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Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients.

Aygün F, Efe D - Patient Prefer Adherence (2015)

Bottom Line: Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P<0.021).The rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Surgery, Konya Medical and Research Center, Başkent University, Konya, Turkey.

ABSTRACT

Objective: The aim of the present study was to investigate the association of neutrophil/lymphocyte ratio (NLR) with coronary artery calcium score (CACS) and obstructive coronary artery disease (CAD) detected by multislice computed tomography (MSCT) angiography in type 2 diabetes mellitus (T2DM) patients.

Methods: Two hundred and ninety-two T2DM patients, who were either asymptomatic or symptomatic (but noncharacteristic) for coronary artery disease (CAD) and underwent MSCT angiography in our clinic between May 2009 and June 2014, were enrolled. All patients were divided into two groups according to their mean NLR values. Patients with NLR ≤2.05 were assigned to Group 1 and patients with NLR >2.05 were assigned to Group 2. The association of NLR with CACS and obstructive CAD, which were detected by MSCT angiography, was investigated in T2DM patients.

Results: According to the Agatston scoring method, the mean CACS was 129.5±209.8 Au in Group 1 and 290.3±399.6 Au in Group 2 (P<0.001). Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P<0.021).

Conclusion: The rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05. In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.

No MeSH data available.


Related in: MedlinePlus

Coronary artery disease according to groups.Abbreviations: CAD, coronary artery disease; obs, obstructive; NLR, neutrophil/lymphocyte ratio; non-obs, non-obstructive; obs, obstructive.
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f3-ppa-9-1023: Coronary artery disease according to groups.Abbreviations: CAD, coronary artery disease; obs, obstructive; NLR, neutrophil/lymphocyte ratio; non-obs, non-obstructive; obs, obstructive.

Mentions: In the males of Group 1, the mean NLR was 1.55±0.3, the mean age was 54.3±8.8 years, and the mean CACS according to the Agatston scoring was 131.7±204.8 Au, whereas the mean value of serum HbA1c was 7.5±1.8, fasting blood glucose was 130.1±55.1 mg/dL, serum triglyceride was 183.2±132.2 mg/dL, serum HDL was 45.1±14.5 mg/dL, and serum LDL was 116.5±35.7 mg/dL. Of the males, 28 (21.5%) were obese, 47 (36.2%) were smokers, 33 (25.4%) had obsCAD, 73 (56.2%) had HT, 68 (52.3%) had hyperlipidemia, 54 (41.5%) were receiving statin, and 85 (65.4%) were receiving antidiabetic agent (Figure 3).


Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients.

Aygün F, Efe D - Patient Prefer Adherence (2015)

Coronary artery disease according to groups.Abbreviations: CAD, coronary artery disease; obs, obstructive; NLR, neutrophil/lymphocyte ratio; non-obs, non-obstructive; obs, obstructive.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4514314&req=5

f3-ppa-9-1023: Coronary artery disease according to groups.Abbreviations: CAD, coronary artery disease; obs, obstructive; NLR, neutrophil/lymphocyte ratio; non-obs, non-obstructive; obs, obstructive.
Mentions: In the males of Group 1, the mean NLR was 1.55±0.3, the mean age was 54.3±8.8 years, and the mean CACS according to the Agatston scoring was 131.7±204.8 Au, whereas the mean value of serum HbA1c was 7.5±1.8, fasting blood glucose was 130.1±55.1 mg/dL, serum triglyceride was 183.2±132.2 mg/dL, serum HDL was 45.1±14.5 mg/dL, and serum LDL was 116.5±35.7 mg/dL. Of the males, 28 (21.5%) were obese, 47 (36.2%) were smokers, 33 (25.4%) had obsCAD, 73 (56.2%) had HT, 68 (52.3%) had hyperlipidemia, 54 (41.5%) were receiving statin, and 85 (65.4%) were receiving antidiabetic agent (Figure 3).

Bottom Line: Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P<0.021).The rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiovascular Surgery, Konya Medical and Research Center, Başkent University, Konya, Turkey.

ABSTRACT

Objective: The aim of the present study was to investigate the association of neutrophil/lymphocyte ratio (NLR) with coronary artery calcium score (CACS) and obstructive coronary artery disease (CAD) detected by multislice computed tomography (MSCT) angiography in type 2 diabetes mellitus (T2DM) patients.

Methods: Two hundred and ninety-two T2DM patients, who were either asymptomatic or symptomatic (but noncharacteristic) for coronary artery disease (CAD) and underwent MSCT angiography in our clinic between May 2009 and June 2014, were enrolled. All patients were divided into two groups according to their mean NLR values. Patients with NLR ≤2.05 were assigned to Group 1 and patients with NLR >2.05 were assigned to Group 2. The association of NLR with CACS and obstructive CAD, which were detected by MSCT angiography, was investigated in T2DM patients.

Results: According to the Agatston scoring method, the mean CACS was 129.5±209.8 Au in Group 1 and 290.3±399.6 Au in Group 2 (P<0.001). Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P<0.021).

Conclusion: The rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05. In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.

No MeSH data available.


Related in: MedlinePlus