Limits...
The key role of the scaffold on the efficiency of dendrimer nanodrugs.

Caminade AM, Fruchon S, Turrin CO, Poupot M, Ouali A, Maraval A, Garzoni M, Maly M, Furer V, Kovalenko V, Majoral JP, Pavan GM, Poupot R - Nat Commun (2015)

Bottom Line: Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs.Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks.This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.

View Article: PubMed Central - PubMed

Affiliation: 1] Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France [2] Université de Toulouse, UPS, INP, LCC, F-31077 Toulouse, France.

ABSTRACT
Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks. On the contrary, it is generally believed that the properties of dendrimers are essentially related to their terminal groups, and that the internal structure plays the minor role of an 'innocent' scaffold. Here we show that such an assertion is misleading, using convergent information from biological data (human monocytes activation) and all-atom molecular dynamics simulations on seven families of dendrimers (13 compounds) that we have synthesized, possessing identical terminal groups, but different internal structures. This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.

No MeSH data available.


Related in: MedlinePlus

Chemical structure of dendrimers 5a,b-G1–8a-G1.The azabisphosphonic salts are in red, the linkers in blue and variable internal structures in black.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4510975&req=5

f2: Chemical structure of dendrimers 5a,b-G1–8a-G1.The azabisphosphonic salts are in red, the linkers in blue and variable internal structures in black.

Mentions: The seven different families of dendrimers (13 compounds) ended by azabisphosphonic groups that we have synthesized and tested are shown in Figs 1 and 2. Owing to the different terminal groups of the dendrimers before their functionalization by the azabis(phosphonic acid) groups, we have used two different linkers and developed different synthetic strategies.


The key role of the scaffold on the efficiency of dendrimer nanodrugs.

Caminade AM, Fruchon S, Turrin CO, Poupot M, Ouali A, Maraval A, Garzoni M, Maly M, Furer V, Kovalenko V, Majoral JP, Pavan GM, Poupot R - Nat Commun (2015)

Chemical structure of dendrimers 5a,b-G1–8a-G1.The azabisphosphonic salts are in red, the linkers in blue and variable internal structures in black.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4510975&req=5

f2: Chemical structure of dendrimers 5a,b-G1–8a-G1.The azabisphosphonic salts are in red, the linkers in blue and variable internal structures in black.
Mentions: The seven different families of dendrimers (13 compounds) ended by azabisphosphonic groups that we have synthesized and tested are shown in Figs 1 and 2. Owing to the different terminal groups of the dendrimers before their functionalization by the azabis(phosphonic acid) groups, we have used two different linkers and developed different synthetic strategies.

Bottom Line: Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs.Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks.This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.

View Article: PubMed Central - PubMed

Affiliation: 1] Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France [2] Université de Toulouse, UPS, INP, LCC, F-31077 Toulouse, France.

ABSTRACT
Dendrimers are well-defined macromolecules whose highly branched structure is reminiscent of many natural structures, such as trees, dendritic cells, neurons or the networks of kidneys and lungs. Nature has privileged such branched structures for increasing the efficiency of exchanges with the external medium; thus, the whole structure is of pivotal importance for these natural networks. On the contrary, it is generally believed that the properties of dendrimers are essentially related to their terminal groups, and that the internal structure plays the minor role of an 'innocent' scaffold. Here we show that such an assertion is misleading, using convergent information from biological data (human monocytes activation) and all-atom molecular dynamics simulations on seven families of dendrimers (13 compounds) that we have synthesized, possessing identical terminal groups, but different internal structures. This work demonstrates that the scaffold of nanodrugs strongly influences their properties, somewhat reminiscent of the backbone of proteins.

No MeSH data available.


Related in: MedlinePlus