteoblastic cell lines secreting bone matrix at site of surgical implantation. A most exciting and novel strategy to initiate bone formation by induction is to carve smart self-inducing geometric concavities assembled within biomimetic constructs. The assembly of a series of repetitive concavities within the biomimetic constructs is endowed with the striking prerogative of differentiating osteoblast-like cells attached to the biomimetic matrices initiating the induction of bone formation as a secondary response. Importantly, the induction of bone formation is initiated without the exogenous application of the osteogenic soluble molecular signals of the TGF-beta superfamily. This manuscript reviews the available data on this fascinating phenomenon, i.e. biomimetic matrices that arouse and set into motion the mammalian natural ability to heal thus constructing biomimetic matrices that in their own right set into motion inductive regenerative phenomena initiating the cascade of bone differentiation by induction biomimetizing the remodelling cycle of the primate cortico-cancellous bone.

Show MeSH
Related in: MedlinePlus