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Effects of Acute Ingestion of Native Banana Starch on Glycemic Response Evaluated by Continuous Glucose Monitoring in Obese and Lean Subjects.

Jiménez-Domínguez G, Ble-Castillo JL, Aparicio-Trápala MA, Juárez-Rojop IE, Tovilla-Zárate CA, Ble-Castillo DJ, García-Vázquez C, Olvera-Hernández V, Pérez-Pimienta B, Diaz-Zagoya JC, Mendez JD - Int J Environ Res Public Health (2015)

Bottom Line: Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation.Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups.In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT.

View Article: PubMed Central - PubMed

Affiliation: Endocrinology Department, General Hospital No. 46, Mexican Institute for Social Security, Villahermosa 86060, Mexico. jimenezg03@hotmail.com.

ABSTRACT
An abnormal glycemic profile, including postprandial glycemia and acute glucose spikes, precedes the onset of overt diabetes in obese subjects. Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation. In this study, we examined the effects of acute ingestion of NBS on glycemic profiles by means of continuous glucose monitoring in obese and lean subjects. In a crossover study, obese and lean subjects consumed beverages containing either 38.3 g of NBS or 38.3 g of digestible corn starch (DCS) twice daily during 4 days. On day 5, a 3-h meal tolerance test (MTT) was performed to evaluate glucose and insulin responses. After 1 week of washout period, treatments were inverted. NBS supplementation reduced the 48-h glycemia AUC in lean, obese, and in the combined group of lean and obese subjects in comparison with DCS. Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups. However, no changes were observed in glycemic variability (GV) indexes between groups. In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT. Further research to elucidate the mechanism behind these changes is required.

No MeSH data available.


Related in: MedlinePlus

Study Protocol for all participants.
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ijerph-12-07491-f001: Study Protocol for all participants.

Mentions: A randomized, crossover, single-blind controlled trial with two 5-day treatment periods and a 7-day washout was conducted. The study protocol for all participants in a 5-day treatment period is shown in Figure 1. On day 1, subjects were trained to use the monitor system and perform the calibrations. On day 2, the CGM system sensor was inserted. From days 1–4 of the treatment period, subjects were under a low-fiber diet, consumed two beverages daily, and were requested to perform daily food recording. On day 5, a 3-h MTT was carried out and the CGMS sensor was removed. After 5 days of supplementation, a 7-day washout period was performed. Supplementation assignments were then reversed for an additional 5 days of follow-up.


Effects of Acute Ingestion of Native Banana Starch on Glycemic Response Evaluated by Continuous Glucose Monitoring in Obese and Lean Subjects.

Jiménez-Domínguez G, Ble-Castillo JL, Aparicio-Trápala MA, Juárez-Rojop IE, Tovilla-Zárate CA, Ble-Castillo DJ, García-Vázquez C, Olvera-Hernández V, Pérez-Pimienta B, Diaz-Zagoya JC, Mendez JD - Int J Environ Res Public Health (2015)

Study Protocol for all participants.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4515670&req=5

ijerph-12-07491-f001: Study Protocol for all participants.
Mentions: A randomized, crossover, single-blind controlled trial with two 5-day treatment periods and a 7-day washout was conducted. The study protocol for all participants in a 5-day treatment period is shown in Figure 1. On day 1, subjects were trained to use the monitor system and perform the calibrations. On day 2, the CGM system sensor was inserted. From days 1–4 of the treatment period, subjects were under a low-fiber diet, consumed two beverages daily, and were requested to perform daily food recording. On day 5, a 3-h MTT was carried out and the CGMS sensor was removed. After 5 days of supplementation, a 7-day washout period was performed. Supplementation assignments were then reversed for an additional 5 days of follow-up.

Bottom Line: Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation.Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups.In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT.

View Article: PubMed Central - PubMed

Affiliation: Endocrinology Department, General Hospital No. 46, Mexican Institute for Social Security, Villahermosa 86060, Mexico. jimenezg03@hotmail.com.

ABSTRACT
An abnormal glycemic profile, including postprandial glycemia and acute glucose spikes, precedes the onset of overt diabetes in obese subjects. Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation. In this study, we examined the effects of acute ingestion of NBS on glycemic profiles by means of continuous glucose monitoring in obese and lean subjects. In a crossover study, obese and lean subjects consumed beverages containing either 38.3 g of NBS or 38.3 g of digestible corn starch (DCS) twice daily during 4 days. On day 5, a 3-h meal tolerance test (MTT) was performed to evaluate glucose and insulin responses. After 1 week of washout period, treatments were inverted. NBS supplementation reduced the 48-h glycemia AUC in lean, obese, and in the combined group of lean and obese subjects in comparison with DCS. Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups. However, no changes were observed in glycemic variability (GV) indexes between groups. In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT. Further research to elucidate the mechanism behind these changes is required.

No MeSH data available.


Related in: MedlinePlus