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Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography.

Abazid RM, Kattea MO, Sayed S, Saqqah H, Qintar M, Smettei OA - Avicenna J Med (2015 Jul-Sep)

Bottom Line: Student's t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively.Excessive VAT is significantly associated with positive CAC.VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Prince Sultan Cardiac Center-Al Qassim, Buraydah, Saudi Arabia ; Department of Cardiac Imaging, Prince Sultan Cardiac Center-Al Qassim, Buraydah, Saudi Arabia.

ABSTRACT

Purpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography.

Methods: This study is a single center, cross-sectional study. Eligible patients (n = 159), who under the age of 61 years, with chest pain and mild to moderate probability to have coronary artery disease (CAD) were enrolled. Coronary calcium score and epicardial adipose tissue (EAT) were measured at the level of the left main coronary artery while VAT was measured at the level of the iliac crest.

Results: The average age was (48 ± 8 years). The mean VAT was (38 ± 21 cm(2)) with no significant difference between men and women (38 ± 22 vs. 37 ± 19 P = 0.8) respectively. Student's t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively. Univariate regression analysis showed that VAT and EAT, are strong predictor for CAC (hazard ratio [HR] 1.034, 95% confidence interval [CI: 1.016-1.052]. P <0.001 and [HR] 1.344, 95% CI: [1.129-1.601] P = 0.001), respectively.

Conclusion: Excessive VAT is significantly associated with positive CAC. VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.

No MeSH data available.


Related in: MedlinePlus

Visceral adipose tissues and epicardial adipose tissues are significantly higher in men with coronary calcification than men without calcification. No difference is seen in women regardless of the coronary calcification status
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Figure 3: Visceral adipose tissues and epicardial adipose tissues are significantly higher in men with coronary calcification than men without calcification. No difference is seen in women regardless of the coronary calcification status

Mentions: Student's t-test analysis of subset groups showed that VAT is significantly higher in patients with CAC than in patients without CAC (50 ± 23 vs. 32 ± 18, P < 0.0001) for men but not significant in women (44 ± 26 vs. 35 ± 17 P = 0.1), respectively, [Table 3, Figure 2A and B].


Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography.

Abazid RM, Kattea MO, Sayed S, Saqqah H, Qintar M, Smettei OA - Avicenna J Med (2015 Jul-Sep)

Visceral adipose tissues and epicardial adipose tissues are significantly higher in men with coronary calcification than men without calcification. No difference is seen in women regardless of the coronary calcification status
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4510826&req=5

Figure 3: Visceral adipose tissues and epicardial adipose tissues are significantly higher in men with coronary calcification than men without calcification. No difference is seen in women regardless of the coronary calcification status
Mentions: Student's t-test analysis of subset groups showed that VAT is significantly higher in patients with CAC than in patients without CAC (50 ± 23 vs. 32 ± 18, P < 0.0001) for men but not significant in women (44 ± 26 vs. 35 ± 17 P = 0.1), respectively, [Table 3, Figure 2A and B].

Bottom Line: Student's t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively.Excessive VAT is significantly associated with positive CAC.VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Prince Sultan Cardiac Center-Al Qassim, Buraydah, Saudi Arabia ; Department of Cardiac Imaging, Prince Sultan Cardiac Center-Al Qassim, Buraydah, Saudi Arabia.

ABSTRACT

Purpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography.

Methods: This study is a single center, cross-sectional study. Eligible patients (n = 159), who under the age of 61 years, with chest pain and mild to moderate probability to have coronary artery disease (CAD) were enrolled. Coronary calcium score and epicardial adipose tissue (EAT) were measured at the level of the left main coronary artery while VAT was measured at the level of the iliac crest.

Results: The average age was (48 ± 8 years). The mean VAT was (38 ± 21 cm(2)) with no significant difference between men and women (38 ± 22 vs. 37 ± 19 P = 0.8) respectively. Student's t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively. Univariate regression analysis showed that VAT and EAT, are strong predictor for CAC (hazard ratio [HR] 1.034, 95% confidence interval [CI: 1.016-1.052]. P <0.001 and [HR] 1.344, 95% CI: [1.129-1.601] P = 0.001), respectively.

Conclusion: Excessive VAT is significantly associated with positive CAC. VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.

No MeSH data available.


Related in: MedlinePlus