Limits...
Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Gribble GW - Mar Drugs (2015)

Bottom Line: This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years.Newly discovered examples that do not report biological activity are not included.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. gordon.w.gribble@dartmouth.edu.

ABSTRACT
This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years. Newly discovered examples that do not report biological activity are not included.

No MeSH data available.


Structures of gemmacolides AA–AR (417–434) from the gorgonian Dichotella gemmacea [161].
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4515607&req=5

marinedrugs-13-04044-f082: Structures of gemmacolides AA–AR (417–434) from the gorgonian Dichotella gemmacea [161].

Mentions: The earlier discussed gemmacolides and dichotellides from the gorgonian Dichotella gemmacea (Figure 1 and Figure 2) display some antitumor properties [30,31,32,33,34,161]. Against the human cancer cell lines A549 (lung adenocarcinoma) and MG63 (osteosarcoma), gemmacolides V (9) and Y (11) show IC50 values of <1.5 and <0.3 µM, respectively, against A549; and gemmacolide Y has IC50 < 0.3 µM towards MG63. The positive control adriamycin gives IC50 2.8 and 3.2 µM for these two cell lines, respectively [31]. Juncin R shows 5.6 µM towards MG63 cells [30]. Of gemmacolides G–M, only gemmacolide J shows good growth inhibition against A549 cells (IC50 < 1.4 µM) [33]. The dichotellides F–U are not cytotoxic to the human cancer cell lines SW1990, MCF-7, HepG2, and H460 cell lines, but dichotellide C displays (marginal) activity towards SW1990 (pancreatic) with IC50 45 µM (fluorouracil, IC50 121 µM) [34]. A later tour de force examination of Dichotella gemmacea revealed the presence of 18 new gemmacolides AA–AR (417–434) (Figure 82) [161]. The most cytotoxic compound in the A549 and MG63 cell line assays is gemmacolide AH (424) with IC50 for both cell types (adriamycin: IC50 2.8 and 3.2 µM).


Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Gribble GW - Mar Drugs (2015)

Structures of gemmacolides AA–AR (417–434) from the gorgonian Dichotella gemmacea [161].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4515607&req=5

marinedrugs-13-04044-f082: Structures of gemmacolides AA–AR (417–434) from the gorgonian Dichotella gemmacea [161].
Mentions: The earlier discussed gemmacolides and dichotellides from the gorgonian Dichotella gemmacea (Figure 1 and Figure 2) display some antitumor properties [30,31,32,33,34,161]. Against the human cancer cell lines A549 (lung adenocarcinoma) and MG63 (osteosarcoma), gemmacolides V (9) and Y (11) show IC50 values of <1.5 and <0.3 µM, respectively, against A549; and gemmacolide Y has IC50 < 0.3 µM towards MG63. The positive control adriamycin gives IC50 2.8 and 3.2 µM for these two cell lines, respectively [31]. Juncin R shows 5.6 µM towards MG63 cells [30]. Of gemmacolides G–M, only gemmacolide J shows good growth inhibition against A549 cells (IC50 < 1.4 µM) [33]. The dichotellides F–U are not cytotoxic to the human cancer cell lines SW1990, MCF-7, HepG2, and H460 cell lines, but dichotellide C displays (marginal) activity towards SW1990 (pancreatic) with IC50 45 µM (fluorouracil, IC50 121 µM) [34]. A later tour de force examination of Dichotella gemmacea revealed the presence of 18 new gemmacolides AA–AR (417–434) (Figure 82) [161]. The most cytotoxic compound in the A549 and MG63 cell line assays is gemmacolide AH (424) with IC50 for both cell types (adriamycin: IC50 2.8 and 3.2 µM).

Bottom Line: This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years.Newly discovered examples that do not report biological activity are not included.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. gordon.w.gribble@dartmouth.edu.

ABSTRACT
This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity-of halogenated marine natural products discovered in the past five years. Newly discovered examples that do not report biological activity are not included.

No MeSH data available.