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Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis.

Miao S, Zhou SY, Han CS, Zhang LN, Sun HB, Yang B - Drug Des Devel Ther (2015)

Bottom Line: Summary odds ratios (ORs) were pooled in accordance with the random-effect model.Results revealed that increased MMP-7 expression in EC patients was positively correlated to TNM stage III-IV (OR 3.04, 95% confidence interval [CI] 1.43-6.46; P=0.004).Country-stratified analysis yielded significant association of elevated MMP-7 expression with EC in the People's Republic of China (PRC) under both TNM III-IV versus I-II and differentiation low versus high comparisons (TNM stage, OR 2.01, 95% CI 1.55-2.59, P<0.001; differentiation grade, OR 1.32, 95% CI 1.11-1.57, P=0.002).

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

ABSTRACT

Background: The MMP-7 basement membrane and extracellular matrix may be essential for tumor invasion and metastasis, and the results presented herein showed a relationship between MMP-7 expression and esophageal cancer (EC). However, its clinicopathological value for EC patients remains inconsistent. To clarify their associations, a meta-analysis of the relevant published literature was conducted.

Materials and methods: Databases including PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, and Google Scholar were electronically searched. Only those studies analyzing MMP-7 expression in EC patients with regard to series of different demographic variables and clinicopathological stages (TNM stage, differentiation and invasion grade, and lymph-node [LN] metastasis) were eligible for inclusion. Summary odds ratios (ORs) were pooled in accordance with the random-effect model.

Results: Fourteen clinical cohort studies (tumor samples =935) were incorporated into the current meta-analysis. Results revealed that increased MMP-7 expression in EC patients was positively correlated to TNM stage III-IV (OR 3.04, 95% confidence interval [CI] 1.43-6.46; P=0.004). Similar connections were also detected in the differentiation grade, invasion grade, and LN metastasis (all P<0.05). Country-stratified analysis yielded significant association of elevated MMP-7 expression with EC in the People's Republic of China (PRC) under both TNM III-IV versus I-II and differentiation low versus high comparisons (TNM stage, OR 2.01, 95% CI 1.55-2.59, P<0.001; differentiation grade, OR 1.32, 95% CI 1.11-1.57, P=0.002). With regard to invasion grade and LN metastasis, significant association was observed in all the experimental subgroups (all P-values [PRC and Japan] were lower than 0.05).

Conclusion: These data showed an obvious connection between MMP-7 and TNM stages, differentiation grade, invasive grade, and LN metastasis of EC, indicating that overexpression of MMP-7 may be a suitable diagnostic biomarker for variation in EC clinicopathological features.

No MeSH data available.


Related in: MedlinePlus

Funnel plot of publication biases on the associations between MMP-7 protein expression and the clinicopathological characteristics of esophageal cancer patients.Abbreviations: OR, odds ratio; SE, standard error; LN, lymph node.
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f6-dddt-9-3729: Funnel plot of publication biases on the associations between MMP-7 protein expression and the clinicopathological characteristics of esophageal cancer patients.Abbreviations: OR, odds ratio; SE, standard error; LN, lymph node.

Mentions: A leave-one-out sensitivity analysis was carried out to evaluate whether the present meta-analysis was stable. Each study enrolled in our meta-analysis was evaluated one by one to reflect the significance of pooled ORs. The overall statistical significance did not change when any single study was omitted. Therefore, the current meta-analysis data are relatively stable and credible (Figure 5). The funnel plots of those 14 studies were symmetrical, and Egger’s test showed no publication bias (all P>0.05, Figure 6).


Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis.

Miao S, Zhou SY, Han CS, Zhang LN, Sun HB, Yang B - Drug Des Devel Ther (2015)

Funnel plot of publication biases on the associations between MMP-7 protein expression and the clinicopathological characteristics of esophageal cancer patients.Abbreviations: OR, odds ratio; SE, standard error; LN, lymph node.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4516179&req=5

f6-dddt-9-3729: Funnel plot of publication biases on the associations between MMP-7 protein expression and the clinicopathological characteristics of esophageal cancer patients.Abbreviations: OR, odds ratio; SE, standard error; LN, lymph node.
Mentions: A leave-one-out sensitivity analysis was carried out to evaluate whether the present meta-analysis was stable. Each study enrolled in our meta-analysis was evaluated one by one to reflect the significance of pooled ORs. The overall statistical significance did not change when any single study was omitted. Therefore, the current meta-analysis data are relatively stable and credible (Figure 5). The funnel plots of those 14 studies were symmetrical, and Egger’s test showed no publication bias (all P>0.05, Figure 6).

Bottom Line: Summary odds ratios (ORs) were pooled in accordance with the random-effect model.Results revealed that increased MMP-7 expression in EC patients was positively correlated to TNM stage III-IV (OR 3.04, 95% confidence interval [CI] 1.43-6.46; P=0.004).Country-stratified analysis yielded significant association of elevated MMP-7 expression with EC in the People's Republic of China (PRC) under both TNM III-IV versus I-II and differentiation low versus high comparisons (TNM stage, OR 2.01, 95% CI 1.55-2.59, P<0.001; differentiation grade, OR 1.32, 95% CI 1.11-1.57, P=0.002).

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatrics, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

ABSTRACT

Background: The MMP-7 basement membrane and extracellular matrix may be essential for tumor invasion and metastasis, and the results presented herein showed a relationship between MMP-7 expression and esophageal cancer (EC). However, its clinicopathological value for EC patients remains inconsistent. To clarify their associations, a meta-analysis of the relevant published literature was conducted.

Materials and methods: Databases including PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, and Google Scholar were electronically searched. Only those studies analyzing MMP-7 expression in EC patients with regard to series of different demographic variables and clinicopathological stages (TNM stage, differentiation and invasion grade, and lymph-node [LN] metastasis) were eligible for inclusion. Summary odds ratios (ORs) were pooled in accordance with the random-effect model.

Results: Fourteen clinical cohort studies (tumor samples =935) were incorporated into the current meta-analysis. Results revealed that increased MMP-7 expression in EC patients was positively correlated to TNM stage III-IV (OR 3.04, 95% confidence interval [CI] 1.43-6.46; P=0.004). Similar connections were also detected in the differentiation grade, invasion grade, and LN metastasis (all P<0.05). Country-stratified analysis yielded significant association of elevated MMP-7 expression with EC in the People's Republic of China (PRC) under both TNM III-IV versus I-II and differentiation low versus high comparisons (TNM stage, OR 2.01, 95% CI 1.55-2.59, P<0.001; differentiation grade, OR 1.32, 95% CI 1.11-1.57, P=0.002). With regard to invasion grade and LN metastasis, significant association was observed in all the experimental subgroups (all P-values [PRC and Japan] were lower than 0.05).

Conclusion: These data showed an obvious connection between MMP-7 and TNM stages, differentiation grade, invasive grade, and LN metastasis of EC, indicating that overexpression of MMP-7 may be a suitable diagnostic biomarker for variation in EC clinicopathological features.

No MeSH data available.


Related in: MedlinePlus