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[Noncirrhotic portal hypertension in a human immunodeficiency virus (HIV) infected adolescent].

Gouvêa Ade F, Machado DM, Beltrão SC, Carmo FB, Mattar RH, Succi RC - Rev Paul Pediatr (2015)

Bottom Line: Although the HIV viral load had been undetectable for 12 years, this patient showed gradual decrease of CD4+ T cells, prolonged thrombocytopenia and high alkaline phosphatase.Physical examination detected splenomegaly, which triggered the investigation that led to the diagnosis of severe liver fibrosis by transient elastography, probably due to hepatic toxicity by prolonged use of ddI.This is the first case of NCPH in HIV-infected adolescent described in Brazil.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil. Electronic address: aidagouvea@uol.com.br.

No MeSH data available.


Related in: MedlinePlus

Abdominal computed tomography, showing homogeneous hepatosplenomegaly,exerting posterior compression on the kidneys. São Paulo, SP, Brazil, 2014. Thearrows indicate the compression of the kidneys bilaterally by hepatomegaly (R)and splenomegaly (L).
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f01: Abdominal computed tomography, showing homogeneous hepatosplenomegaly,exerting posterior compression on the kidneys. São Paulo, SP, Brazil, 2014. Thearrows indicate the compression of the kidneys bilaterally by hepatomegaly (R)and splenomegaly (L).

Mentions: Infectious and oncological causes were investigated and ruled out for theimmunosuppression and hepatosplenomegaly: immunity for CMV, hepatitis A and hepatitis B,negative serology for hepatitis C, toxoplasmosis and mononucleosis. The abdominalultrasound confirmed splenomegaly; CT of the chest and abdomen showed normal chest,homogeneous hepatosplenomegaly, compressing the kidneys posteriorly, and increasedportal vein dimensions (1.8 cm) (Fig. 1).


[Noncirrhotic portal hypertension in a human immunodeficiency virus (HIV) infected adolescent].

Gouvêa Ade F, Machado DM, Beltrão SC, Carmo FB, Mattar RH, Succi RC - Rev Paul Pediatr (2015)

Abdominal computed tomography, showing homogeneous hepatosplenomegaly,exerting posterior compression on the kidneys. São Paulo, SP, Brazil, 2014. Thearrows indicate the compression of the kidneys bilaterally by hepatomegaly (R)and splenomegaly (L).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4516380&req=5

f01: Abdominal computed tomography, showing homogeneous hepatosplenomegaly,exerting posterior compression on the kidneys. São Paulo, SP, Brazil, 2014. Thearrows indicate the compression of the kidneys bilaterally by hepatomegaly (R)and splenomegaly (L).
Mentions: Infectious and oncological causes were investigated and ruled out for theimmunosuppression and hepatosplenomegaly: immunity for CMV, hepatitis A and hepatitis B,negative serology for hepatitis C, toxoplasmosis and mononucleosis. The abdominalultrasound confirmed splenomegaly; CT of the chest and abdomen showed normal chest,homogeneous hepatosplenomegaly, compressing the kidneys posteriorly, and increasedportal vein dimensions (1.8 cm) (Fig. 1).

Bottom Line: Although the HIV viral load had been undetectable for 12 years, this patient showed gradual decrease of CD4+ T cells, prolonged thrombocytopenia and high alkaline phosphatase.Physical examination detected splenomegaly, which triggered the investigation that led to the diagnosis of severe liver fibrosis by transient elastography, probably due to hepatic toxicity by prolonged use of ddI.This is the first case of NCPH in HIV-infected adolescent described in Brazil.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil. Electronic address: aidagouvea@uol.com.br.

No MeSH data available.


Related in: MedlinePlus