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Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Gribble GW - Mar Drugs (2015)

Bottom Line: This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years.Newly discovered examples that do not report biological activity are not included.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. gordon.w.gribble@dartmouth.edu.

ABSTRACT
This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years. Newly discovered examples that do not report biological activity are not included.

No MeSH data available.


Structures of bromophenols 538–545 from the alga Rhodomela confervoides [191].
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marinedrugs-13-04044-f104: Structures of bromophenols 538–545 from the alga Rhodomela confervoides [191].

Mentions: Like terrestrial phenolic compounds, marine phenols with antioxidant properties are well known, and several recent examples have appeared. The red alga Rhodomela confervoides from Liaoning Province, China, has afforded 19 bromophenols, six of which are new (538–543) (Figure 104) [191]. Two known examples, 544 and 545, are included because they are active in the radical scavenging assays. All 19 bromophenols were subjected to both the DPPH (1,1-diphenyl-2-picrylhydrazyl) and the ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt) free radical scavenging assays. Most of the bromophenols display more potent antioxidant activity than either BHT (butylated hydroxytoluene) or ascorbic acid. For the DPPH assay the most active compound is 539 (IC50 7.43 µM) followed by 544 > 543 > 545 > 538. In the ABTS assay 543 is the most active, followed by 544 > 545 > 541.


Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Gribble GW - Mar Drugs (2015)

Structures of bromophenols 538–545 from the alga Rhodomela confervoides [191].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4515607&req=5

marinedrugs-13-04044-f104: Structures of bromophenols 538–545 from the alga Rhodomela confervoides [191].
Mentions: Like terrestrial phenolic compounds, marine phenols with antioxidant properties are well known, and several recent examples have appeared. The red alga Rhodomela confervoides from Liaoning Province, China, has afforded 19 bromophenols, six of which are new (538–543) (Figure 104) [191]. Two known examples, 544 and 545, are included because they are active in the radical scavenging assays. All 19 bromophenols were subjected to both the DPPH (1,1-diphenyl-2-picrylhydrazyl) and the ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt) free radical scavenging assays. Most of the bromophenols display more potent antioxidant activity than either BHT (butylated hydroxytoluene) or ascorbic acid. For the DPPH assay the most active compound is 539 (IC50 7.43 µM) followed by 544 > 543 > 545 > 538. In the ABTS assay 543 is the most active, followed by 544 > 545 > 541.

Bottom Line: This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years.Newly discovered examples that do not report biological activity are not included.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. gordon.w.gribble@dartmouth.edu.

ABSTRACT
This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years. Newly discovered examples that do not report biological activity are not included.

No MeSH data available.