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Genetic Susceptibility Is One of the Determinants for Severe Fever with Thrombocytopenia Syndrome Virus Infection and Fatal Outcome: An Epidemiological Investigation.

Sun J, Tang Y, Ling F, Chang Y, Ye X, Shi W, Zhang L, Chen Z, Lin H, Qiu Z, Zhang Y, Zhang R, Mao H, Chen E, Lin J, Jiang J, Xia S, Gong Z - PLoS ONE (2015)

Bottom Line: The third sister (Case C) did not live or work together with case A and B, but had ticks in her living environment.SFTSV RNA sequences were amplified from three cases were not identical, suggesting that the three sisters were most likely infected with SFTSV through tick bite rather than through person-to-person transmission of SFTSV.Seroprevalence of SFTSV IgG antibody among healthy population in the area where the patients resided was 4.05% (3/74).

View Article: PubMed Central - PubMed

Affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.

ABSTRACT
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China and case-fatality rate of SFTS is very high (approximately 10%). However, genetic susceptibility for SFTS virus (SFTSV) infection and fatal outcome of SFTSV infection in humans are unclear. In this study, we investigated the clinical, laboratory and epidemiological features of SFTS in a cluster of three sisters who died of SFTSV infection between late April and mid-May 2014. Before disease onset, two of the sisters (Case A and case B) had common exposure history for ticks by working together in a field to pick tea leaves from April 8 to April 12. The third sister (Case C) did not live or work together with case A and B, but had ticks in her living environment. SFTSV RNA sequences were amplified from three cases were not identical, suggesting that the three sisters were most likely infected with SFTSV through tick bite rather than through person-to-person transmission of SFTSV. The sequence of SFTSV from case C was identical to SFTSV sequences from 3 groups of ticks collected around the residential area of case C. Seroprevalence of SFTSV IgG antibody among healthy population in the area where the patients resided was 4.05% (3/74). The majority of SFTSV infections were mild cases and all three sisters died of SFTSV infection suggested that they were highly susceptible to SFTSV. Our findings indicated that genetic susceptibility was a risk factor for SFTSV infection and fatal outcome.

No MeSH data available.


Related in: MedlinePlus

Phylogenetic analyses of SFTSV M genomic segments identified in patients and ticks.
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pone.0132968.g002: Phylogenetic analyses of SFTSV M genomic segments identified in patients and ticks.

Mentions: SFTSV M genomic segments were detected in three groups of ticks which comprised 45 nymph ticks around the house of case C. No SFTSV M genomic segments were found in ticks from the tea garden and body surfaces of cattle in the village of case B, serum samples of 7 chickens, 6 dogs, 5 cows and 3 ducks from case C’ home. As shown in Fig 2, SFTSV M genomic segment of case C (ZJ2014P-3) were closely related to corresponding segments from the three tick groups (ZJ2014T-1, ZJ2014T-2, ZJ2014T-3) and corresponding segments from Jiangsu Province, Shandong Province, Henan Province, and Liaoning Province. SFTSV M genomic segment of case A (ZJ2014P-1) was most similar to corresponding segments from Japan and Zhoushan City which lies in the northeast of Zhejiang Province. But sequences of case A, case C, and corresponding sequences from other provinces were possessed high degrees of similarity between nucleotide (95%-99%).


Genetic Susceptibility Is One of the Determinants for Severe Fever with Thrombocytopenia Syndrome Virus Infection and Fatal Outcome: An Epidemiological Investigation.

Sun J, Tang Y, Ling F, Chang Y, Ye X, Shi W, Zhang L, Chen Z, Lin H, Qiu Z, Zhang Y, Zhang R, Mao H, Chen E, Lin J, Jiang J, Xia S, Gong Z - PLoS ONE (2015)

Phylogenetic analyses of SFTSV M genomic segments identified in patients and ticks.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4514768&req=5

pone.0132968.g002: Phylogenetic analyses of SFTSV M genomic segments identified in patients and ticks.
Mentions: SFTSV M genomic segments were detected in three groups of ticks which comprised 45 nymph ticks around the house of case C. No SFTSV M genomic segments were found in ticks from the tea garden and body surfaces of cattle in the village of case B, serum samples of 7 chickens, 6 dogs, 5 cows and 3 ducks from case C’ home. As shown in Fig 2, SFTSV M genomic segment of case C (ZJ2014P-3) were closely related to corresponding segments from the three tick groups (ZJ2014T-1, ZJ2014T-2, ZJ2014T-3) and corresponding segments from Jiangsu Province, Shandong Province, Henan Province, and Liaoning Province. SFTSV M genomic segment of case A (ZJ2014P-1) was most similar to corresponding segments from Japan and Zhoushan City which lies in the northeast of Zhejiang Province. But sequences of case A, case C, and corresponding sequences from other provinces were possessed high degrees of similarity between nucleotide (95%-99%).

Bottom Line: The third sister (Case C) did not live or work together with case A and B, but had ticks in her living environment.SFTSV RNA sequences were amplified from three cases were not identical, suggesting that the three sisters were most likely infected with SFTSV through tick bite rather than through person-to-person transmission of SFTSV.Seroprevalence of SFTSV IgG antibody among healthy population in the area where the patients resided was 4.05% (3/74).

View Article: PubMed Central - PubMed

Affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.

ABSTRACT
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China and case-fatality rate of SFTS is very high (approximately 10%). However, genetic susceptibility for SFTS virus (SFTSV) infection and fatal outcome of SFTSV infection in humans are unclear. In this study, we investigated the clinical, laboratory and epidemiological features of SFTS in a cluster of three sisters who died of SFTSV infection between late April and mid-May 2014. Before disease onset, two of the sisters (Case A and case B) had common exposure history for ticks by working together in a field to pick tea leaves from April 8 to April 12. The third sister (Case C) did not live or work together with case A and B, but had ticks in her living environment. SFTSV RNA sequences were amplified from three cases were not identical, suggesting that the three sisters were most likely infected with SFTSV through tick bite rather than through person-to-person transmission of SFTSV. The sequence of SFTSV from case C was identical to SFTSV sequences from 3 groups of ticks collected around the residential area of case C. Seroprevalence of SFTSV IgG antibody among healthy population in the area where the patients resided was 4.05% (3/74). The majority of SFTSV infections were mild cases and all three sisters died of SFTSV infection suggested that they were highly susceptible to SFTSV. Our findings indicated that genetic susceptibility was a risk factor for SFTSV infection and fatal outcome.

No MeSH data available.


Related in: MedlinePlus