Limits...
IL-2 -330T/G polymorphism and cancer risk: a meta-analysis.

Zhao H, Wang R - Onco Targets Ther (2015)

Bottom Line: The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.However, further detailed studies are still required to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.

ABSTRACT

Purpose: Some studies have investigated the association of IL-2 -330T/G (rs2069762) polymorphism with cancer risk, but the previous results were conflicting and had relatively low statistical power. Thus, we performed a meta-analysis to derive a more precise estimation of the association between IL-2 -330T/G polymorphism and cancer risk.

Methods: A literature search was performed systematically using electronic databases. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.

Results: A total of ten studies including 3,060 cases and 3,435 controls were involved in this meta-analysis. The results indicated that IL-2 -330T/G polymorphism was significantly associated with cancer risk ([OR =2.03, 95% CI =1.40-2.95] for GG vs TT; [OR =1.37, 95% CI =1.11-1.69] for GT vs TT; [OR =1.46, 95% CI =1.18-1.81] for [GG + GT] vs TT; [OR =1.66, 95% CI =1.24-2.23] for GG vs [GT + TT]; and [OR =1.35, 95% CI =1.16-1.57] for G vs T). In the subgroup analysis according to cancer type, significant association was found in lymphoma ([OR =1.46, 95% CI =1.11-1.91] for GT vs TT; [OR =1.58, 95% CI =1.22-2.05] for [GG + GT] vs TT; [OR =1.84, 95% CI =1.22-2.77] for GG vs [GT + TT]) and other cancers, but not in gastric cancer. In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.

Conclusion: This meta-analysis suggests that IL-2 -330T/G polymorphism has an increased risk of cancer in Asians. However, further detailed studies are still required to confirm our findings.

No MeSH data available.


Related in: MedlinePlus

The flow chart of article selection.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4514317&req=5

f1-ott-8-1753: The flow chart of article selection.

Mentions: The flow chart of article selection was presented in Figure 1. A total of 94 literatures were identified through PubMed, Embase, Chinese National Knowledge Infrastructure, and Wang Fang databases. After reviewing the titles and abstracts of the potential available articles, 76 records were excluded mainly because they were of no relevance, were in vitro experiments or were reviews. From the remaining 18 articles, we eliminated five publications due to their nonrelation with IL-2 -330T/G polymorphism, and three publications due to their insufficient genotype data. Finally, ten articles, including ten studies with 3,060 cases and 3,435 controls, were included in this meta-analysis.


IL-2 -330T/G polymorphism and cancer risk: a meta-analysis.

Zhao H, Wang R - Onco Targets Ther (2015)

The flow chart of article selection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4514317&req=5

f1-ott-8-1753: The flow chart of article selection.
Mentions: The flow chart of article selection was presented in Figure 1. A total of 94 literatures were identified through PubMed, Embase, Chinese National Knowledge Infrastructure, and Wang Fang databases. After reviewing the titles and abstracts of the potential available articles, 76 records were excluded mainly because they were of no relevance, were in vitro experiments or were reviews. From the remaining 18 articles, we eliminated five publications due to their nonrelation with IL-2 -330T/G polymorphism, and three publications due to their insufficient genotype data. Finally, ten articles, including ten studies with 3,060 cases and 3,435 controls, were included in this meta-analysis.

Bottom Line: The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.However, further detailed studies are still required to confirm our findings.

View Article: PubMed Central - PubMed

Affiliation: Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People's Republic of China.

ABSTRACT

Purpose: Some studies have investigated the association of IL-2 -330T/G (rs2069762) polymorphism with cancer risk, but the previous results were conflicting and had relatively low statistical power. Thus, we performed a meta-analysis to derive a more precise estimation of the association between IL-2 -330T/G polymorphism and cancer risk.

Methods: A literature search was performed systematically using electronic databases. The odds ratio (OR) with 95% confidence interval (CI) was used to estimate the pooled effect.

Results: A total of ten studies including 3,060 cases and 3,435 controls were involved in this meta-analysis. The results indicated that IL-2 -330T/G polymorphism was significantly associated with cancer risk ([OR =2.03, 95% CI =1.40-2.95] for GG vs TT; [OR =1.37, 95% CI =1.11-1.69] for GT vs TT; [OR =1.46, 95% CI =1.18-1.81] for [GG + GT] vs TT; [OR =1.66, 95% CI =1.24-2.23] for GG vs [GT + TT]; and [OR =1.35, 95% CI =1.16-1.57] for G vs T). In the subgroup analysis according to cancer type, significant association was found in lymphoma ([OR =1.46, 95% CI =1.11-1.91] for GT vs TT; [OR =1.58, 95% CI =1.22-2.05] for [GG + GT] vs TT; [OR =1.84, 95% CI =1.22-2.77] for GG vs [GT + TT]) and other cancers, but not in gastric cancer. In the subgroup analysis by ethnicity, the significant risk was found among Asians, but not among Europeans.

Conclusion: This meta-analysis suggests that IL-2 -330T/G polymorphism has an increased risk of cancer in Asians. However, further detailed studies are still required to confirm our findings.

No MeSH data available.


Related in: MedlinePlus