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IL-2 -330T/G polymorphism and cancer risk: a meta-analysis.

Zhao H, Wang R - Onco Targets Ther (2015)

Bottom Line: The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.However, further detailed studies are still required to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.

ABSTRACT

Purpose: Some studies have investigated the association of IL-2 -330T/G (rs2069762) polymorphism with cancer risk, but the previous results were conflicting and had relatively low statistical power. Thus, we performed a meta-analysis to derive a more precise estimation of the association between IL-2 -330T/G polymorphism and cancer risk.

Methods: A literature search was performed systematically using electronic databases. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.

Results: A total of ten studies including 3,060 cases and 3,435 controls were involved in this meta-analysis. The results indicated that IL-2 -330T/G polymorphism was significantly associated with cancer risk ([OR =2.03, 95% CI =1.40-2.95] for GG vs TT; [OR =1.37, 95% CI =1.11-1.69] for GT vs TT; [OR =1.46, 95% CI =1.18-1.81] for [GG + GT] vs TT; [OR =1.66, 95% CI =1.24-2.23] for GG vs [GT + TT]; and [OR =1.35, 95% CI =1.16-1.57] for G vs T). In the subgroup analysis according to cancer type, significant association was found in lymphoma ([OR =1.46, 95% CI =1.11-1.91] for GT vs TT; [OR =1.58, 95% CI =1.22-2.05] for [GG + GT] vs TT; [OR =1.84, 95% CI =1.22-2.77] for GG vs [GT + TT]) and other cancers, but not in gastric cancer. In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.

Conclusion: This meta-analysis suggests that IL-2 -330T/G polymorphism has an increased risk of cancer in Asians. However, further detailed studies are still required to confirm our findings.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plots of IL-2 -330T/G polymorphism with overall cancer risk.Abbreviations: OR, odds ratio; SE, standard error.
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f4-ott-8-1753: Begg’s funnel plots of IL-2 -330T/G polymorphism with overall cancer risk.Abbreviations: OR, odds ratio; SE, standard error.

Mentions: As shown in Figure 3, sensitivity analysis indicated that current results were stable and credible. Publication bias was assessed by Begg’s funnel plot and Egger’s test. The shape of the Begg’s funnel plots seemed symmetrical in all genetic models, suggesting the absence of publication bias (Figure 4). Then, the Egger’s test was performed to provide statistical evidence of funnel plots symmetry. The results also indicated a lack of publication bias of the current meta-analysis (P=0.14 for GG vs TT; P=0.08 for GT vs TT; P=0.07 for [GG + GT] vs TT; P=0.17 for GG vs [GT + TT]; and P=0.11 for G vs T).


IL-2 -330T/G polymorphism and cancer risk: a meta-analysis.

Zhao H, Wang R - Onco Targets Ther (2015)

Begg’s funnel plots of IL-2 -330T/G polymorphism with overall cancer risk.Abbreviations: OR, odds ratio; SE, standard error.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4514317&req=5

f4-ott-8-1753: Begg’s funnel plots of IL-2 -330T/G polymorphism with overall cancer risk.Abbreviations: OR, odds ratio; SE, standard error.
Mentions: As shown in Figure 3, sensitivity analysis indicated that current results were stable and credible. Publication bias was assessed by Begg’s funnel plot and Egger’s test. The shape of the Begg’s funnel plots seemed symmetrical in all genetic models, suggesting the absence of publication bias (Figure 4). Then, the Egger’s test was performed to provide statistical evidence of funnel plots symmetry. The results also indicated a lack of publication bias of the current meta-analysis (P=0.14 for GG vs TT; P=0.08 for GT vs TT; P=0.07 for [GG + GT] vs TT; P=0.17 for GG vs [GT + TT]; and P=0.11 for G vs T).

Bottom Line: The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.However, further detailed studies are still required to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.

ABSTRACT

Purpose: Some studies have investigated the association of IL-2 -330T/G (rs2069762) polymorphism with cancer risk, but the previous results were conflicting and had relatively low statistical power. Thus, we performed a meta-analysis to derive a more precise estimation of the association between IL-2 -330T/G polymorphism and cancer risk.

Methods: A literature search was performed systematically using electronic databases. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.

Results: A total of ten studies including 3,060 cases and 3,435 controls were involved in this meta-analysis. The results indicated that IL-2 -330T/G polymorphism was significantly associated with cancer risk ([OR =2.03, 95% CI =1.40-2.95] for GG vs TT; [OR =1.37, 95% CI =1.11-1.69] for GT vs TT; [OR =1.46, 95% CI =1.18-1.81] for [GG + GT] vs TT; [OR =1.66, 95% CI =1.24-2.23] for GG vs [GT + TT]; and [OR =1.35, 95% CI =1.16-1.57] for G vs T). In the subgroup analysis according to cancer type, significant association was found in lymphoma ([OR =1.46, 95% CI =1.11-1.91] for GT vs TT; [OR =1.58, 95% CI =1.22-2.05] for [GG + GT] vs TT; [OR =1.84, 95% CI =1.22-2.77] for GG vs [GT + TT]) and other cancers, but not in gastric cancer. In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.

Conclusion: This meta-analysis suggests that IL-2 -330T/G polymorphism has an increased risk of cancer in Asians. However, further detailed studies are still required to confirm our findings.

No MeSH data available.


Related in: MedlinePlus